Výsledky vyhledávání

A validated HPLC assay for the determination of R-(−)-gossypol in human plasma and its application in clinical pharmacokinetic studies

Autor: Hongxia Lin, Ah-Ng Tony Kong, Murugesan Gounder, M. N. Stein, Joseph R. Bertino, Robert S. DiPaola

Publikováno v: Journal of Pharmaceutical and Biomedical Analysis. 66:371-375

R-(-)-gossypol acetic acid (AT-101), a natural BH3 mimetic, is investigated in a Phase I/II clinical trial for the treatment of advanced solid tumor malignancies. Gossypol undergoes rapid degradation in solution phase, which causes major technical di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c657241aa1c6724725ac73ce480c64b
https://doi.org/10.1016/j.jpba.2012.03.029

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Effect of dual inhibition of apoptosis and autophagy in prostate cancer

Autor: Ahamed Saleem, Eileen White, Urmila Santanam, Dmitri Dvorzhinski, Kevin Bray, M. N. Stein, Robert S. DiPaola, Robin Mathew

Publikováno v: The Prostate. 72:1374-1381

PURPOSE Targeting multiple anti-apoptotic proteins is now possible with the small molecule BH3 domain mimetics such as ABT-737. Given recent studies demonstrating that autophagy is a resistance mechanism to multiple therapeutic agents in the setting

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a60d56f289853d12b1350ea78b621210
https://doi.org/10.1002/pros.22487

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A validated bioanalytical HPLC method for pharmacokinetic evaluation of 2-deoxyglucose in human plasma

Autor: Murugesan Gounder, Susan Goodin, Ah-Ng Tony Kong, Robert S. DiPaola, Joseph R. Bertino, M. N. Stein, Hongxia Lin

Publikováno v: Biomedical Chromatography. 26:650-654

2-Deoxyglucose (2-DG), an analog of glucose, is widely used to interfere with glycolysis in tumor cells and studied as a therapeutic approach in clinical trials. To evaluate the pharmacokinetics of 2-DG, we describe the development and validation of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::99fbe75f47487f032c4e22c4c362d9f4
https://doi.org/10.1002/bmc.1710

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Targeting tumor metabolism with 2-deoxyglucose in patients with castrate-resistant prostate cancer and advanced malignancies

Autor: Eileen White, Murugesan Gounder, Robert S. DiPaola, Hongxia Lin, Simantini Eddy, Susan Goodin, Kevin Bray, M. N. Stein, Chandrika Jeyamohan, Dmitri Dvorzhinski

Publikováno v: The Prostate. 70:1388-1394

A profound difference between cancer and normal tissues is the preferential utilization of glycolysis by cancer cells. To translate this paradigm in the clinic, we completed a phase I study of 2-deoxyglucose (2DG), and assessed 2DG uptake with fluoro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c5b7d4dc131dd7a909e0da298c30b07
https://doi.org/10.1002/pros.21172

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Therapeutic starvation and autophagy in prostate cancer: A new paradigm for targeting metabolism in cancer therapy

Autor: David J. Foran, Cristina M. Karp, Dmitri Dvorzhinski, Anu Thalasila, Eileen White, Kevin Bray, Robin Mathew, M. N. Stein, Robert S. DiPaola, V. P. S. Garikapaty, Donyell Doram, Brian Beaudoin, Michael May

Publikováno v: The Prostate. 68:1743-1752

BACKGROUND Autophagy is a starvation induced cellular process of self-digestion that allows cells to degrade cytoplasmic contents. The understanding of autophagy, as either a mechanism of resistance to therapies that induce metabolic stress, or as a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e4149f88e1ee707698a0c4a47b5c01e
https://doi.org/10.1002/pros.20837

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Nonfluent aphasia after closed head trauma: report of a case

Autor: M. N. Stein, Stephen B Cantrell

Publikováno v: Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons. 57(6)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::547312de37dbd3a29fbc3c5a151435eb
https://pubmed.ncbi.nlm.nih.gov/10368104

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Autophagy Suppresses RIP Kinase-Dependent Necrosis Enabling Survival to mTOR Inhibition

Autor: James J. Chen, Jing Fan, Eileen White, Kevin Bray, M. N. Stein, Alexandria Lau, Anahita Ghavami, Donna D. Zhang, Joshua D. Rabinowitz, Robin Mathew, Jurre J. Kamphorst, Hsin-Yi Chen, Robert S. DiPaola

Publikováno v: PLoS ONE
PLoS ONE, Vol 7, Iss 7, p e41831 (2012)

mTOR inhibitors are used clinically to treat renal cancer but are not curative. Here we show that autophagy is a resistance mechanism of human renal cell carcinoma (RCC) cell lines to mTOR inhibitors. RCC cell lines have high basal autophagy that is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::347618dc0e710ef76521bcec051aa762
https://doi.org/10.1371/journal.pone.0041831

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Is there a therapeutic benefit for patients participating in modern phase I trials?

Autor: M. LaRosiliere, C. M. Thomas, M. N. Stein, Antoinette R. Tan, Eric H. Rubin, Janice M. Mehnert, Biren Saraiya, H. Camisa, P. Kirin, Darlene Gibbon, Elizabeth Poplin, Rebecca A. Moss, J. Aisner, Robert S. DiPaola, Michael P. Kane, Pamela Scott

Publikováno v: Journal of Clinical Oncology. 29:2523-2523

2523 Background: Phase I studies are often criticized for lacking therapeutic intent. We therefore reviewed clinical outcome results from our phase I program, which includes institutional, NCI, and...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4d09bcba7d706c05ffcce61d61db5b58
https://doi.org/10.1200/jco.2011.29.15_suppl.2523

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Phase II study of AT-101 to abrogate Bcl-2-mediated resistance to androgen-deprivation therapy (ADT) in patients (pts) with newly diagnosed androgen-dependent metastatic prostate cancer (ADMPC)

Autor: Maha Hussain, Chandrika Jeyamohan, Greg Wilding, Simantini Eddy, M. N. Stein, Walter M. Stadler, I. Khan, Glenn Liu, Robert S. DiPaola, Edwin M. Posadas

Publikováno v: Journal of Clinical Oncology. 29:137-137

137 Background: Preclinical studies demonstrate that Bcl-2 is over-expressed in most pts with prostate cancer, causes drug resistance to ADT, and that modulation of Bcl-2 improves sensitivity of tumor cells. We are conducting a phase II study for men

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ed703790e4cb5dfded7392c8ee7f4b58
https://doi.org/10.1200/jco.2011.29.7_suppl.137

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