Zobrazeno 1 - 5
of 5
pro vyhledávání: '"M. N. Arimilli"'
Autor:
M. N. Arimilli, J. P. Shaw, R. Oliyai, Choung U. Kim, K. C. Cundy, A. Mulato, J. Dougherty, N. Bischofberger
Publikováno v:
Antiviral Chemistry and Chemotherapy. 8:557-564
Potentially orally bioavailable prodrugs of the antiretroviral agent 9-[2-(phosphonomethoxy)propyl]adenine (PMPA) were evaluated. Alkyl methyl carbamates were synthesized by alkylation of PMPA with the corresponding alkyl chloromethyl carbonate and N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53e68a6effe6683ad11d9e7d4f958a75
https://doi.org/10.1177/095632029700800610
https://doi.org/10.1177/095632029700800610
Publikováno v:
ChemInform. 24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6229534a9756ecb67cd2e626392766d
https://doi.org/10.1002/chin.199322278
https://doi.org/10.1002/chin.199322278
Publikováno v:
Pharmaceutical research. 16(11)
The chemical, enzymatic, and biological stabilities and physical properties of a series of salicylate and aryl ester prodrugs of the antiviral agent, cyclic HPMPC, were evaluated to support the selection of a lead compound for clinical development.Ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f9d36370ce783346408ef67c9e7a8d84
https://pubmed.ncbi.nlm.nih.gov/10571273
https://pubmed.ncbi.nlm.nih.gov/10571273
Publikováno v:
Pharmaceutical research. 14(12)
A series of prodrugs designed to enhance the oral bioavailability of the antiretroviral agent 9-[(R)-2-(phosphonomethoxy)propyl]adenine (PMPA; 1) have been synthesized, including a bis-(acyloxymethyl) ester 2 and a series of bis-(alkoxycarbonyloxymet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d18324ef72e7fd0f716dad948303bc84
https://pubmed.ncbi.nlm.nih.gov/9453075
https://pubmed.ncbi.nlm.nih.gov/9453075
Autor:
J P, Shaw, M S, Louie, V V, Krishnamurthy, M N, Arimilli, R J, Jones, A M, Bidgood, W A, Lee, K C, Cundy
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 25(3)
The oral bioavailability of PMEA [9-[2-(phosphonomethoxy)ethyl]adenine; adefovir) has been determined in rats from three bisester prodrugs of PMEA: bis-(pivaloyloxymethyl) PMEA (bis-POM PMEA), bis-(phenyl) PMEA, and bis-(o-ethoxyphenyl) PMEA. The pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fe4f5571ab317a5f44834eef50547654
https://pubmed.ncbi.nlm.nih.gov/9172955
https://pubmed.ncbi.nlm.nih.gov/9172955