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of 10
pro vyhledávání: '"M. Pilar Sepulcre"'
Autor:
Iván Mulero, José Meseguer, Alfonsa García-Ayala, Victoriano Mulero, M. Pilar Sepulcre, Francisco J. Roca
Publikováno v:
Developmental & Comparative Immunology. 32:1151-1159
Summary Two major professional phagocyte populations have been described in fish, namely granulocytes and monocytes/macrophages. Although the distribution and localization of macrophages have been documented in several teleost species using mainly li
Autor:
Pablo Pelegrín, José Meseguer, M. Pilar Sepulcre, Iván Mulero, Victoriano Mulero, Gloria Lopez-Castejon
Publikováno v:
Molecular Immunology. 45:49-57
Caspases are a family of cysteine proteases that fulfil critical roles in mammalian apoptosis and in the proteolytic activation of cytokines. In humans, the caspase family includes 13 members whose functions seem to correlate with their phylogenetic
Publikováno v:
Proceedings of the National Academy of Sciences. 104:19434-19439
Mast cells are important as initiators and effectors of innate immunity and regulate the adaptive immune responses. They have been described in all classes of vertebrates and seem to be morphologically and functionally similar. However, early studies
Autor:
Barbara Castellana, Josep V. Planas, Francisco J. Roca, José Meseguer, Gloria Lopez-Castejon, M. Pilar Sepulcre, Victoriano Mulero
Publikováno v:
Molecular Immunology. 44:2772-2780
Interleukin-1beta (IL-1beta) is the prototypic pro-inflammatory cytokine. All the biological effects of IL-1beta are mediated through interaction with type 1 IL-1 receptor (IL-1RI), whereas another receptor, called type 2 IL-1R (IL-1RII), lacks an in
Publikováno v:
Molecular Immunology. 44:2009-2016
Phagocytic cells form the cellular arm of the innate immune system. A primary role of these cells is an ability to discriminate large number of potential pathogens from self, using a restricted number of receptors. In the gilthead seabream, acidophil
Autor:
Frederick W. Goetz, Barbara Castellana, Dimitar B. Iliev, Victoriano Mulero, M. Pilar Sepulcre, Simon MacKenzie, Josep V. Planas
Publikováno v:
Molecular immunology. 45(12)
A cDNA clone, designated sbIL-6 (seabream interleukin-6), was obtained from a cDNA library of enriched immune-stimulated sequences from gilthead seabream. The deduced sbIL-6 protein corresponds to a 225-amino acid protein with a putative 24-amino aci
Autor:
Inmaculada Fuentes, M. Pilar Sepulcre, Alicia García-Alcázar, José Meseguer, Iván Mulero, Alfonsa García-Ayala, Victoriano Mulero
Publikováno v:
Molecular immunology. 45(10)
Fish eggs are released and embryos hatch into a pathogenically hostile environment, at a time when their immunological capacity is severely limited. Although the eggs are initially protected by the envelope as well as by several innate and adaptive i
Publikováno v:
Molecular immunology. 44(15)
The mechanisms of the cellular immune response involved in the protection of fish against infection by the pathogenic bacterium Vibrio anguillarum are largely unknown. In the present study, sea bass specimens were injected with live or formalin-kille
Autor:
Gloria Lopez-Castejon, Francisco J. Roca, M Pilar Sepulcre, José Meseguer, Victoriano Mulero
Publikováno v:
The Journal of Immunology. 178:S176-S176
IL-1β is a potent pro-inflammatory cytokine which is translated as a leaderless 33 kDa precursor protein (proIL-1β) that is processed into its 17 kDa active form by the IL-1β-converting enzyme (ICE, caspase-1). Several stimuli have been reported t
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