Zobrazeno 1 - 10
of 199
pro vyhledávání: '"M. Nakafuku"'
Autor:
Aaron A. Thompson, Michael B. Harbut, Pei-Pei Kung, Nathan K. Karpowich, Jeffrey D. Branson, Joanna C. Grant, Deborah Hagan, Heather A. Pascual, Guoyun Bai, Reza Beheshti Zavareh, Heather R. Coate, Bernard C. Collins, Marjorie Côte, Christine F. Gelin, Kelly L. Damm-Ganamet, Hadi Gholami, Adam R. Huff, Luis Limon, Kevin J. Lumb, Puiying A. Mak, Kohki M. Nakafuku, Edmund V. Price, Amy Y. Shih, Mandana Tootoonchi, Nadeem A. Vellore, Jocelyn Wang, Na Wei, Jeannie Ziff, Scott B. Berger, James P. Edwards, Agnès Gardet, Siquan Sun, Jennifer E. Towne, Jennifer D. Venable, Zhicai Shi, Hariharan Venkatesan, Marie-Laure Rives, Sujata Sharma, Brock T. Shireman, Samantha J. Allen
Publikováno v:
Proceedings of the National Academy of Sciences. 120
NKG2D (natural-killer group 2, member D) is a homodimeric transmembrane receptor that plays an important role in NK, γδ + , and CD8 + T cell-mediated immune responses to environmental stressors such as viral or bacterial infections and oxidative st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4d48b50bde14ca39eb944d361970a99
https://doi.org/10.1073/pnas.2216342120
https://doi.org/10.1073/pnas.2216342120
Autor:
Ethan A. Wappes, Kohki M. Nakafuku, Leah M. Stateman, Andrew D. Chen, Zuxiao Zhang, David A. Nagib
Publikováno v:
Nature chemistry
Asymmetric, radical C–H functionalizations are rare, yet powerful tools for solving modern synthetic challenges. Specifically, the enantio- and regio-selective C–H amination of alcohols to access medicinally valuable, chiral β-amino alcohols rem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::885778eebdbf3909cab3b605dd52b052
https://doi.org/10.1038/s41557-020-0482-8
https://doi.org/10.1038/s41557-020-0482-8
Autor:
Kohki M. Nakafuku, Ethan A. Wappes, Darsheed N. Mustafa, David A. Nagib, Andrew D. Chen, James H. Herbort
Publikováno v:
Chemical Science. 11:2479-2486
A radical cascade strategy for the modular synthesis of five-membered heteroarenes (e.g. oxazoles, imidazoles) from feedstock reagents (e.g. alcohols, amines, nitriles) has been developed. This double C–H oxidation is enabled by in situ generated i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c40a5b7b0481a8cbc2cabc8fa8dc44c
https://doi.org/10.1039/c9sc06239d
https://doi.org/10.1039/c9sc06239d
Autor:
Andrew D, Chen, James H, Herbort, Ethan A, Wappes, Kohki M, Nakafuku, Darsheed N, Mustafa, David A, Nagib
Publikováno v:
Chemical Science
A radical cascade strategy for the modular synthesis of five-membered heteroarenes (e.g. oxazoles, imidazoles) from feedstock reagents (e.g. alcohols, amines, nitriles) has been developed. This double C–H oxidation is enabled by in situ generated i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::56f78776b20f21cb0c4934f826f2c697
https://pubmed.ncbi.nlm.nih.gov/34084413
https://pubmed.ncbi.nlm.nih.gov/34084413
Autor:
Kayambu Namitharan, Raymond K. Twumasi, David A. Nagib, Kohki M. Nakafuku, Avassaya Vanitcha, Ethan A. Wappes, Mathieu Bekkaye
Publikováno v:
J Org Chem
The design of a radical relay chaperone to promote selective C-H functionalizations is described. A saccharine-based imine was found to be uniquely suited to effect C-H amination of alcohols via an in situ generated hemiaminal. This radical chaperone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af54c26ed3c297a7da3134713364791d
https://doi.org/10.1021/acs.joc.9b02052
https://doi.org/10.1021/acs.joc.9b02052
Publikováno v:
Chemical Science. 10:2693-2699
The first catalytic strategy to harness imidate radicals for C–H functionalization has been developed. This iodine-catalyzed approach enables β C–H amination of alcohols by an imidate-mediated radical relay. In contrast to our first-generation,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e23145af0a8d268242f14f5ba0dd1d6a
https://doi.org/10.1039/c8sc05685d
https://doi.org/10.1039/c8sc05685d
Publikováno v:
Journal of the American Chemical Society. 139:10204-10207
A radical-mediated strategy for β C–H amination of alcohols has been developed. This approach employs a radical relay chaperone, which serves as a traceless director that facilitates selective C–H functionalization via 1,5-hydrogen atom transfer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7abcbdee23ef8e9a2f256cf922c4b866
https://doi.org/10.1021/jacs.7b05214
https://doi.org/10.1021/jacs.7b05214
Publikováno v:
Journal of the American Chemical Society. 140(36)
The first catalytic strategy to harness imidate radicals has been developed. This approach enables alkene difunctionalization of allyl alcohols by photocatalytic reduction of their oxime imidates. The ensuing imidate radicals undergo consecutive intr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dd3543f4db5298787d95876bff21bb1
https://pubmed.ncbi.nlm.nih.gov/30156404
https://pubmed.ncbi.nlm.nih.gov/30156404
Publikováno v:
Synthesis. 50(8)
The selective functionalization of remote C–H bonds via intramolecular hydrogen atom transfer (HAT) is transformative for organic synthesis. This radical-mediated strategy provides access to novel reactivity that is complementary to closed-shell pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ed1f79c65e64d8a33738fa4ff5b1a22
https://pubmed.ncbi.nlm.nih.gov/29755145
https://pubmed.ncbi.nlm.nih.gov/29755145
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