Zobrazeno 1 - 10
of 12
pro vyhledávání: '"M. R. Dobrinska"'
Publikováno v:
Journal of Chromatography. 308:251-259
The pivaloyloxyethyl ester of methyldopa is an antihypertensive prodrug possessing improved bioavailability properties over methyldopa. A sensitive cation-exchange, high-performance liquid chromatographic assay using electrochemical detection has bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c28695716353a4c5cf234467db8a7da
https://doi.org/10.1016/s0021-9673(01)87551-8
https://doi.org/10.1016/s0021-9673(01)87551-8
Publikováno v:
Biopharmaceutics & Drug Disposition. 12:571-576
The influence of concomitant food intake on plasma concentrations of the antidepressant drug fluvoxamine maleate was investigated in a two-way, crossover study design. Eight male and four female healthy, young volunteers received a single oral dose o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::064fbffc86650f47f6bc73f8948d465a
https://doi.org/10.1002/bdd.2510120803
https://doi.org/10.1002/bdd.2510120803
Publikováno v:
Rapid communications in mass spectrometry : RCM. 10(9)
MK-0462 (rizatriptan) is a 5HT1D agonist being developed for the treatment of migraine. The assay for this substance in plasma and urine is based on HPLC with tandem mass spectrometry (MS/MS) detection. The procedure has been modified to include the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::07e5b8c555f3bd37731b38b7ca464576
https://pubmed.ncbi.nlm.nih.gov/8755236
https://pubmed.ncbi.nlm.nih.gov/8755236
Autor:
H, Cheng, J D, Rogers, A E, Sweany, M R, Dobrinska, E A, Stein, A C, Tate, R D, Amin, H, Quan
Publikováno v:
Pharmaceutical research. 9(12)
The effects of age and of gender on the plasma profiles of HMG-CoA reductase inhibitors following separate once-a-day dosage regimens (17 days) of lovastatin (80 mg/day) and simvastatin (40 mg/day) were studied in hypercholesterolemic patients. In ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d63faf831c5510dc9bca92d99bf92867
https://pubmed.ncbi.nlm.nih.gov/1488408
https://pubmed.ncbi.nlm.nih.gov/1488408
Autor:
Walfred S. Saari, D. W. Cochran, M. R. Dobrinska, S. L. Gaul, D. C. Titus, Wasyl Halczenko, C. S. Sweet, W. C. Vincek
Publikováno v:
Journal of Medicinal Chemistry. 27:713-717
The (5-methyl-2-oxo-1,3- dioxol -4-yl)methyl and (5-tert-butyl-2-oxo-1, 3- dioxol -4-yl)methyl esters of 3-hydroxy-alpha-methyltyrosine (methyldopa) were prepared and evaluated as progenitors of the amino acid. 1H NMR experiments reveal that the este
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85a2d546b707677ef9c86a8496e2f8d0
https://doi.org/10.1021/jm00372a002
https://doi.org/10.1021/jm00372a002
Autor:
M. R. Dobrinska, J. Demetriades, Eckhard Beubler, W. R. Kukovetz, J. A. Bolognese, H. Lorraine Leidy, H. J. Gomez
Publikováno v:
Journal of Pharmacokinetics and Biopharmaceutics. 10:587-600
A prodrug of methyldopa, the pivaloyloxyethyl (POE) ester, was administered orally to healthy human volunteers at doses equivalent to 500 and 1000 mg of methyldopa and was compared to oral and intravenous doses of methyldopa. The time courses of avai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d5ecec0c57d1191a5cca72916d34ab7
https://doi.org/10.1007/bf01062542
https://doi.org/10.1007/bf01062542
Publikováno v:
Clinical Pharmacology and Therapeutics. 42:82-88
In normal humans sulindac, a prodrug, undergoes two major biotransformations: irreversible oxidation to the inactive sulfone metabolite and reversible reduction to the pharmacologically active sulfide metabolite. To assess any effect of end-stage ren
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f31ba2a4df0c701d826f9f39e8783ee6
https://doi.org/10.1038/clpt.1987.112
https://doi.org/10.1038/clpt.1987.112
Publikováno v:
Clinical pharmacology and therapeutics. 33(2)
Four subjects were studied by continuous intraduodenal sampling to establish the existence and determine the extent of enterohepatic recirculation of sulindac and its sulfide and sulfone metabolites. Sulindac, 200 mg by mouth, was given every 12 hr f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6ec78e9028dac60d4fa640f26cdf4b1
https://pubmed.ncbi.nlm.nih.gov/6822030
https://pubmed.ncbi.nlm.nih.gov/6822030
Publikováno v:
Clinical pharmacology and therapeutics. 22(5 Pt 1)
An example from the literature has been used to demonstrate errors involved in calculating drug clearance by inappropriate use of the apparent drug distribution volume Vdext. The Vdext is always an overestimate of the true volume of distribution in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::21e874f57b78463eb1cc04dc5d78edef
https://pubmed.ncbi.nlm.nih.gov/913028
https://pubmed.ncbi.nlm.nih.gov/913028
Autor:
M. R. Dobrinska
Publikováno v:
Journal of clinical pharmacology. 29(7)
Review on the processes of biliary excretion and enterohepatic circulation of drugs and the pharmacokinetic and pharmacodynamic consequences thereof
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09956c9ee91b77cc8cf470cd5d612679
https://pubmed.ncbi.nlm.nih.gov/2760253
https://pubmed.ncbi.nlm.nih.gov/2760253