Zobrazeno 1 - 10
of 287
pro vyhledávání: '"M. Pokharel"'
Autor:
Jeevan B. Gc, Justin Chen, Swechha M. Pokharel, Indira Mohanty, Charles Mariasoosai, Peter Obi, Paul Panipinto, Smarajit Bandyopadhyay, Santanu Bose, Senthil Natesan
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract A growing body of evidence suggests that oxysterols such as 25-hydroxycholesterol (25HC) are biologically active and involved in many physiological and pathological processes. Our previous study demonstrated that 25HC induces an innate immun
Externí odkaz:
https://doaj.org/article/30b27e54f69140f39a4a1fadff107675
Autor:
Swechha M. Pokharel, Indira Mohanty, Charles Mariasoosai, Tanya A. Miura, Lisette A. Maddison, Senthil Natesan, Santanu Bose
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
Respiratory Syncytial Virus (RSV) is a non-segmented negative-sense RNA virus belonging to the paramyxovirus family. RSV infects the respiratory tract to cause pneumonia and bronchiolitis in infants, elderly, and immunocompromised patients. Effective
Externí odkaz:
https://doaj.org/article/01cfc0a057b64bceae85084bb13be137
Autor:
Kim Chiok, Swechha M. Pokharel, Indira Mohanty, Lindsay Grace Miller, Shou-Jiang Gao, Arthur L. Haas, Kim C. Tran, Michael N. Teng, Santanu Bose
Publikováno v:
mBio, Vol 13, Iss 1 (2022)
ABSTRACT Paramyxoviruses such as respiratory syncytial virus (RSV) are the leading cause of pneumonia in infants, the elderly, and immunocompromised individuals. Understanding host-virus interactions is essential for the development of effective inte
Externí odkaz:
https://doaj.org/article/704d278d042044dc80a349c065feb783
Autor:
Swechha M. Pokharel, Niraj K. Shil, Jeevan B. GC, Zachary T. Colburn, Su-Yu Tsai, Jesus A. Segovia, Te-Hung Chang, Smarajit Bandyopadhyay, Senthil Natesan, Jonathan C. R. Jones, Santanu Bose
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Integrins are key modulators of cell adhesion and signaling. Here the authors show, unexpectedly, that a complex of integrins and the lipid 25-hydroxycholesterol induces FAK activation and proinflammatory cytokine production, thereby serving as an in
Externí odkaz:
https://doaj.org/article/39041573d0274347a3d21da9222a9805
Publikováno v:
PLoS ONE, Vol 16, Iss 9, p e0257576 (2021)
Exaggerated inflammatory response results in pathogenesis of various inflammatory diseases. Tumor Necrosis Factor-alpha (TNF) is a multi-functional pro-inflammatory cytokine regulating a wide spectrum of physiological, biological, and cellular proces
Externí odkaz:
https://doaj.org/article/665937c4076d4c1cbea27137c547987b
Autor:
Nicholas M Negretti, Yinyin Ye, Lais M Malavasi, Swechha M Pokharel, Steven Huynh, Susan Noh, Cassidy L Klima, Christopher R Gourley, Claude A Ragle, Santanu Bose, Torey Looft, Craig T Parker, Geremy Clair, Joshua N Adkins, Michael E Konkel
Publikováno v:
Gut Microbes, Vol 12, Iss 1 (2020)
The symptoms of infectious diarrheal disease are mediated by a combination of a pathogen’s virulence factors and the host immune system. Campylobacter jejuni is the leading bacterial cause of diarrhea worldwide due to its near-ubiquitous zoonotic a
Externí odkaz:
https://doaj.org/article/514f03e05aba4a3b83309a0d4398f590
Autor:
Basanta M. Pokharel, Namrata Chaudhary
Publikováno v:
Rupandehi Campus Journal. 3:40-48
Thyroid gland is vital gland. It produces Thyroxine T3 and Tri-Idothyronine T4 hormones which are needed for the growth and development. Iodine is needed for the formation of T3 and T4 hormones. Iodine is found in different food such as sea food, veg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a236c7c4ce0aa9d076b1cee0f968f97
https://doi.org/10.3126/rcj.v3i1.51546
https://doi.org/10.3126/rcj.v3i1.51546
Publikováno v:
Kathmandu University Medical Journal. 20:359-365
Background There are different methods to repair the perforation of the tympanic membrane. Recently cartilage has been used for the repair and results are comparable to temporalis fascia. For surgical procedure endoscope had added good assistance in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0c84d807f68ae7a00949fb708e9afd0
https://doi.org/10.3126/kumj.v20i3.53958
https://doi.org/10.3126/kumj.v20i3.53958
Akademický článek
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Autor:
M, Pokharel, B L, Shrestha, A, Dhakal, P, Rajbhandari, K S, Shrestha, A K, Kc, A, Bhattarai, D R, Karki
Publikováno v:
Kathmandu University medical journal (KUMJ). 19(75)
Background Obstructive sleep apnea is a highly prevalent yet largely under-diagnosed disease that poses a significant burden on the healthcare system. Objective To determine the role of predictors for Obstructive sleep apnea syndrome and its severity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5cf2bb1b8322c182828381c4e5887cdc
https://pubmed.ncbi.nlm.nih.gov/36254425
https://pubmed.ncbi.nlm.nih.gov/36254425