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EP1 receptor blockade attenuates both spontaneous tone and PGE2-elicited contraction in guinea pig trachealis

Autor: I. M. Ndukwu, Steven R. White, Alan R. Leff, Richard W. Mitchell

Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology. 273:L626-L633

We assessed the effect of prostaglandin (PG) E2 on tone of guinea pig tracheal smooth muscle (TSM) strips in vitro. In the presence of spontaneous tone [ST; i.e., no indomethacin (-Indo)], exogenous PGE2 caused a significant relaxation of ST at conce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd11938164156eca25bb00570f559c46
https://doi.org/10.1152/ajplung.1997.273.3.l626

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Differential tachykinin receptor subtype activation in capsaicin and KCl contractions of guinea pig trachealis

Autor: I. M. Ndukwu, K. Uzendoski, Alan R. Leff, A. Herrnreiter, Julian Solway, Richard W. Mitchell, B. Gitter

Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology. 269:L837-L842

We assessed the role of endogenously secreted tachykinins in mediating contraction caused by potassium chloride (KCl) in guinea pig tracheal smooth muscle (TSM) strips in vitro. Maximal isometric contraction was elicited with approximately 45 mM KCl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a79cee0a1c8716d3765fcb214a83eea4
https://doi.org/10.1152/ajplung.1995.269.6.l837

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Immune sensitization augments epithelium-dependent spontaneous tone in guinea pig trachealis

Autor: Julian Solway, K. Uzendoski, Alan R. Leff, K. Arbetter, I. M. Ndukwu, Richard W. Mitchell

Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology. 266:L485-L492

We examined epithelial modulation of tracheal smooth muscle (TSM) responsiveness in vitro from guinea pigs receiving active immune sensitization in vivo. Initially, guinea pigs were either ovalbumin sensitized (by aerosol) or sham sensitized with nor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7cbea2a39675f139753b2204a783292
https://doi.org/10.1152/ajplung.1994.266.5.l485

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Effect of airway inflammation on smooth muscle shortening and contractility in guinea pig trachealis

Autor: K. Arbetter, Alan R. Leff, Richard W. Mitchell, I. M. Ndukwu, Julian Solway

Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology. 265:L549-L554

We studied the effect of either 1) immunogenic inflammation caused by aerosolized ovalbumin or 2) neurogenic inflammation caused by aerosolized capsaicin in vivo on guinea pig tracheal smooth muscle (TSM) contractility in vitro. Force-velocity relati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4db75f1fe8442ccebdfa90c7af7a350
https://doi.org/10.1152/ajplung.1993.265.6.l549

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Physiologic Significance of Epithelial Removal on Guinea Pig Tracheal Smooth Muscle Response to Acetylcholine and Serotonin

Autor: Alan R. Leff, F. S. Williams, Richard W. Mitchell, Steven R. White, A J Vita, Nilda M. Munoz, I. M. Ndukwu, Mary E. Strek

Publikováno v: American Review of Respiratory Disease. 147:1477-1482

We studied the modulatory effect of airway epithelium on guinea pig tracheal smooth muscle (TSM) contraction. Isometric force was measured in vivo before and after removal of the tracheal epithelium. In parallel studies, TSM contraction was also meas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e59736a314bbfd714b1e0600e76c589
https://doi.org/10.1164/ajrccm/147.6_pt_1.1477

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Relationship of cellular transmigration and airway response after allergen challenge

Autor: Christopher Maxwell, Michael Waldman, Alan R. Leff, I. M. Ndukwu, Edward T. Naureckas

Publikováno v: American journal of respiratory and critical care medicine. 160(5 Pt 1)

We examined the relationship between eosinophil migration into the bronchoalveolar space and change in FEV(1) after endobronchial allergen challenge (EBAC) in atopic asthmatic (AA) and atopic nonasthmatic (ANA) subjects. The purpose of this study was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18798cd4a044661a4fcbe54fc97a08f2
https://pubmed.ncbi.nlm.nih.gov/10556114

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Near-fatal heat stroke during the 1995 heat wave in Chicago

Autor: T McNamee, Sean M. Forsythe, I. M. Ndukwu, Jane Dematte, Cynthia G. Whitney, K. O'Mara, R. B. Adiga, J Buescher

Publikováno v: Annals of internal medicine. 129(3)

In July 1995, Chicago sustained a heat wave that resulted in more than 600 excess deaths, 3300 excess emergency department visits, and a substantial number of intensive care unit admissions for near-fatal heat stroke.To describe the clinical features

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed3ddb64e34e36a600c5a55fbbd939db
https://pubmed.ncbi.nlm.nih.gov/10189338

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Differential effects of cyclosporine A after acute antigen challenge in sensitized cats in vivo and ex vivo

Autor: R W, Mitchell, P, Cozzi, I M, Ndukwu, S, Spaethe, A R, Leff, P A, Padrid

Publikováno v: British journal of pharmacology. 123(6)

1. We determined the effect of cyclosporine A (CsA) treatment on mast cell degranulation and lung resistance (R(L)) in vivo, and tracheal smooth muscle (TSM) contraction ex vivo after antigen challenge in sensitized cats. We also determined the direc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c4784f32123f1a58eb91d50c3e0cbf14
https://pubmed.ncbi.nlm.nih.gov/9559905

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