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Autor:
M. O. Wright, I. J. Lauder
Publikováno v:
Clinical Genetics. 6:205-215
Measurements were made of the maximum motor nerve conduction in the median and ulnar nerves of the right forearm for the four sex chromosomally abnormal groups 47, XXY and 48, XXYY males, 47, XXX and 45, X females. The results obtained were compared
Publikováno v:
Osteoarthritis and Cartilage. 14:991-1001
Summary Objective To identify functional interleukin-4 (IL4) receptor (IL4R) subtypes and associated Janus kinase/signal transducers and activators of transcription (JAK/STAT) molecules in human articular chondrocytes and assess the role of JAK/STAT
Publikováno v:
Rheumatology. 43:1226-1231
OBJECTIVES: Methotrexate (MTX), which is prescribed in the treatment of malignancy and autoimmune disease, has detrimental effects on a number of organ systems, including bone. At present, the exact mechanism of action of MTX on bone at the cellular
Publikováno v:
Clinical Orthopaedics and Related Research. 391:S49-S60
Mechanical stimuli are known to have major influences on chondrocyte function. The molecular events that regulate chondrocyte responses to mechanical stimulation are beginning to be understood. In vitro analyses have allowed identification of mechano
Publikováno v:
Arthritis & Rheumatism. 43:2091-2099
Objective. To determine molecular events in the regulation of messenger RNA (mRNA) of cartilage matrix molecules and proteases by mechanical stimulation of chondrocytes from normal human articular cartilage and to ascertain whether similar regulatory
Publikováno v:
Journal of Bone and Mineral Research. 15:1746-1755
Mechanical stimuli imparted by stretch, pressure, tension, fluid flow, and shear stress result in a variety of biochemical responses important in bone (re)modeling. The molecules involved in the recognition and transduction of mechanical stimuli that
Publikováno v:
Osteoarthritis and Cartilage. 8(4):272-278
Objective To establish whether chondrocytes from normal and osteoarthritic human articular cartilage recognize and respond to pressure induced mechanical strain in a similar manner. Design Chondrocytes, extracted from macroscopically normal and osteo
Autor:
M O Wright, Keiichiro Nishida, Donald Salter, George Nuki, H.-S. Lee, S J Millward-Sadler, H Caldwell
Publikováno v:
The Journal of Cell Biology
Chondrocyte function is regulated partly by mechanical stimulation. Optimal mechanical stimulation maintains articular cartilage integrity, whereas abnormal mechanical stimulation results in development and progression of osteoarthritis (OA). The res