Zobrazeno 1 - 10
of 438
pro vyhledávání: '"M. N. Stein"'
Autor:
Hongxia Lin, Ah-Ng Tony Kong, Murugesan Gounder, M. N. Stein, Joseph R. Bertino, Robert S. DiPaola
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 66:371-375
R-(-)-gossypol acetic acid (AT-101), a natural BH3 mimetic, is investigated in a Phase I/II clinical trial for the treatment of advanced solid tumor malignancies. Gossypol undergoes rapid degradation in solution phase, which causes major technical di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c657241aa1c6724725ac73ce480c64b
https://doi.org/10.1016/j.jpba.2012.03.029
https://doi.org/10.1016/j.jpba.2012.03.029
Autor:
Ahamed Saleem, Eileen White, Urmila Santanam, Dmitri Dvorzhinski, Kevin Bray, M. N. Stein, Robert S. DiPaola, Robin Mathew
Publikováno v:
The Prostate. 72:1374-1381
PURPOSE Targeting multiple anti-apoptotic proteins is now possible with the small molecule BH3 domain mimetics such as ABT-737. Given recent studies demonstrating that autophagy is a resistance mechanism to multiple therapeutic agents in the setting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a60d56f289853d12b1350ea78b621210
https://doi.org/10.1002/pros.22487
https://doi.org/10.1002/pros.22487
Autor:
Murugesan Gounder, Susan Goodin, Ah-Ng Tony Kong, Robert S. DiPaola, Joseph R. Bertino, M. N. Stein, Hongxia Lin
Publikováno v:
Biomedical Chromatography. 26:650-654
2-Deoxyglucose (2-DG), an analog of glucose, is widely used to interfere with glycolysis in tumor cells and studied as a therapeutic approach in clinical trials. To evaluate the pharmacokinetics of 2-DG, we describe the development and validation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99fbe75f47487f032c4e22c4c362d9f4
https://doi.org/10.1002/bmc.1710
https://doi.org/10.1002/bmc.1710
Autor:
Eileen White, Murugesan Gounder, Robert S. DiPaola, Hongxia Lin, Simantini Eddy, Susan Goodin, Kevin Bray, M. N. Stein, Chandrika Jeyamohan, Dmitri Dvorzhinski
Publikováno v:
The Prostate. 70:1388-1394
A profound difference between cancer and normal tissues is the preferential utilization of glycolysis by cancer cells. To translate this paradigm in the clinic, we completed a phase I study of 2-deoxyglucose (2DG), and assessed 2DG uptake with fluoro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c5b7d4dc131dd7a909e0da298c30b07
https://doi.org/10.1002/pros.21172
https://doi.org/10.1002/pros.21172
Autor:
David J. Foran, Cristina M. Karp, Dmitri Dvorzhinski, Anu Thalasila, Eileen White, Kevin Bray, Robin Mathew, M. N. Stein, Robert S. DiPaola, V. P. S. Garikapaty, Donyell Doram, Brian Beaudoin, Michael May
Publikováno v:
The Prostate. 68:1743-1752
BACKGROUND Autophagy is a starvation induced cellular process of self-digestion that allows cells to degrade cytoplasmic contents. The understanding of autophagy, as either a mechanism of resistance to therapies that induce metabolic stress, or as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e4149f88e1ee707698a0c4a47b5c01e
https://doi.org/10.1002/pros.20837
https://doi.org/10.1002/pros.20837
Autor:
Katz, Dana1,2 (AUTHOR) dana.katz@ppk.elte.hu, Horváth, Zsolt2,3 (AUTHOR), Pontes, Halley M.4 (AUTHOR), Koncz, Patrik1,2 (AUTHOR), Demetrovics, Zsolt2,3,5 (AUTHOR), Király, Orsolya2,3 (AUTHOR)
Publikováno v:
Journal of Behavioral Addictions. Sep2024, Vol. 13 Issue 3, p716-728. 13p.
Autor:
Jupowicz-Ginalska, Anna1 a.ginalska@uw.edu.pl, Kopecka-Piech, Katarzyna2 katarzyna.kopecka-piech@umcs.pl
Publikováno v:
Observatorio (OBS*). 2024, Vol. 18 Issue 3, p75-95. 21p.
Autor:
M. N. Stein, Stephen B Cantrell
Publikováno v:
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons. 57(6)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::547312de37dbd3a29fbc3c5a151435eb
https://pubmed.ncbi.nlm.nih.gov/10368104
https://pubmed.ncbi.nlm.nih.gov/10368104
Autor:
DURSUN, Asiye1
Publikováno v:
AYNA Clinical Psychology Journal. 2024, Vol. 11 Issue 2, p448-465. 18p.
Autor:
James J. Chen, Jing Fan, Eileen White, Kevin Bray, M. N. Stein, Alexandria Lau, Anahita Ghavami, Donna D. Zhang, Joshua D. Rabinowitz, Robin Mathew, Jurre J. Kamphorst, Hsin-Yi Chen, Robert S. DiPaola
Publikováno v:
PLoS ONE
PLoS ONE, Vol 7, Iss 7, p e41831 (2012)
PLoS ONE, Vol 7, Iss 7, p e41831 (2012)
mTOR inhibitors are used clinically to treat renal cancer but are not curative. Here we show that autophagy is a resistance mechanism of human renal cell carcinoma (RCC) cell lines to mTOR inhibitors. RCC cell lines have high basal autophagy that is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::347618dc0e710ef76521bcec051aa762
https://doi.org/10.1371/journal.pone.0041831
https://doi.org/10.1371/journal.pone.0041831