Zobrazeno 1 - 10
of 133
pro vyhledávání: '"M. Nicolodi"'
Publikováno v:
Headache: The Journal of Head and Face Pain. 42:596-602
The antinociceptive activity of donepezil, a novel cholinesterase inhibitor, was investigated in the mouse hot plate test. Donepezil (5 to 10 mg kg(-1) i.p.) induced a dose-dependent antinociception that reached its maximum effect 15 minutes after in
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Autor:
M, Nicolodi, F, Sicuteri
Publikováno v:
Advances in experimental medicine and biology. 467
Recently synthesized triptans, sumatriptan derivatives, display aborting migraine activity at doses and with plasmatic maximum peak dramatically lower (20-40 times) than sumatriptan, the 5-HT like agonist, which is the original molecule. That triptan
Autor:
M, Nicolodi, F, Sicuteri
Publikováno v:
Advances in experimental medicine and biology. 467
Prevention of primary pain is a new topic, endowed with social and economic interest. We observed that L-5-HTP can induce a significant decrease of the cropping out of migraine, the commonest primary pain. This finding seems interesting, since it rep
Autor:
M, Nicolodi, F, Sicuteri
Publikováno v:
Drugs under experimental and clinical research. 25(2-3)
According to popular belief, alcoholic beverages are to be avoided in the case of headache, a term which includes migraine, the most common type of headache. An imbalance between pain transmission and inhibition has been suggested and partly proved t
Autor:
M, Nicolodi
Publikováno v:
International journal of clinical pharmacology research. 18(2)
Having a differential sensitivity to morphine can distinguish migraine suffers from healthy people who are headache-exempt. The aim of the present study was to investigate whether such an abnormal response to morphine challenge is entirely dependent
Publikováno v:
International journal of clinical pharmacology research. 17(2-3)
The antinociceptive effect of the antimigraine drug sumatriptan was assessed in mice (hot-plate and abdominal constriction tests). Antinociception induced by sumatriptan (10-30 mg kg-1 i.p.) was prevented by the muscarinic antagonist atropine (5 mg k
Publikováno v:
International journal of clinical pharmacology research. 17(2-3)
Bradykinin, histamine and serotonin were the most active physiological agonists in increasing jugular levels of nitric oxide when administered into the left common carotid artery of anaesthetized rabbits. Bradykinin potentiated selectively the effect
Publikováno v:
International journal of clinical pharmacology research. 17(2-3)
The use of antagonists of N-methyl-D-aspartate (NMDA) receptors, or the administration of inhibitors of the synthesis or of the release of excitatory amino acids, enables the analgesic drug-dependence associated with chronic daily migraine to be over
Publikováno v:
International journal of clinical pharmacology research. 17(2-3)
5-HT is currently indicated to play a role in migraine (M). Previously evidenced 5-HT supersensitivity which characterizes M is insufficient to compensate for a possible deficit in 5-HT bioavailability. Inducing a further up-regulation of 5-HT recept