Zobrazeno 1 - 10
of 29
pro vyhledávání: '"M. P. A. Young"'
Autor:
Ying Xiong, David M. Neskey, Joshua D. Horton, Chrystal M. Paulos, Hannah M. Knochelmann, Kent E. Armeson, M. Rita I. Young
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-10 (2020)
Abstract Background Although checkpoint blockades have become widely used, the immunological impact in cancer patients, especially those with oral cavity squamous cell carcinoma (OCSCC), has not been well studied. Methods The present study assessed t
Externí odkaz:
https://doaj.org/article/8bbb7d9e97df488fa55d945e594c6643
Autor:
Hannah M. Knochelmann, Joshua D. Horton, Sixue Liu, Kent Armeson, John M. Kaczmar, Megan M. Wyatt, Mary S. Richardson, Shirley H. Lomeli, Ying Xiong, Evan M. Graboyes, Eric J. Lentsch, Joshua D. Hornig, Judith Skoner, Seth Stalcup, Maria V. Spampinato, Elizabeth Garrett-Mayer, Elizabeth C. O’Quinn, Cynthia D. Timmers, Martin J. Romeo, John M. Wrangle, M. Rita I. Young, Mark P. Rubinstein, Terry A. Day, Roger S. Lo, Chrystal M. Paulos, David M. Neskey
Publikováno v:
Cell Reports Medicine, Vol 2, Iss 10, Pp 100426- (2021)
Summary: Oral cavity squamous cell carcinoma (OCSCC) is a prevalent surgically treated subset of head and neck cancer with frequent recurrence and poor survival. Immunotherapy has demonstrated efficacy in recurrent/metastatic head and neck cancer. Ho
Externí odkaz:
https://doaj.org/article/106d0eef51b345229c78936aef78ee40
Publikováno v:
Earth's Future, Vol 7, Iss 10, Pp 1192-1204 (2019)
Event attribution, which determines how anthropogenic climate change has affected the likelihood of certain types of extreme events, is of broad interest to industries, governments, and the public. Attribution results can be highly dependent on the d
Externí odkaz:
https://doaj.org/article/f03e2354caf8417aa6478f61c716a995
Publikováno v:
Frontiers in Psychiatry, Vol 10 (2019)
Post-traumatic stress disorder (PTSD) has been suggested to be associated with an inflammatory immune state, although few studies have examined peripheral blood lymphocytes in subjects that have PTSD and compared immune parameters to subjects that ex
Externí odkaz:
https://doaj.org/article/e9bf039b07f94efa825963bd52aff8b3
Publikováno v:
Mediators of Inflammation, Vol 2019 (2019)
Chronic inflammation is evident in the adipose tissue and periphery of patients with obesity, as well as mouse models of obesity. T cell subsets in obese adipose tissue are skewed towards Th1- and Th17-associated phenotypes and their secreted cytokin
Externí odkaz:
https://doaj.org/article/bb2a56cd0c6944c8bbc589c7997480d8
Publikováno v:
Environmental Research Letters, Vol 16, Iss 9, p 094026 (2021)
Changes in day-to-day (daily) temperature variability have implications for the health of humans and other species and industries such as agriculture. The strongest historical changes in daily temperature variability are decreases in the northern hig
Externí odkaz:
https://doaj.org/article/8a870f49f8c9404088412e175213f2da
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0196034 (2018)
Mice bearing carcinogen-induced premalignant oral lesions were previously shown to have a pro-inflammatory phenotype, which is replaced with an immune inhibitory phenotype as lesions progress to cancer. Since Th17 cells are prominent at the premalign
Externí odkaz:
https://doaj.org/article/f80f4553d6864324a14fee18bb014e1b
Publikováno v:
Frontiers in Psychiatry, Vol 8 (2017)
Patients with posttraumatic stress disorder (PTSD) exhibit an increased state of inflammation. Various animal models for PTSD have shown some of the same immune imbalances as have been shown in human subjects with PTSD, and some of these studies are
Externí odkaz:
https://doaj.org/article/d2655dbd14f641588212c04a0601e44c
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0180724 (2017)
Micro-injuries associated with chronic inhaled particle exposures are linked with activation of the immune response and are thought to contribute to progression of fibrotic disease. In the pulmonary environment, we have previously demonstrated a hete
Externí odkaz:
https://doaj.org/article/ac40271142eb4bb580f3238430f3dce8
Autor:
Sara D. Johnson, M. Rita I. Young
Publikováno v:
Frontiers in Immunology, Vol 7 (2016)
Current treatment options for head and neck squamous cell carcinoma (HNSCC) patients are often ineffective due to tumor localized and systemic immunosuppression. Using the 4-NQO mouse model of oral carcinogenesis, this study showed that premalignant
Externí odkaz:
https://doaj.org/article/ca5a12a9b0464098a2f4dcfa333f917b