Zobrazeno 1 - 10
of 15
pro vyhledávání: '"M. O. Spycher"'
Publikováno v:
Scopus-Elsevier
SUMMARYPolyspecific IgG given intravenously at high doses (IVIG) is used for immunomodulatory therapy in autoimmune diseases such as idiopathic thrombocytopenic purpura and myasthenia gravis. It is assumed that the clinical effect is brought about in
Autor:
M. O. Spycher, P.J. Späth
Publikováno v:
Vox Sanguinis. 59:44-50
A sensitive flow-cytometric method was established to quantify the number of complement receptor 1 (CR1, C3b/C4b receptor, CD35) on the surface of purified erythrocytes of 12 patients infected by HIV-1 and showing two clinical AIDS-related complex/Wa
Publikováno v:
Transfusion medicine (Oxford, England). 14(2)
In this first-in-man study, we assessed the pharmacokinetics, safety and tolerability of MonoRho, a human recombinant monoclonal anti-RhD immunoglobulin G1 (IgG1) antibody. Eighteen RhD-negative healthy male volunteers were randomized in two groups t
Autor:
S, Miescher, M, Vogel, C, Biaggi, V, Ramseyer, H, Hustinx, N, Eicher, M A, Imboden, M O, Spycher, H, Amstutz, B M, Stadler
Publikováno v:
Vox sanguinis. 75(4)
Hyperimmune anti-Rh D serum is worldwide in short supply. As a first step to develop an alternative source of Rh D antibodies, we describe in this study the isolation and characterization of recombinant anti-Rh D Fab fragments.Peripheral blood mononu
Publikováno v:
Thrombosis and haemostasis. 80(2)
A reconstituted high density lipoprotein (rHDL) prepared for clinical use was tested for its influence on platelet activity modulated by various stimuli. In a first series of in vitro experiments, rHDL was added to blood in a concentration series, an
Publikováno v:
Immunology. 71(1)
A panel of monoclonal antibodies (mAb) directed against human monocyte surface antigens was tested for their capacity to mediate signal transduction by measuring luminol-enhanced chemiluminescence (CL). The response patterns fell into three categorie
Autor:
M O, Spycher, P J, Späth
Publikováno v:
Vox sanguinis. 59
A sensitive flow-cytometric method was established to quantify the number of complement receptor 1 (CR1, C3b/C4b receptor, CD35) on the surface of purified erythrocytes of 12 patients infected by HIV-1 and showing two clinical AIDS-related complex/Wa
Autor:
M O, Spycher, U E, Nydegger
Publikováno v:
Blood. 67:12-18
The differential uptake of tritium-labeled immunoglobulin G (IgG) cross- linked with bisdiazonium-benzidine (BDB) (3H-BDB-IgG) by washed, pooled human platelets to sites inaccessible to pronase digestion was tested. Up to 52% of the 3H-BDB-IgG associ
Publikováno v:
The Journal of Immunology. 141:457-463
We sought biochemical evidence for a role of C receptors types 1 (CR1) and 2 (CR2) in B cell activation. A flow cytometer was used to measure the fluorescence of tonsillar cells that had been loaded with the calcium-dependent indicator indo-1, and ce
Publikováno v:
British Journal of Haematology. 64:299-307
The effect of purified human plasma fibronectin on stimulation of human platelets with crosslinked immunoglobulin G (IgG) was tested by means of aggregometry, 14C-serotonin release and fibronectin-to-platelet binding experiments. Incremental addition