Výsledky vyhledávání - "M. P. Hacker"

Akademický článek

Understanding the employment impact of neuromyelitis optica spectrum disorder in the USA: Mixed methods

Autor: Farrah J. Mateen, Cristina M. Trápaga Hacker

Publikováno v: Frontiers in Neurology, Vol 14 (2023)

Neuromyelitis optica spectrum disorder (NMOSD) is a rare and disabling neurological disorder, marked by recurrent attacks of the central nervous system. NMO has a high female predominance and disproportionately affects racial and ethnic groups who ar

Externí odkaz: https://doaj.org/article/be173ea93dfd428ab3c8914bcf3ee612

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Aza and diaza bioisosteric anthracene-9,10-diones as antitumor agents

Autor: F. C. Giuliani, S. Spinelli, M. P. Hacker, Ernesto Menta, Ambrogio Oliva, M. J. Maresch, A. P. Krapcho

Publikováno v: Scopus-Elsevier

Synthetic routes to aza and diaza bioisosteres related to the anthracene-9,10-dione, mitoxantrone, have been developed. The antitumor properties of these chemotypes are compared with those exhibited by the corresponding carbocyclic analogues. The sen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85e519b93a163273aecfe06cab5bcd3b
https://doi.org/10.18388/abp.1995_4896

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ChemInform Abstract: 6,9-Bis((aminoalkyl)amino)benzo(g)isoquinoline-5,10-diones. A Novel Class of Chromophore-Modified Antitumor Anthracene-9,10-diones: Synthesis and Antitumor Evaluations

Autor: J. J. Jun. Landi, Carla Manzotti, Mary E. Petry, F. C. Giuliani, Ambrogio Oliva, M. J. Maresch, J. Stallman, Sergio Tognella, M. P. Hacker, S. Spinelli, Ernesto Menta, Zelleka Getahun, J. F. Polsenberg, A. P. Krapcho, C. E. Gallagher, Gino Beggiolin, G. Pezzoni

Publikováno v: ChemInform. 25

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ccf4768c8a83bd30e04a79b68139640a
https://doi.org/10.1002/chin.199431166

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ChemInform Abstract: The Synthesis of 6,9-Difluorobenzo(g)quinoline-5,10-dione. Displacements of the Fluorides by Diamines Which Lead to 6,9-Bis(( aminoalkyl)amino)benzo(g)quinoline-5,10-diones

Autor: J. J. Jun. Landi, S. Spinelli, M. P. Hacker, J. Stallman, J. F. Polsenberg, Mary E. Petry, A. Oliva, R. Di Domenico, A. P. Krapcho, E. Menta

Publikováno v: ChemInform. 25

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ef02598bca0c075a9c390620c78f8c3c
https://doi.org/10.1002/chin.199424169

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ChemInform Abstract: The Synthesis of 6,9-Bis((aminoalkyl)amino) Substituted Benzo(g) quinoxaline-, Benzo(g)quinazoline- and Benzo(g)phthalazine-5,10-diones via Regiospecific Displacements

Autor: A. L. Helgason, A. P. Krapcho, K. E. Rosner, M. J. Maresch, S. Spinelli, M. P. Hacker, Ambrogio Oliva, Ernesto Menta

Publikováno v: ChemInform. 25

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cd5e436b9ca355e0788edcb07270a71d
https://doi.org/10.1002/chin.199424103

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ChemInform Abstract: Synthesis of 4-Hydroxy-6,9-difluorobenz(g)isoquinoline-5,10-diones and Conversion to 4-Hydroxy-6,9-bis((aminoalkyl)amino)benz(g)isoquinoline- 5,10-diones

Autor: E. Menta, Martin J. Maresch, A. P. Krapcho, S. Spinelli, G. Da Re, A. Oliva, R. Di Domenico, C. E. Gallagher, M. P. Hacker

Publikováno v: ChemInform. 27

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::78807829f56c8667c8844eaf171ec64e
https://doi.org/10.1002/chin.199620130

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ChemInform Abstract: Synthesis of Hydroxy-Substituted Aza-Analogues of Antitumor Anthrapyrazoles

Autor: R. Di Domenico, Abdelhakim Hammach, A. Oliva, G. Da Re, E. Menta, M. P. Hacker, A. Lotto, S. Spinelli, A. P. Krapcho, C. E. Gallagher

Publikováno v: ChemInform. 30

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3d95db58eb59f8d28b9f021becd33ebc
https://doi.org/10.1002/chin.199904149

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Impact of the basic amine on the biological activity and intracellular distribution of an aza-anthrapyrazole: BBR 3422

Autor: K M, Chou, A, Paul Krapcho, M P, Hacker

Publikováno v: Biochemical pharmacology. 62(10)

The anthrapyrazoles have entered clinical trials and show significant activity against breast cancer. However, these drugs are cardiotoxic and ineffective in multidrug-resistant (MDR) tumor cells. We have reported previously on the synthesis and anti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::87b549246e34a1cc1f6630076b5587ba
https://pubmed.ncbi.nlm.nih.gov/11709193

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Mechanisms of asbestos-induced nitric oxide production by rat alveolar macrophages in inhalation and in vitro models

Autor: T R, Quinlan, K A, BeruBe, M P, Hacker, D J, Taatjes, C R, Timblin, J, Goldberg, P, Kimberley, P, O'Shaughnessy, D, Hemenway, J, Torino, L A, Jimenez, B T, Mossman

Publikováno v: Free radical biologymedicine. 24(5)

To evaluate the contribution of reactive nitrogen species to inflammation by asbestos, Fischer 344 rats were exposed to crocidolite or chrysotile asbestos by inhalation to determine whether increases occurred in nitric oxide (NO.) metabolites from al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e888672d9813c18098a6a3211336ed61
https://pubmed.ncbi.nlm.nih.gov/9586808

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Modulation of methotrexate resistance by genistein in murine leukemia L1210 cells

Autor: Y, Xuan, M P, Hacker, T R, Tritton, A, Bhushan

Publikováno v: Oncology reports. 5(2)

We have previously shown that methotrexate (MTX) transport is impaired in murine L1210 cells selected for cisplatin (DDP) resistance (L1210/DDP) and that the decreased MTX uptake may be due to an altered 66 kDa membrane protein. We have further hypot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d47d614061468cfdc741a2f52486e341
https://pubmed.ncbi.nlm.nih.gov/9468571

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