Zobrazeno 1 - 10
of 219
pro vyhledávání: '"M. Plempel"'
Autor:
M. Plempel
Publikováno v:
Mycoses. 23:16-27
Zusammenfassung: Nach den Erfahrungen mit den heute im Handel erhaltlichen Imidazol-Antimykotika kann keines dieser Praparate die bestehenden Therapielucken bei Mykosen innerer Organe befriedigend ausfullen, obwohl sie in der lokalen Mykosetherapie b
Autor:
W. Nusch, M. Plempel
Publikováno v:
Mycoses. 26:600-604
Zusammenfassung: Die systemisch anwendbaren Azol-Antimykotika Ketoconazol und Bay N 7133 sind nach oraler Applikation von 2 × 200 bzw. 1 × 400 mg/die im Cervical- und Vaginalsekret von Patientinnen mit genitalen Sprospilzinfektionen mikrobiologisch
Publikováno v:
Antimicrobial Agents and Chemotherapy. 34:1132-1138
A new triazole, Bay R 3783, was compared with ketoconazole, itraconazole, and fluconazole, which were given via the alimentary tract at three dosages, and amphotericin B, which was given at 1 mg/kg intraperitoneally, in murine models of the systemic
Autor:
M, Plempel
Publikováno v:
Mycoses. 41
The biography of Dr. Manfred Plempel (1930-1994), Chief Mycologist of the Bayer AG, who developed the first antifungal azole, clotrimazole, for clinical applicability is presented.
Autor:
K D, Bremm, M, Plempel
Publikováno v:
Mycoses. 34(1-2)
The influence of bifonazole and other azoles on the leukotriene-metabolism of human neutrophil granulocytes (PMN) was investigated. The cells were stimulated with the Ca-ionophore A23187 over 15 minutes in the presence of the azoles. Subsequently the
Autor:
M. Plempel, E. Wiederholt
Publikováno v:
Thermochimica Acta. 77:375-382
The design and construction of a simple DTA apparatus for teaching purposes with an electric soldering pot as oven are described. The efficiency of the apparatus is demonstrated by the dehydration of BaCl 2 · 2 H 2 O. Upon rapid heating of the oven
Autor:
M. Plempel, D. Berg
Publikováno v:
Dermatology. 169:3-9
Bifonazole, a new broad-spectrum antimycotic, interferes with sterol biosynthesis. Compared to clotrimazole, the primary mode of action of these two antimycotics is accepted to represent inhibition of the cytochrome P450-dependent hydroxylation at th
Autor:
W Ritter, M. Plempel
Publikováno v:
Journal of Antimicrobial Chemotherapy. 14:243-252
Methods of assay of the oral triazole antimycotic vibunazole (BAY n 7133) in body fluids by GLC, HPTLC and by a microbiological assay are described and compared. Bioassay data of vibunazole concentrations in mice and rats are lower than those of the
Autor:
I. Haller, M. Plempel
Publikováno v:
Current Medical Research and Opinion. 5:315-327
SummaryStudies Were Carried Out With The Current Leading Antimycotic Agents, Using Identical Test Methods, To Compare Their Activity In Vitro And In Animal In Vivo Experiments. In The Broth Dilution Test, The Minimum Inhibitory Concentrations Against
Autor:
M. Plempel
Publikováno v:
Postgraduate Medical Journal. 55:662-666
Summary According to data on the imidazole antimycotics at present on the market, none of these products satisfactorily fills the gaps which exist in the treatment for mycoses of internal organs, although they have brought considerable progress in th