Zobrazeno 1 - 10
of 12
pro vyhledávání: '"M. N. Tzimas"'
Autor:
William Brian, Eric Garver, Margaret E. Sorenson, Edward F. Webb, Don E. Griswold, Ravi Shanker Garigipati, Jerry L. Adams, Marie Chabot-Fletcher, Schmidt Stanley J, J F Newton, M. N. Tzimas, Lee Ann P. Yodis, John J. Breton, Kathy A. Tyrrell
Publikováno v:
Journal of Medicinal Chemistry. 39:5035-5046
A series of N-hydroxyurea derivatives have been prepared and examined as inhibitors of 5-lipoxygenase. Oral activity was established by examining the inhibition of LTB4 biosynthesis in an ex vivo assay in the mouse. The pharmacodynamic performance in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4747a24081182d48db64046b99fccc9e
https://doi.org/10.1021/jm960271d
https://doi.org/10.1021/jm960271d
Autor:
Robert K. Clark, Raymond F. White, William J. Price, Frank C. Barone, D. E. Griswold, Giora Z. Feuerstein, D. B. Schmidt, H. M. Sarau, L. M. Hillegass, M. N. Tzimas, J. J. Foley
Publikováno v:
Molecular and Chemical Neuropathology. 24:13-30
In previous studies, we have used histological methods to characterize cellular changes, and validated the use of the myeloperoxidase (MPO) activity assay to quantitate increased neutrophil infiltration in ischemic stroke. We also identified increase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19b699730e84cdb5c5936e85a0c1a35b
https://doi.org/10.1007/bf03160109
https://doi.org/10.1007/bf03160109
Autor:
James J. Foley, Han-Liang Zhou, Marie Chabot-Fletcher, M. N. Tzimas, James D. Winkler, Henry M. Sarau, T. J. Torphy
Publikováno v:
Biochemical Pharmacology. 46:139-148
We have explored the role of phospholipase D (PLD) activation in leukotriene B4 (LTB4)-induced Ca2+ mobilization and degranulation of human neutrophils. Stimulation of [3H]alkyl-acyl-phosphatidylcholine-labeled neutrophils with LTB4 resulted in a rap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cb2b2f8d8956ea9dad82657f616129f
https://doi.org/10.1016/0006-2952(93)90358-4
https://doi.org/10.1016/0006-2952(93)90358-4
Autor:
Edward F. Webb, John J. Breton, J F Newton, Eric Garver, M. N. Tzimas, William Brian, Don E. Griswold, Margaret E. Sorenson, Lee Ann P. Yodis, Kathy A. Tyrrell, Ravi Shanker Garigipati, Jerry L. Adams, Marie Chabot-Fletcher, Schmidt Stanley J
Publikováno v:
ChemInform. 28
A series of N-hydroxyurea derivatives have been prepared and examined as inhibitors of 5-lipoxygenase. Oral activity was established by examining the inhibition of LTB4 biosynthesis in an ex vivo assay in the mouse. The pharmacodynamic performance in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1928e0a62ca8d266b09f8f295652203
https://doi.org/10.1002/chin.199716146
https://doi.org/10.1002/chin.199716146
Autor:
Robert A. Daines, Israil Pendrak, James J. Foley, Don E. Griswold, Dulcie B. Schmidt, Lenox D. Martin, Dalia R. Jakas, M. N. Tzimas, Chambers Pamela Anne, Henry M. Sarau
Publikováno v:
Journal of Medicinal Chemistry. 36:2703-2705
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f911da0c261da68aea17434d7d40491
https://doi.org/10.1021/jm00070a015
https://doi.org/10.1021/jm00070a015
Autor:
Grace I. Wells, M. N. Tzimas, Peter R. Young, Elizabeth A. Capper, Michael L. Doyle, Ruth Tal-Singer, Peter C. McDonnell, Sanjay Kumar, Lauren A. Tierney, Ruth Lehr, Don E. Griswold
Publikováno v:
The Journal of biological chemistry. 275(14)
Interleukin-1 (IL-1), fibroblast growth factors (FGFs), and their homologues are secreted factors that share a common beta-barrel structure and act on target cells by binding to cell surface receptors with immunoglobulin-like folds in their extracell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ae0219e8858c53e16ace7197aaf3d3c
https://pubmed.ncbi.nlm.nih.gov/10744718
https://pubmed.ncbi.nlm.nih.gov/10744718
Publikováno v:
Biochemical and biophysical research communications. 235(3)
ST2/T1 is an orphan receptor highly homologous to the IL-1 receptor. Using ST2 cDNA, ST2 specific primers, and a polyclonal antibody generated against ST2, the expression of mRNA and protein corresponding to both the soluble and membrane anchored for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::786eedf12531d86a63dc965491d00027
https://pubmed.ncbi.nlm.nih.gov/9207179
https://pubmed.ncbi.nlm.nih.gov/9207179
Autor:
H M, Sarau, J J, Foley, D B, Schmidt, M N, Tzimas, L D, Martin, R A, Daines, P A, Chambers, W D, Kingsbury, D E, Griswold
Publikováno v:
Advances in prostaglandin, thromboxane, and leukotriene research. 23
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9827b6e2b45fc12cdb333ef00e084182
https://pubmed.ncbi.nlm.nih.gov/7732852
https://pubmed.ncbi.nlm.nih.gov/7732852
Autor:
M. N. Tzimas, James D. Winkler, Matthew E. Kennedy, Stanley T. Crooke, James J. Foley, Henry M. Sarau
Publikováno v:
Biology of Cellular Transducing Signals ISBN: 9781461278665
Substantial progress has been made over the last several years in understanding leukotriene (LT)D4 receptors and the signal transduction process (Crooke et al., 1988; Crooke et al., 1989). LTD4 interacts with highly selective, specific receptors for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4767a54a744bcc77be160feae3a22ebd
https://doi.org/10.1007/978-1-4613-0559-0_24
https://doi.org/10.1007/978-1-4613-0559-0_24
Autor:
D. E. Griswold, M. N. Tzimas
Publikováno v:
Inflammation Research. 44:S209-S210
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8af66d44735be02ef70fdedda0798d5d
https://doi.org/10.1007/bf01778337
https://doi.org/10.1007/bf01778337