Statistical analysis plan for the Surgery for Cancer with Option of Palliative Care Expert (SCOPE) trial: a randomized controlled trial of a specialist palliative care intervention for patients undergoing surgery for cancer

Autor: Onur M. Orun, Myrick C. Shinall, Aimee Hoskins, Ellis Morgan, Mohana Karlekar, Sara F. Martin, E. Wesley Ely, Rameela Raman

Publikováno v: Trials, Vol 22, Iss 1, Pp 1-6 (2021)

Abstract Background The impact of specialist palliative care intervention in patients undergoing surgery for cancer has not been studied extensively. The SCOPE randomized controlled trial will investigate the effect of specialist palliative care inte

Externí odkaz: https://doaj.org/article/6e11047d62fc4f7db5c83c7a43bec2d8

Inflammation and Coagulation during Critical Illness and Long-Term Cognitive Impairment and Disability

Autor: James C. Jackson, Christopher Hughes, Pratik P. Pandharipande, Jennifer L. Thompson, Onur M Orun, J. Brennan McNeil, Timothy D. Girard, Nathan E. Brummel, E. Wesley Ely, Lorraine B. Ware, Gordon R. Bernard, Rameela Raman

Publikováno v: American Journal of Respiratory and Critical Care Medicine. 203:699-706

Rationale: The biological mechanisms of long-term cognitive impairment and disability after critical illness are unclear.Objectives: To test the hypothesis that markers of acute inflammation and coagulation are associated with subsequent long-term co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::64f5e55e83a952155d8caf9467244ad9
https://doi.org/10.1164/rccm.201912-2449oc

Dexmedetomidine or Propofol for Sedation in Mechanically Ventilated Adults with Sepsis

Autor: Patrick T. Mailloux, Joshua T. Swan, Gregg J. Stashenko, Kalpalatha K. Guntupalli, James C. Jackson, Robert S. Dittus, Joanna L. Stollings, Robert D. Sanders, Rameela Raman, Amy L. Kiehl, Onur M Orun, Brenda T. Pun, Gordon R. Bernard, Matthew S. Duprey, Antonio Anzueto, Nathan E. Brummel, Timothy D. Girard, Hollis R. O’Neal, Pratik P. Pandharipande, E. Wesley Ely, Aimee Hoskins, Allison Snyder, Christopher Hughes, Mayur B. Patel, Michael A. Gropper, Lan N. Bui, John W. Devlin

Publikováno v: N Engl J Med

BACKGROUND: Guidelines currently recommend targeting light sedation with dexmedetomidine or propofol for adults receiving mechanical ventilation. Differences exist between these sedatives in arousability, immunity, and inflammation. Whether they affe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9d74b3e068e09471bc6733aaba0f8c4
https://pubmed.ncbi.nlm.nih.gov/33528922

Prevalence and risk factors for delirium in critically ill patients with COVID-19 (COVID-D): a multicentre cohort study

Autor: Ana Vallejo de la Cueva, Pablo T. Aznar, Laura González Cubillo, Chiara Robba, Oriol Plans Galván, Nerea Aretxabala Cortajarena, Robert C. Hyzy, Imen Ben Saida, Jorge Rubio, María José Sánchez Carretero, Katie M. Vance, Blanca Furquet, Irene Patricia Barón Barrera, Sarah J. Peterson, Sara C. LaHue, Sergio Llorente Damas, Andrew R. Vogel, Nihal Patel, Alejandro Suarez-de-la-Rica, Cristina Álvarez, Ricard Molina Latorre, Günseli Orhun, Karen Shephard, Marta Martín Martínez, Paula Castello-Mora, Guillem Navarra-Ventura, Michelle Woodham, Carmen Andrea Sanchis-Veryser, Annachiara Marra, Kristine Nelson, Carolina Ferrer Gómez, Francisco Javier Morán Gallego, Muhammed Elhadi, Sarah Cohen, María Esther Rodriguez Delgado, Rafael Badenes, Isabel Reyes García, Christopher Berkey, Karla Núñez Vázquez, Beata-Gabriela K Simpson, Amaia Quintano Rodero, María Pilar Vicente-Fernández, María Luisa García Pérez, Vanja C. Douglas, María Elena Martínez Quintana, Silvia García de Castrillón i Ramal, Silvia Beretta, Mandeep Sing, Robert A Balk, Yolanda Poveda Hernández, Spencer Roberson, Martin Siegemund, Jordi Morillas Pérez, Rameela Raman, Giuseppe Servillo, João Manoel Silva, Brenda T. Pun, Aurélien Mazeraud, María Cruz Martín Delgado, Borja Hinojal Olmedillo, Gemma Gomà Fernández, Miguel Valente, Michael T. Kenes, Laura Galarza, Fabio Silvio Taccone, Wencong Chen, Rita Pereia, Álvaro Ortega Guerrero, Morgan H. Tandy, Alejandro Ruiz Perea, Stephanie Wilson-Linville, Meri Martin Cerezuela, Salvatore Lucio Cutuli, Carlos A. Calvo, María de las Nieves Noci Moreno, Ariadna Bellès, Elisa Govea Bogossian, Mario Dalorzo González, Eva Álvarez Torres, David Díaz Muñoz, Carla Margarida Teixeira, Emilio del Campo Molina, Sol Fernandez-Gonzalo, Christine Harb, Berta Monleón, Anna Teresa Mazzeo, Beatriz Del Moral Barbudo, Thomas Godet, Cristina Delgado Palacios, C. Adrian Austin, Hilde Wøien, Anselmo Caricato, Erik Roman-Pognuz, Bruno Gonçalves, Patricia Rodríguez Villamizar, Eloisa Sofia Tanzarella, Daniel A Godoy Torres, Robert E. Hosse, Lisa Smit, María Rosa Sanchis-Martin, Cristina Murcia Gubianas, Emily Sanders, Karen Herrera-Davis, Sara Torrico Sánchez, Isabel Peña Luna, David A Bennett, Irene Torres, Diana Gil-Castillejos, Laura Labrador Romero, Felipe González-Seguel, Carlos Muñoz De Cabo, Ellis Morgan, Itziar Insausti, Mónica García Simón, Patricia Piñeiro Otero, Genís Carrasco Gómez, M. Montero, Jose García Cantos, Ignacio Garutti, César Rodriguez Nuñez, Fernando Higuero, Sameep Sehgal, Catherine M. Kuza, Yago García Blanco-Traba, Juan Romeu Prieto, Ainhoa Serrano, Elena Abril Palomares, Perihan Ergin Özcan, Mathieu van der Jagt, Elena Gallego Curto, Berta Gallego Rodríguez, Rosalía Navarro Casado, Aaron Lerner, Myrto Tzimou, Sheila Moya Gutiérrez, Beatriz García Góngora, Eleonora Stival, Xavier Andorrà Sunyer, Susana Gallardo Sánchez, Anna Baró Serra, Filadelfo Bustos Molina, Rafael Zaragoza, Verónica Rojas, Paolo Pelosi, Aris Pérez Lucendo, Stéphane Legriel, Eduardo Tobar, Laura Lizama, Viviane Hidalgo-Calibin, Chiara Maria Concetta Massaro, Nekane Romero, Pablo García Domelo, Isabel Jesus Pereira, Kelly Drumright, Frank Rasulo, Mattia Marchesi, Jacques Creteur, Estefanía Carvajal Revuelta, Timothy D. Girard, Pablo Carreño-Montenegro, Ana Montero Feijoo, Ignacio Baeza Gómez, Alba Gonzalo Millán, Esteban Morcillo, Alice Santos, Pilar Leal Sanz, Dulce Morales, Gabriel Heras La Calle, Hollis R. O’Neal, Antonio Ramírez-Palma, Inés Pérez Francisco, Alberto Noto, Matilde González Serrano, Paola Valls, María Jesús Mármol Cubillo, Emilio Maseda, Anna Estermann, Andrés Pujol, E. Wesley Ely, Alexis Ferré, Lucia Chowdhury, Guillaume Lacave, Cristina Granja, Isabel de la Calle Gil, Onur M Orun, Mohamed Boussarsar, David Pestaña Lagunas, Denise Battaglini, Nathan E. Brummel, Rosa María Pérez Manrique, Núria Zellweger, Jaume Puig, Kiran Devulapally, Milagros Calizaya Vargas, Jesús Caballero, Theresa Olasveengen, Cristina Fuster, Aarti Sarwal, Pratik P. Pandharipande, Gabriele Pintaudi, Paula Ramirez, Blanca Fernández Tomás, Maria Claudia Giménez Santamarina, Francisco Luis Pérez Caballero, Enver Rodriguez-Martinez, David Martínez-Gascueña, Irene Paredes Borrachero, Ugo Fraisse, Paloma LaTorre Andreu, Ignacio Catalán-Monzón, Elena Gonzalez, Figen Esen, Lorenzo Peluso

Publikováno v: The Lancet. Respiratory Medicine
The Lancet Respiratory Medicine, 9(3), 239-250. Elsevier Ltd.
The Lancet Respiratory Medicine

Background: To date, 750 000 patients with COVID-19 worldwide have required mechanical ventilation and thus are at high risk of acute brain dysfunction (coma and delirium). We aimed to investigate the prevalence of delirium and coma, and risk factors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26f66a81083ba555e7dcc17d56833548
http://europepmc.org/articles/PMC7832119

Palliative Care Units Should Be Concerned for the Last Days of End Stage Patients Instead of Intensive Care Unit: Two Year Experience

Autor: E. Yildiz, Adnan Yilmaz, Gokay Gungor, Nalan Adiguzel, N. Kose, M. Orun, O. Oruc, U. Tanulku, Zuhal Karakurt, S. Dadas, E. Tatlidil, E. Gidik, D. Uysal

Publikováno v: D50. CRITICAL CARE: THE METAMORPHOSIS - PAIN, SEDATION, DELIRIUM, ICU-ACQUIRED WEAKNESS, AND PALLIATIVE CARE.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::762a563ea83596738989c91876fee891
https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a6689