Výsledky vyhledávání - "M. P. Ponomarenko"

Akademický článek

Human_SNP_TATAdb: a database of SNPs that statistically significantly change the affinity of the TATA-binding protein to human gene promoters: genome-wide analysis and use cases

Autor: S. V. Filonov, N. L. Podkolodnyy, O. A. Podkolodnaya, N. N. Tverdokhleb, P. M. Ponomarenko, D. A. Rasskazov, A. G. Bogomolov, M. P. Ponomarenko

Publikováno v: Вавиловский журнал генетики и селекции, Vol 27, Iss 7, Pp 728-736 (2023)

It was previously shown that the expression levels of human genes positively correlate with TBP affinity for the promoters of these genes. In turn, single nucleotide polymorphisms (SNPs) in human gene promoters can affect TBP affinity for DNA and, as

Externí odkaz: https://doaj.org/article/14f85392ff824690838423cb1a50b7ce

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Akademický článek

RatDEGdb: a knowledge base of differentially expressed genes in the rat as a model object in biomedical research

Publikováno v: Вавиловский журнал генетики и селекции, Vol 27, Iss 7, Pp 794-806 (2023)

The animal models used in biomedical research cover virtually every human disease. RatDEGdb, a knowledge base of the differentially expressed genes (DEGs) of the rat as a model object in biomedical research is a collection of published data on gene e

Externí odkaz: https://doaj.org/article/0c6cf91b7b744b219c02c841fa9405ae

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Akademický článek

An experimental study of the effects of SNPs in the TATA boxes of the GRIN1, ASCL3 and NOS1 genes on interactions with the TATA-binding protein

Autor: E. B. Sharypova, I. A. Drachkova, I. V. Chadaeva, M. P. Ponomarenko, L. K. Savinkova

Publikováno v: Вавиловский журнал генетики и селекции, Vol 26, Iss 3, Pp 227-233 (2022)

The GRIN1, ASCL3, and NOS1 genes are associated with various phenotypes of neuropsychiatric disorders. For instance, these genes contribute to the development of schizophrenia, Alzheimer’s and Parkinson’s diseases, and epilepsy. These genes are a

Externí odkaz: https://doaj.org/article/a23192b3b2404920b465c541ec6bf998

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Akademický článek

A bioinformatic search for correspondence between differentially expressed genes of domestic versus wild animals and orthologous human genes altering reproductive potential

Autor: M. P. Ponomarenko, I. V. Chadaeva, P. M. Ponomarenko, A. G. Bogomolov, D. Yu. Oshchepkov, E. B. Sharypova, V. V. Suslov, A. V. Osadchuk, L. V. Osadchuk, Yu. G. Matushkin

Publikováno v: Вавиловский журнал генетики и селекции, Vol 26, Iss 1, Pp 96-108 (2022)

One of the greatest achievements of genetics in the 20th century is D.K. Belyaev’s discovery of destabilizing selection during the domestication of animals and that this selection affects only gene expression regulation (not gene structure) and inf

Externí odkaz: https://doaj.org/article/c2e3e6835d7f4a1aba8cdbd538a66141

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Akademický článek

Russian Science Foundation grant No. 20-14-00140 supported this study. The authors are thankful to the multi-access Center 'Bioinformatics' for the use of computational resources as supported by Russian government project FWNR-2022-0020 and the Russian Federal Science and Technology Program for the Development of Genetic Technologies.

Autor: O. V. Vishnevsky, I. V. Chadaeva, E. B. Sharypova, B. M. Khandaev, K. A. Zolotareva, A. V. Kazachek, P. M. Ponomarenko, N. L. Podkolodny, D. A. Rasskazov, E. V. Zemlyanskaya, A. G. Bogomolov, O. A. Podkolodnaya, L. K. Savinkova, M. P. Ponomarenko

Publikováno v: Вавиловский журнал генетики и селекции, Vol 26, Iss 8 (2023)

It is generally accepted that during the domestication of food plants, selection was focused on their productivity, the ease of their technological processing into food, and resistance to pathogens and environmental stressors. Besides, the palatabili

Externí odkaz: https://doaj.org/article/eb1502a16a7b416680caf03becbcfb42

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Akademický článek

Candidate SNP-markers altering TBP binding affinity for promoters of the Y-linked genes CDY2A, SHOX, and ZFY are lowering many indexes of reproductive potential in men

Autor: M. P. Ponomarenko, E. B. Sharypova, I. A. Drachkova, L. K. Savinkova, I. V. Chadaeva, D. A. Rasskazov, P. M. Ponomarenko, L. V. Osadchuk, A. V. Osadchuk

Publikováno v: Вавиловский журнал генетики и селекции, Vol 24, Iss 7, Pp 785-793 (2020)

Reproductive potential is the most important conditional indicator reflecting the ability of individuals in a population to reproduce, survive and develop under optimal environmental conditions. As for humans, the concept of reproductive potential ca

Externí odkaz: https://doaj.org/article/837b58a0d0bd4f98a5e1fd7881fe8950

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Akademický článek

Сandidate SNP-markers of rheumatoid arthritis that can significantly alter the affinity of the TATA-binding protein for human gene promoters

Autor: I. V. Chadaeva, D. A. Rasskazov, E. B. Sharypova, I. A. Drachkova, E. A. Oshchepkova, L. K. Savinkova, P. M. Ponomarenko, M. P. Ponomarenko, N. A. Kolchanov, V. A. Kozlov

Publikováno v: Вавиловский журнал генетики и селекции, Vol 23, Iss 8, Pp 1047-1058 (2020)

Rheumatoid polyarthritis (RA) is an autoimmune disease with autoantibodies, including antibodies to citrullant antigens and proinflammatory cytokines, such as TNF-α and IL-6, which are involved in the induction of chronic synovitis, bone erosion, fo

Externí odkaz: https://doaj.org/article/a4d34014ce894a0184ae1fa2ee6de0e3

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Akademický článek

AN EXPERIMENTAL STUDY OF THE EFFECT OF RARE POLYMORPHISMS OF HUMAN HBB, HBD AND F9 PROMOTER TATA BOXES ON THE KINETICS OF INTERACTION WITH THE TATA-BINDING PROTEIN

Autor: E. B. Sharypova, I. A. Drachkova, E. V. Kashina, D. A. Rasskazov, P. M. Ponomarenko, M. P. Ponomarenko, N. А. Kolchanov, L. K. Savinkova

Publikováno v: Вавиловский журнал генетики и селекции, Vol 22, Iss 1, Pp 145-152 (2018)

Human genes HBB, HBD and F9 belong to the hematopoiesis system. The deficiency or excess of these genes’ products is the cause of hereditary thalassemias of various severity and haemophilia B Leyden. Previously, it was shown that a number of annota

Externí odkaz: https://doaj.org/article/cfa553e1b2a94aae8654a585b48f74ed

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Akademický článek

Candidate SNP markers of social dominance, which may affect the affinity of the TATAbinding protein for human gene promoters

Autor: I. V. Chadaeva, D. A. Rasskazov, E. B. Sharypova, L. K. Savinkova, P. M. Ponomarenko, M. P. Ponomarenko

Publikováno v: Вавиловский журнал генетики и селекции, Vol 20, Iss 6, Pp 787-796 (2017)

The following heuristic hypothesis has been proposed: if an excess of a protein in several animal organs was experimentally identified as physiological marker of increased aggressiveness and if a polymorphism (SNP) can cause superexpression of the hu

Externí odkaz: https://doaj.org/article/dc53a88af6f443448ccf817d0696f7d9

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Akademický článek

Biomedical and candidate SN P markers of chronopathologies can significantly change affinity of ТАТА -binding protein for human gene promoters

Autor: D. A. Rasskazov, N. L. Podkolodnyy, O. A. Podkolodnaya, N. N. Podkolodnaya, V. V. Suslov, L. K. Savinkova, P. M. Ponomarenko, M. P. Ponomarenko

Publikováno v: Вавиловский журнал генетики и селекции, Vol 19, Iss 6, Pp 691-698 (2016)

Computational analysis of millions of unannotated SNPs from the 1000 Genomes Project may speed up the search for biomedical SNP markers. We combined the analysis of SNPs in the binding sites of ТАТА - binding protein (ТВР) using a previously d

Externí odkaz: https://doaj.org/article/1211a0a50e374029b2a5545b7ecd576f

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