Investigation of the Genetic Determinants of Telangiectasia and Solid Organ Arteriovenous Malformation Formation in Hereditary Hemorrhagic Telangiectasia (HHT)

Autor: Kevin J. Whitehead, Doruk Toydemir, Whitney Wooderchak-Donahue, Gretchen M. Oakley, Bryan McRae, Angelica Putnam, Jamie McDonald, Pinar Bayrak-Toydemir

Publikováno v: International Journal of Molecular Sciences, Vol 25, Iss 14, p 7682 (2024)

Telangiectases and arteriovenous malformations (AVMs) are the characteristic lesions of Hereditary Hemorrhagic Telangiectasia (HHT). Somatic second-hit loss-of-function variations in the HHT causative genes, ENG and ACVRL1, have been described in der

Externí odkaz: https://doaj.org/article/d314e09495bc492d9344eb930731d69b

Manejo integrado de aguas residuales dentro y fuera la cuenca del Lago Atitlán

Autor: Stewart M. Oakley, Pedro Saravia

Publikováno v: Agua, Saneamiento & Ambiente, Vol 16, Iss 1 (2021)

El lago Atitlán recibe aguas residuales que deterioran su calidad y amenazan la salud pública, 100,000 personas utilizan el lago como fuente de agua, sin potabilización-. Las floraciones de cianobacterias en 2009 y 2015 muestran la degradación y

Externí odkaz: https://doaj.org/article/d2e73ee000af4dc98a8ce93639219c74

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2021 Canadian Surgery Forum01. Design and validation of a unique endoscopy simulator using a commercial video game03. Is ethnicity an appropriate measure of health care marginalization?: A systematic review and meta-analysis of the outcomes of diabetic foot ulceration in the Aboriginal population04. Racial disparities in surgery — a cross-specialty matched comparison between black and white patients05. Starting late does not increase the risk of postoperative complications in patients undergoing common general surgical procedures06. Ethical decision-making during a health care crisis: a resource allocation framework and tool07. Ensuring stability in surgical training program leadership: a survey of program directors08. Introducing oncoplastic breast surgery in a community hospital09. Leadership development programs for surgical residents: a review of the literature10. Superiority of non-opioid postoperative pain management after thyroid and parathyroid operations: a systematic review and meta-analysis11. Timing of ERCP relative to cholecystectomy in patients with ductal gallstone disease12. A systematic review and meta-analysis of randomized controlled trials comparing intraoperative red blood cell transfusion strategies13. Postoperative outcomes after frail elderly preoperative assessment clinic: a single-institution Canadian perspective14. Selective opioid antagonists following bowel resection for prevention of postoperative ileus: a systematic review and meta-analysis15. Peer-to-peer coaching after bile duct injury16. Laparoscopic median arcuate ligament release: a video abstract17. Retroperitoneoscopic approach to adrenalectomy19. Endoscopic Zenker diverticulotomy: a video abstract20. Variability in surgeons’ perioperative management of pheochromocytomas in Canada21. The contribution of surgeon and hospital variation in transfusion practice to outcomes for patients undergoing elective gastrointestinal cancer surgery: a population-based analysis22. Perioperative transfusions for gastroesophageal cancers: risk factors and short- and long-term outcomes23. The association between frailty and time alive and at home after cancer surgery among older adults: a population-based analysis24. Psychological and workplace-related effects of providing surgical care during the COVID-19 pandemic in British Columbia, Canada25. Safety of venous thromboembolism prophylaxis in endoscopic retrograde cholangiopancreatography: a systematic review26. Complications and reintervention following laparoscopic subtotal cholecystectomy: a systematic review and meta-analysis27. Synchronization of pupil dilations correlates with team performance in a simulated laparoscopic team coordination task28. Receptivity to and desired design features of a surgical peer coaching program: an international survey9. Impact of the COVID-19 pandemic on rates of emergency department utilization due to general surgery conditions30. The impact of the current COVID-19 pandemic on the exposure of general surgery trainees to operative procedures31. Association between academic degrees and research productivity: an assessment of academic general surgeons in Canada32. Laparoscopic endoscopic cooperative surgery (LECS) for subepithelial gastric lesion: a video presentation33. Effect of the COVID-19 pandemic on acute care general surgery at an academic Canadian centre34. Opioid-free analgesia after outpatient general surgery: a pilot randomized controlled trial35. Impact of neoadjuvant immunotherapy or targeted therapies on surgical resection in patients with solid tumours: a systematic review and meta-analysis37. Surgical data recording in the operating room: a systematic review of modalities and metrics38. Association between nonaccidental trauma and neighbourhood socioeconomic status during the COVID-19 pandemic: a retrospective analysis39. Laparoscopic repair of a transdiaphragmatic gastropleural fistula40. Video-based interviewing in medicine: a scoping review41. Indocyanine green fluorescence angiography for prevention of anastomotic leakage in colorectal surgery: a cost analysis from the hospital payer’s perspective43. Perception or reality: surgical resident and faculty assessments of resident workload compared with objective data45. When illness and loss hit close to home: Do health care providers learn how to cope?46. Remote video-based suturing education with smartphones (REVISE): a randomized controlled trial47. The evolving use of robotic surgery: a population-based analysis48. Prophylactic retromuscular mesh placement for parastomal hernia prevention: a retrospective cohort study of permanent colostomies and ileostomies49. Intracorporeal versus extracorporeal anastomosis in laparoscopic right hemicolectomy: a retrospective cohort study on anastomotic complications50. A lay of the land — a description of Canadian academic acute care surgery models51. Emergency general surgery in Ontario: interhospital variability in structures, processes and models of care52. Trauma 101: a virtual case-based trauma conference as an adjunct to medical education53. Assessment of the National Surgical Quality Improvement Program Surgical Risk Calculator for predicting patient-centred outcomes of emergency general surgery patients in a Canadian health care system54. Sustainability of a narcotic reduction initiative: 1 year following the Standardization of Outpatient Procedure (STOP) Narcotics Study55. Barriers to transanal endoscopic microsurgery referral56. Geospatial analysis of severely injured rural patients in a geographically complex landscape57. Implementation of an incentive spirometry protocol in a trauma ward: a single-centre pilot study58. Impostor phenomenon is a significant risk factor for burnout and anxiety in Canadian resident physicians: a cross-sectional survey59. Understanding the influence of perioperative education on performance among surgical trainees: a single-centre experience60. The effect of COVID-19 pandemic on current and future endoscopic personal protective equipment practices: a national survey of 77 endoscopists61. Case report: delayed presentation of perforated sigmoid diverticulitis as necrotizing infection of the lower limb62. Investigating disparities in surgical outcomes in Canadian Indigenous populations63. Fundoplication is superior to medical therapy for Barrett esophagus disease regression and progression: a systematic review and meta-analysis64. Development of a novel online general surgery learning platform and a qualitative preimplementation analysis65. Hagfish slime exudate as a potential novel hemostatic agent: developing a standardized assessment protocol66. The effect of the first wave of the COVID-19 pandemic on surgical oncology case volumes and wait times67. Safety of same-day discharge in high-risk patients undergoing ambulatory general surgery68. External validation of the Codman score in colorectal surgery: a pragmatic tool to drive quality improvement69. Improved morbidity and gastrointestinal restoration rates without compromising survival rates for diverting loop ileostomy with colonic lavage versus total abdominal colectomy for fulminant Clostridioides difficile colitis: a multicentre retrospective cohort study70. Potential access to emergency general surgical care in Ontario71. Immersive virtual reality (iVR) improves procedural duration, task completion and accuracy in surgical trainees: a systematic review01. Clinical validation of the Canada Lymph Node Score for endobronchial ultrasound02. Venous thromboembolism in surgically treated esophageal cancer patients: a provincial population-based study03. Venous thromboembolism in surgically treated lung cancer patients: a population-based study04. Is frailty associated with failure to rescue after esophagectomy? A multi-institutional comparative analysis of outcomes05. Routine systematic sampling versus targeted sampling of lymph nodes during endobronchial ultrasound: a feasibility randomized controlled trial06. Gastric ischemic conditioning reduces anastomotic complications in patients undergoing esophagectomy: a systematic review and meta-analysis07. Move For Surgery, a novel preconditioning program to optimize health before thoracic surgery: a randomized controlled trial08. In case of emergency, go to your nearest emergency department — Or maybe not?09. Does preoperative SABR increase the risk of complications from lung cancer resection? A secondary analysis of the MISSILE trial10. Segmental resection for lung cancer: the added value of near-infrared fluorescence mapping diminishes with surgeon experience11. Toward competency-based continuing professional development for practising surgeons12. Stereotactic body radiotherapy versus surgery in older adults with NSCLC — a population-based, matched analysis of long-term dependency outcomes13. Role of adjuvant therapy in esophageal cancer patients after neoadjuvant therapy and curative esophagectomy: a systematic review and meta-analysis14. Evaluation of population characteristics on the incidence of thoracic empyema: an ecological study15. Determining the optimal stiffness colour threshold and stiffness area ratio cut-off for mediastinal lymph node staging using EBUS elastography and AI: a pilot study16. Quality assurance on the use of sequential compression stockings in thoracic surgery (QUESTs)17. The relationship between fissureless technique and prolonged air leak for patients undergoing video-assisted thoracoscopic lobectomy18. CXCR2 inhibition as a candidate for immunomodulation in the treatment of K-RAS-driven lung adenocarcinoma19. Assessment tools for evaluating competency in video-assisted thoracoscopic lobectomy: a systematic review20. Understanding the current practice on chest tube management following lung resection among thoracic surgeons across Canada21. Effect of routine jejunostomy tube insertion in esophagectomy: a systematic review and meta-analysis22. Recurrence of primary spontaneous pneumothorax following bullectomy with pleurodesis or pleurectomy: a retrospective analysis23. Surgical outcomes following chest wall resection and reconstruction24. Outcomes following surgical management of primary mediastinal nonseminomatous germ cell tumours25. 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Surgical treatment of esophageal cancer: trends in surgical approach and early mortality at a single institution over the past 18 years34. Adverse events and length of stay following minimally invasive surgery in paraesophageal hernia repair35. Long-term symptom control comparison of Dor and Nissen fundoplication following laparoscopic para-esophageal hernia repair: a retrospective analysis36. Willingness to pay: a survey of Canadian patients’ willingness to contribute to the cost of robotic thoracic surgery37. Radiomics in early-stage lung adenocarcinoma: a prediction tool for tumour immune microenvironments38. Effectiveness of intraoperative pyloric botox injection during esophagectomy: how often is endoscopic intervention required?39. An artificial intelligence algorithm for predicting lymph node malignancy during endobronchial ultrasound40. The effect of major and minor complications after lung surgery on length of stay and readmission41. 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Sexuality and rectal cancer treatment: a qualitative study exploring patients’ information needs and expectations on sexual dysfunction after rectal cancer treatment17. Video-based interviews in selection process18. Impact of delaying colonoscopies during the COVID-19 pandemic on colorectal cancer detection and prevention19. Opioid use disorder associated with increased anastomotic leak and major complications after colorectal surgery20. Effectiveness of a rectal cancer education video on patient expectations21. Robotic-assisted rectosigmoid and rectal cancer resection: implementation and early experience at a Canadian tertiary centre22. An online educational app for rectal cancer survivors with low anterior resection syndrome: a pilot study23. The effects of surgeon specialization on the outcome of emergency colorectal surgery24. Outcomes after colorectal cancer resections in octogenarians and older in a regional New Zealand setting — What are the predictors of mortality?25. Long-term outcomes after seton placement for perianal fistulae with and without Crohn disease26. A survey of patient and surgeon preference for early ileostomy closure following restorative proctectomy for rectal cancer — Why aren’t we doing it?27. Crohn disease independently associated with longer hospital admission after surgery28. Short-stay (≤ 1 d) diverting loop ileostomy closure can be selectively implemented without an increase in readmission and complication rates: an ACS-NSQIP analysis29. A comparison of perineal stapled rectal prolapse resection and the Altemeier procedure at 2 Canadian academic hospitals30. Mental health and substance use disorders predict 90-day readmission and postoperative complications following rectal cancer surgery31. Early discharge after colorectal cancer resection: trends and impact on patient outcomes32. 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Racial, ethnic and socioeconomic disparities in diagnosis, treatment and survival of patients with breast cancer: a SEER-based population analysis02. First-line palliative chemotherapy for esophageal and gastric cancer: practice patterns and outcomes in the general population03. Frailty as a predictor for postoperative outcomes following pancreaticoduodenectomy04. Synoptic electronic operative reports identify practice variation in cancer surgery allowing for directed interventions to decrease variation05. The role of Hedgehog signalling in basal-like breast cancer07. Clinical and patient-reported outcomes in oncoplastic breast conservation surgery from a single surgeon’s practice in a busy community hospital in Canada08. Upgrade rate of atypical ductal hyperplasia: 10 years of experience and predictive factors09. Time to first adjuvant treatment after oncoplastic breast reduction10. Preparing to survive: improving outcomes for young women with breast cancer11. 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Autor: M. Connell, W. Lin, A. Jarrar, A. Mierzwa, J. Shiroky, Z. Cloutier, F. Deaninck, W. He, Y. Lee, S. Keshavjee, M. Fortin, C. McLean, M. Melland-Smith, J. Frigault, G. Chartrand, N. Zuker, S. Elbekri, Z. Mir, R. Gilbert, V. Smith, H. Shrader, Y. Essaji, A. Webb, J. Glinka, E. Waugh, L. Park, M. Lund, M. Lemke, D. Henault, J. Zuckerman, N. Hanna, F. Reyna-Sepulveda, T. Lenet, K. Verhoeff, M. Parapini, D. Lim, S. Langer, D. Nguyen, C. Mardinger, A. Allard-Coutu, D. Cyr, K. Allen, D. Ng, L. Cadili, H. Kapur, S. Mysuria, É. Di Lena, V. Pravong, A. Alqaydi, A. Hunter-Smith, N. Gagnon, A. DiPasquale, W. Marini, M. Jacobson, V. Li, S. Merchant, A. Azin, R. Szwimer, N. Kasteel, E. Papillon, N. Alghaithi, M. Hegagi, Z. Harra, V. Wiseman, E. Salama, J. Moon, H. Roy, J. Liang, Z. Bayat, N. Caminsky, M.K. Motamedi, R. Ruxton, O. AlAamer, O. Monton, M. Li, C. Brown, J. Holland, R. Selvam, V. Brissette, T. McKechnie, H. AlSulaim, G. Talwar, R. Garfinkle, K. Purich, R. Hajjar, C. Cahill, G. Johnson, A. Bruinooge, K. Graham, H. Wang, M. Robinson, V. Gupta, E. Peters, L. Qu, D. Jones, C. Finley, I. Churchill, N. Hunka, M. Kaafarani, Y. Patel, D. Le Nguyen, S. Abdul, M. Humer, D. Sisson, A. Al Rawahi, C. Huynh, B. Greenberg, Y. Shargall, S. Turner, A. Alghamedi, V. Resende, S. Brophy, L. Esther, A. Kammili, M. De Meo, R. Razzak, N. Mistry, R. Nayak, D. Hirpara, J. Alaichi, A. Ednie, M. Abbas, U. Jogiat, K. Sullivan, G. Akhtar-Danesh, R. He, L. Lan, K. Larsen, M. Abou Khalil, K. Guidolin, G. Pang, J. Drung, C. Li, H. Wilson, N. Patro, E. Schmitz, W. Sun, R. Liu, C. Dwyer, R. Raskin, R. Wigen, K. Singh, G. Skelhorne-Gross, A. Rosenzveig, H. Muaddi, K. Ren, A. Lee, E. Walser, H. Forbes, C. Kruse, P.E. Serrano Aybar, U. Do, D. Skubleny, A. Fecso, A. Miles, S. Balvardi, L. Lee, L. Kerr, L. Glass, K. D’Souza, M. Nguyen, A. Zhu, K. Nabata, E. Ertel, R. Guo, J. Gentles, F. Shariff, K. Hickey, A. Vergis, B. Unger, J. Park, L. Gillman, D. Pace, K. Lam-Tin-Cheung, S. Chadi, F. Quereshy, J. Catton, B. Rubin, J. Bell, J. Marangos, A. Heesters, T. Stuart-McEwan, F. Wright, N. Ahmed, A. Nadler, J. Hallet, L. Chen, H. Hwang, R. Sidhu, T. Scott, A. Karimuddin, A. Nguyen, J. Osborn, S. Wiseman, L. Baker, M. Vered, A. Zahrai, R. Shorr, A. Davis, D. McIsaac, A. Tinmouth, D. Fergusson, G. Martel, S. Rummel, M. Stefic-Cubic, M. Stewart, A. Melck, T. Anpalagan, S. Ichhpuniani, K. Ramji, C. Eskicioglu, S. Deng, B. Greene, M. Tsang, V. Palter, S. Jayaraman, A. Mann, J. Tittley, M. Cadeddu, A. Madani, J. Pasternak, D. Hong, A. Istl, E. Tang, D. Gray, N. Coburn, J. Callum, R. McLeod, E. Pearsall, Y. Lin, A. Turgeon, A. Mahar, P. Kriviraltcheva-Kaneva, J. Cools-Lartigue, L. Ferri, C. Mueller, B. Haas, B. Tillman, M. Guttman, T. Chesney, V. Zuk, A. Hsu, W. Chan, R. Vasdev, L. Cadili J. Ling, R. Warburton, M. Hameed, H. Williamson, P. Murphy, K. Leslie, J. Hawel, S. Zablotny, H. Roldan, X. Jiang, B. Zheng, J. Fiore, L. Feldman, G. Fried, S. Valanci, J. Cipolla, P. Kaneva, S. Demyttenaere, M. Boutros, M. Alhashemi, J. Shapiro, D. Bigam, J. Kung, J. Mosko, P. Hamilton, S. Ghosh, S. Widder, D. Schiller, C. El Kefraoui, M. Pook, N. Barone, H. Montgomery, P. Nguyen-Powanda, F. Rajabiyazdi, H. Elhaj, M. Lapointe-Gagner, G. Olleik, A. Antoun, N. Safa, E. Di Lena, S. Meterissian, A. Meguerditchian, F. Lee, G. Baldini, S. Parpia, L. Ruo, K. Tywonek, S. Lee, C. O’Neill, N. Faisal, A. Alfayyadh, M. Gundayao, B.M. Meyers, R. Habashi, M. Levin, K. Aldrich, T. Grantcharov, A. Langerman, R. Anantha, V. Fawcett, A. Hetherington, M. Gervais, G. Rakovich, R. Hu, R. Musselman, I. Raiche, H. Moloo, A. Elnahas, N. Alkhamesi, A. Alnumay, C. Schlachta, C. Zhang, S. Cristancho, M. Ott, B. Niu, F. Balaa, N. Gawad, Y. Qiu, K. Hamann, N. How, C. Leveille, A. Davidson, A. Eqbal, Y. Sardiwalla, M. Korostensky, E. Lee, I. Yang, T. Stukel, C. de Mestral, A. Nathens, P. Karanicolas, S. Lemieux, D. Breton, P. Bouchard, A. Bouchard, R. Grégoire, F. Letarte, G. Bouchard, S. Drolet, S. 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Anvari, O. Lovrics, I. Aditya, A. Khondker, M. Walsh, K. Hardy, R. Romanescu, J. Linton, M. Fowler-Woods, A. Fowler-Woods, G. Shingoose, M. Zmudzinski, V. Archer, J. Abu Halimah, V. Boudreau, G. Marcil, A. Hardy-Henry, J. Hagen

Publikováno v: Canadian Journal of Surgery. 64:S80-S159

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eca3206107f330dbb544b0cecb24e9ab
https://doi.org/10.1503/cjs.021321