Zobrazeno 1 - 10
of 18
pro vyhledávání: '"M. P. Ducharme"'
Autor:
M-M. Virotte Ducharme
Publikováno v:
Rendiconti di Matematica e delle Sue Applicazioni, Vol 17, Iss 3, Pp 347-371 (1997)
In this paper we construct two groups, the nonsplit extensions 3^7.O_7(3).2 and 3^8.O^−_8 (3).2, as subgroups of the group Fi_{24} and the Bimonster respectively. For these two extensions we exhibite a set of generating involutions and we give pres
Externí odkaz:
https://doaj.org/article/9cb2a27ea75d4c50a71b03f4d58cf984
Publikováno v:
British Journal of Clinical Pharmacology. 40:127-133
1. Stereoselectivity in the disposition of hydroxychloroquine was investigated in 23 healthy males following a single oral dose of 200 mg racemic HCQ (rac-HCQ) sulphate. Total concentrations (R+S) and R/S ratios of HCQ and its metabolites were measur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e0638af03083a6878aa244c29d44ba9
https://doi.org/10.1111/j.1365-2125.1995.tb05768.x
https://doi.org/10.1111/j.1365-2125.1995.tb05768.x
Publikováno v:
Arzneimittel-Forschung. 62(12)
To better understand the pharmacokinetics and potential advantages of a levothyroxine oral solution vs. tablets and soft gel capsules. 4 randomized, 2-treatment, single-dose (600 mcg levothyroxine), 2-way crossover bioequivalence studies in 84 health
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1df4cabe9173d935a9a456c5511e7a6f
https://pubmed.ncbi.nlm.nih.gov/23154888
https://pubmed.ncbi.nlm.nih.gov/23154888
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 37(8)
This study was initiated to characterize the metabolism and pharmacokinetics of SNC80 in rats and to evaluate the impact of Freund's complete adjuvant (FCA)-induced inflammation on its body disposition. In vitro, the disappearance and intrinsic clear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d83d5ca7167bc7538881ea595c8f532e
https://pubmed.ncbi.nlm.nih.gov/17701834
https://pubmed.ncbi.nlm.nih.gov/17701834
Publikováno v:
Journal of veterinary pharmacology and therapeutics. 24(6)
The pharmacokinetics of amoxycillin was studied in nine male beagle dogs under healthy and febrile conditions. In Period 1, dogs received 20 mg/kg of an oral suspension of amoxycillin. Intravenous doses of saline, 2 and 20 microg/kg of endotoxin (LPS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9e120b55496756931749c25d42de3f32
https://pubmed.ncbi.nlm.nih.gov/11903867
https://pubmed.ncbi.nlm.nih.gov/11903867
Autor:
S, Sharma, N, Kemeny, G K, Schwartz, D, Kelsen, E, O'Reilly, D, Ilson, J, Coyle, R L, De Jager, M P, Ducharme, S, Kleban, E, Hollywood, L B, Saltz
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 7(12)
Exatecan mesylate (DX-8951f) is a topoisomerase I inhibitor that has increased solubility and antitumor activity compared with other topoisomerase I inhibitors. The purpose of this study was to establish a safe dose of DX-8951f given as a weekly 24-h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4ea50f09f6238189b232cb745caf4f82
https://pubmed.ncbi.nlm.nih.gov/11751488
https://pubmed.ncbi.nlm.nih.gov/11751488
Autor:
Pamela Dumas, John Coyle, J. Jack Lee, Richard Pazdur, Robert De Jager, Yvonne Lassere, Melanie E. Royce, Paulo M. Hoff, M. P. Ducharme
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 19(5)
PURPOSE: To determine the maximum-tolerated dose (MTD), dose-limiting toxicity (DLT), pharmacokinetic (PK) profile, and recommended phase II dose of Exatecan mesylate (DX-8951f) when administered as a 24-hour continuous infusion every 3 weeks to pati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e41dca9db2e71e24f43124fa18bfc2f
https://pubmed.ncbi.nlm.nih.gov/11230496
https://pubmed.ncbi.nlm.nih.gov/11230496
Autor:
M. P. Ducharme, M. Suzuki, K. Tamanoi, R. De Jager, John Coyle, N. Sakamoto, M. Satomi, P. Cheverton
Publikováno v:
Annals of the New York Academy of Sciences. 922
Exatecan mesylate (DX-8951f) is a new hexacyclic camptothecin analogue with favorable attributes compared to topotecan and CPT-11, including watersolubility, greater potency against topoisomerase I, lack of esterase-dependent activation, broad antitu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::386355267d70da278288eaa5bdce0f15
https://pubmed.ncbi.nlm.nih.gov/11193901
https://pubmed.ncbi.nlm.nih.gov/11193901
Publikováno v:
Pharmaceutical research. 17(6)
To describe the pharmacokinetics of R- and S-Ifosfamide (IFF), and their respective 2 and 3 N-dechloroethylated (DCE) metabolites (R2-, R3-, S2, S3-DCE-IFF) in cancer patients.(R,S)-IFF was administered (1.5 g/m2) daily for 5 days in 13 cancer patien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7b6104dcff22c34a62f774ea4b0de647
https://pubmed.ncbi.nlm.nih.gov/10955835
https://pubmed.ncbi.nlm.nih.gov/10955835
Publikováno v:
Chirality. 11(7)
The objective of this study was to investigate the effect of phenytoin (PHE) on cyclophosphamide (CP) disposition. CP was administered to 6 adult patients in a preparative regimen for bone marrow transplantation consisting of busulfan and CP. Three o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d734e1311f078db02fbda932bf70984c
https://pubmed.ncbi.nlm.nih.gov/10423284
https://pubmed.ncbi.nlm.nih.gov/10423284