Validation of human telomere length multi-ancestry meta-analysis association signals identifies POP5 and KBTBD6 as human telomere length regulation genes

Autor: Rebecca Keener, Surya B. Chhetri, Carla J. Connelly, Margaret A. Taub, Matthew P. Conomos, Joshua Weinstock, Bohan Ni, Benjamin Strober, Stella Aslibekyan, Paul L. Auer, Lucas Barwick, Lewis C. Becker, John Blangero, Eugene R. Bleecker, Jennifer A. Brody, Brian E. Cade, Juan C. Celedon, Yi-Cheng Chang, L. Adrienne Cupples, Brian Custer, Barry I. Freedman, Mark T. Gladwin, Susan R. Heckbert, Lifang Hou, Marguerite R. Irvin, Carmen R. Isasi, Jill M. Johnsen, Eimear E. Kenny, Charles Kooperberg, Ryan L. Minster, Take Naseri, Satupa’itea Viali, Sergei Nekhai, Nathan Pankratz, Patricia A. Peyser, Kent D. Taylor, Marilyn J. Telen, Baojun Wu, Lisa R. Yanek, Ivana V. Yang, Christine Albert, Donna K. Arnett, Allison E. Ashley-Koch, Kathleen C. Barnes, Joshua C. Bis, Thomas W. Blackwell, Eric Boerwinkle, Esteban G. Burchard, April P. Carson, Zhanghua Chen, Yii-Der Ida Chen, Dawood Darbar, Mariza de Andrade, Patrick T. Ellinor, Myriam Fornage, Bruce D. Gelb, Frank D. Gilliland, Jiang He, Talat Islam, Stefan Kaab, Sharon L. R. Kardia, Shannon Kelly, Barbara A. Konkle, Rajesh Kumar, Ruth J. F. Loos, Fernando D. Martinez, Stephen T. McGarvey, Deborah A. Meyers, Braxton D. Mitchell, Courtney G. Montgomery, Kari E. North, Nicholette D. Palmer, Juan M. Peralta, Benjamin A. Raby, Susan Redline, Stephen S. Rich, Dan Roden, Jerome I. Rotter, Ingo Ruczinski, David Schwartz, Frank Sciurba, M. Benjamin Shoemaker, Edwin K. Silverman, Moritz F. Sinner, Nicholas L. Smith, Albert V. Smith, Hemant K. Tiwari, Ramachandran S. Vasan, Scott T. Weiss, L. Keoki Williams, Yingze Zhang, Elad Ziv, Laura M. Raffield, Alexander P. Reiner, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, TOPMed Hematology and Hemostasis Working Group, TOPMed Structural Variation Working Group, Marios Arvanitis, Carol W. Greider, Rasika A. Mathias, Alexis Battle

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)

Abstract Genome-wide association studies (GWAS) have become well-powered to detect loci associated with telomere length. However, no prior work has validated genes nominated by GWAS to examine their role in telomere length regulation. We conducted a

Externí odkaz: https://doaj.org/article/3e293e6c932a4a42b553d789d690044b

Accidental Infection of Laboratory Worker with Vaccinia

Autor: Nissin Moussatché, Mari Tuyama, Sayuri E.M. Kato, Ana Paula V. Castro, Brian Njaine, Regina H. Peralta, M. Peralta, Clarissa R.A. Damaso, Paulo F. Barroso

Publikováno v: Emerging Infectious Diseases, Vol 9, Iss 6, Pp 724-726 (2003)

We report the accidental needlestick inoculation of a laboratory worker with vaccinia virus. Although the patient had previously been vaccinated against smallpox, severe lesions appeared on the fingers. Western blot and polymerase chain reaction–re

Externí odkaz: https://doaj.org/article/dfef8d02ea944fe38dd49dd0ba07e68e

Future trends of additive manufacturing in medical applications: An overview

Autor: Jorge L. Amaya-Rivas, Bryan S. Perero, Carlos G. Helguero, Jorge L. Hurel, Juan M. Peralta, Francisca A. Flores, José D. Alvarado

Publikováno v: Heliyon, Vol 10, Iss 5, Pp e26641- (2024)

Additive Manufacturing (AM) has recently demonstrated significant medical progress. Due to advancements in materials and methodologies, various processes have been developed to cater to the medical sector's requirements, including bioprinting and 4D,

Externí odkaz: https://doaj.org/article/a12ef50cb9794cfd9a63ed67ef30219b

A rapid approach for sex assignment by RAD-seq using a reference genome.

Autor: Diego M Peralta, Juan I Túnez, Ulises E Rodríguez Cruz, Santiago G Ceballos

Publikováno v: PLoS ONE, Vol 19, Iss 4, p e0297987 (2024)

Sex identification is a common objective in molecular ecology. While many vertebrates display sexual dimorphism, determining the sex can be challenging in certain situations, such as species lacking clear sex-related phenotypic characteristics or in

Externí odkaz: https://doaj.org/article/474c54bc041d4f33b7d571d62055e290

An electrocoagulation (EC) process with a novel edge insulated electrode for separation of oil-in-water emulsions

Autor: Jun-Ying Wang, Abudukeremu Kadier, Juan M. Peralta-Hernández, Cun-Guang Liang, Peng-Cheng Ma

Publikováno v: Case Studies in Chemical and Environmental Engineering, Vol 7, Iss , Pp 100354- (2023)

The high oil removal efficiency, easy to automate and environmental adaptability make electrocoagulation (EC) technology well-suited for separation of oil-water mixtures. However, achieving high removal efficiency while to reduce the economic costs i

Externí odkaz: https://doaj.org/article/70514997aa5544d9b90a6a8a069ac4b6