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Akademický článek

PP 1.7 – 00051 Continuous decline of intact proviral DNA after two decades of antiretroviral therapy

Autor: M. Nühn, J. Symons, K. Bosman, K. Tesselaar, J.A.M. Borghans, T. Huisman, A. Hoepelman, R.J. De Boer, A. Wensing, M. Nijhuis

Publikováno v: Journal of Virus Eradication, Vol 8, Iss , Pp 100112- (2022)

Externí odkaz: https://doaj.org/article/45c21c859cbb481fb6719f70674ab85e

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Akademický článek

Defective proviruses significantly impact viral transcription and immune activation in men and women with HIV-1 subtype C in rural South Africa

Autor: Ninée V. E. J. Buchholtz, Lucas E. Hermans, Chijioke N. Umunnakwe, Marieke M. Nühn, Regina Voss, Emma Need, Neeltje A. Kootstra, Irma Maurer, Dorien C. M. de Jong, Jori Symons, Hugo A. Tempelman, Annemarie M. J. Wensing, Monique Nijhuis

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

IntroductionThe main obstacle to achieving an HIV-1 cure is the proviral reservoir. To promote equity in HIV cure strategies, it is crucial to study the viral reservoir of the predominant HIV-1 subtype C in both women and men. Therefore, we investiga

Externí odkaz: https://doaj.org/article/cb7079436e894078b14b9014db465d08

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Akademický článek

Development of a highly sensitive and specific intact proviral DNA assay for HIV-1 subtype B and C

Autor: N. V. E. J. Buchholtz, M. M. Nühn, T. C. M. de Jong, T. A. T. Stienstra, K. Reddy, T. Ndung’u, Z. M. Ndhlovu, K. Fisher, S. Palmer, A. M. J. Wensing, J. Symons, M. Nijhuis

Publikováno v: Virology Journal, Vol 21, Iss 1, Pp 1-11 (2024)

Abstract Introduction HIV reservoir quantification is essential for evaluation of HIV curative strategies and may provide valuable insights about reservoir dynamics during antiretroviral therapy. The Intact Proviral DNA Assay (IPDA) provides the uniq

Externí odkaz: https://doaj.org/article/fd508a47187644d9a48c0217930de817

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Akademický článek

Longitudinal Characterization of the Mumps-Specific HLA-A2 Restricted T-Cell Response after Mumps Virus Infection

Autor: Josien Lanfermeijer, Marieke M. Nühn, Maarten E. Emmelot, Martien C. M. Poelen, Cécile A. C. M. van Els, José A. M. Borghans, Debbie van Baarle, Patricia Kaaijk, Jelle de Wit

Publikováno v: Vaccines, Vol 9, Iss 12, p 1431 (2021)

Waning of the mumps virus (MuV)-specific humoral response after vaccination has been suggested as a cause for recent mumps outbreaks in vaccinated young adults, although it cannot explain all cases. Moreover, CD8+ T cells may play an important role i

Externí odkaz: https://doaj.org/article/c1b6f70462924d1b8ff7186e8c560174

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Shock and kill within the CNS: A promising HIV eradication approach?

Autor: Marieke M, Nühn, Stephanie B H, Gumbs, Ninée V E J, Buchholtz, Lisanne M, Jannink, Lavina, Gharu, Lot D, de Witte, Annemarie M J, Wensing, Sharon R, Lewin, Monique, Nijhuis, Jori, Symons

Publikováno v: Journal of Leukocyte Biology. 112:1297-1315

The most studied HIV eradication approach is the “shock and kill” strategy, which aims to reactivate the latent reservoir by latency reversing agents (LRAs) and allowing elimination of these cells by immune-mediated clearance or viral cytopathic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f22d7a0919165203d340fae8e780576
https://doi.org/10.1002/jlb.5vmr0122-046rrr

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Autoimmune Encephalitis Resembling Dementia Syndromes

Autor: Agnes van Sonderen, Marcel M. Verbeek, Robin W. van Steenhoven, Frank Jan de Jong, Marco W.J. Schreurs, Marieke M. Nühn, Marleen H. van Coevorden-Hameete, Marienke A.A.M. de Bruijn, Juna M. de Vries, Yvette S Crijnen, Anna E M Bastiaansen, Peter A. E. Sillevis Smitt, Maarten J. Titulaer

Publikováno v: Neurology® Neuroimmunology & Neuroinflammation
article-version (Version of Record) 3
Neurology(R) neuroimmunology & neuroinflammation, 8(5). Lippincott Williams & Wilkins
Neurology: Neuroimmunology & Neuroinflammation, 8
Neurology: Neuroimmunology & Neuroinflammation, 8, 5

ObjectiveAs autoimmune encephalitis (AIE) can resemble neurodegenerative dementia syndromes, and patients do not always present as encephalitis, this study evaluates how frequently AIE mimics dementia and provides red flags for AIE in middle-aged and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e20a8802b59e166a0027bac97b89e92c
https://pubmed.ncbi.nlm.nih.gov/34341093

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