Výsledky vyhledávání - "M. P. Stephan"

Akademický článek

Liquid foam improves potency and safety of gene therapy vectors

Autor: K. Fitzgerald, S. B. Stephan, N. Ma, Q. V. Wu, M. T. Stephan

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)

Abstract Interest in gene therapy medicines is intensifying as the first wave of gene-correcting drugs is now reaching patient populations. However, efficacy and safety concerns, laborious manufacturing protocols, and the high cost of the therapeutic

Externí odkaz: https://doaj.org/article/1c8ba852bfce4937bb9eebda8b7353b5

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Akademický článek

In vitro-transcribed antigen receptor mRNA nanocarriers for transient expression in circulating T cells in vivo

Autor: N. N. Parayath, S. B. Stephan, A. L. Koehne, P. S. Nelson, M. T. Stephan

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)

Ex vivo engineering of antigen-specific T cells has shown therapeutic efficacy but can be costly and scarce. Here the authors show that in vitro-transcribed antigen receptor mRNA packaged in nanocarriers can directly induce, in vivo, transient their

Externí odkaz: https://doaj.org/article/0d662657f13f42b8babe9affe4eb6b2f

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Akademický článek

Genetic programming of macrophages to perform anti-tumor functions using targeted mRNA nanocarriers

Autor: F. Zhang, N. N. Parayath, C. I. Ene, S. B. Stephan, A. L. Koehne, M. E. Coon, E. C. Holland, M. T. Stephan

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)

The previous efforts to reprogramme tumour-associated macrophages (TAMs) to M1 phenotype have caused undesired side-effects. Here, the authors report targeted nanocarriers for delivering mRNA encoding M1-polarizing transcription factors to TAMs and s

Externí odkaz: https://doaj.org/article/138b3dd54491408c818b9a2f0d6eaf97

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Akademický článek

Hit-and-run programming of therapeutic cytoreagents using mRNA nanocarriers

Autor: H. F. Moffett, M. E. Coon, S. Radtke, S. B. Stephan, L. McKnight, A. Lambert, B. L. Stoddard, H. P. Kiem, M. T. Stephan

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)

Current widely used viral and electroporation methods for creating therapeutic cell-based products are complex and expensive. Here, the authors develop targeted mRNA nanocarriers that can transiently program gene expression by simply mixing them with

Externí odkaz: https://doaj.org/article/980299c002f4470893064c45e6cc2b18

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Electrophoresis SDS-PAGE and Tricine-SDS-PAGE to differentiate black and yellow soybean: a molecular approach

Autor: M. P. Stephan, M. C. Carrão-Panizzi, I. Felberg

Publikováno v: South Florida Journal of Development. 2:2592-2599

Soybean is well recognized for having several bioactive compounds. Black soybeans have been used in Eastern countries as a healthy food and as an medicinal alternative. The identification of natural substances, such as peptides, present in black and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68540f2f5b933ad6a34445ea39753f7f
https://doi.org/10.46932/sfjdv2n2-114

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Artisan minas cheese of Serro: proteolysis during ripening

Autor: Cleube Andrade Boari, Juliana de Oliveira Carneiro, Maria Gabriela Bello Koblitz, M. P. Stephan, Ana Carolina Sampaio Doria Chaves

Publikováno v: Heliyon
Heliyon, Vol 6, Iss 7, Pp e04446-(2020)

The Artisan Minas Cheese (AMC) is the oldest and most traditional Brazilian cheese, it is produced in several regions of the state of Minas Gerais, such as the Serro region. The most striking features of the AMC-Serro are the use of raw milk and natu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b378d9c07528eafb67c9b98515245f73
https://pubmed.ncbi.nlm.nih.gov/32695917

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Akademický článek

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Optimization of the Electrophoresis Tricine-SDS-PAGE for Simultaneous Detection of Protein and Peptide in Artisinal Cheese

Autor: Maria Gabriela Bello Koblitz, Izabela Miranda de Castro, Juliana de Oliveira Carneiro, Ana Carolina Sampaio Doria Chaves, Alexsandro Araujo dos Santos, Tatiana Azevedo, M. P. Stephan

Publikováno v: Journal of Agricultural Science and Technology B. 9

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e0950b32c2d0fde71ff618dd841647c6
https://doi.org/10.17265/2161-6264/2019.06.006

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Evaluation of the antioxidant potential of whey protein concentrated by ultrafiltration and hydrolyzed by different commercial proteases

Autor: Renata V. Tonon, M. P. Stephan, Renata Silva Cabral de Souza, Caroline Mellinger Silva, A. L. Penteado, Louise Emy Kurozawa, Lourdes Maria Corrêa Cabral

Publikováno v: Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA-Alice)
Empresa Brasileira de Pesquisa Agropecuária (Embrapa)
instacron:EMBRAPA
Brazilian Journal of Food Technology, Volume: 22, Article number: e2018021, Published: 11 APR 2019
Brazilian Journal of Food Technology v.22 2019
Brazilian Journal of Food Technology
Instituto de Tecnologia de Alimentos (ITAL)
instacron:ITAL
Brazilian Journal of Food Technology, Vol 22, Iss 0 (2019)

Resumo: O objetivo do trabalho foi avaliar as atividades antioxidante e antimicrobiana de hidrolisados proteicos de soro de leite obtidos por diferentes proteases (Alcalase e Flavourzyme) e sua mistura (proporção 50:50). Previamente à hidrólise e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0cb161f9fd93bf8d60218f24912334f
http://www.alice.cnptia.embrapa.br/alice/handle/doc/1115788

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