Zobrazeno 1 - 10
of 63
pro vyhledávání: '"M. Myslinski"'
Organic impurity profiling of fentanyl samples associated with recent clandestine laboratory methods
Autor:
Steven G. Toske, Jennifer R. Mitchell, James M. Myslinski, Andrew J. Walz, David B. Guthrie, Elizabeth M. Guest, Charlotte A. Corbett, Emily D. Lockhart
Publikováno v:
Journal of Forensic Sciences.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee0283402882eb73cf26fb1753d2032f
https://doi.org/10.1111/1556-4029.15281
https://doi.org/10.1111/1556-4029.15281
Autor:
Caroline Langley, Sue Y Bae, Jonah Cheung, Scott D. Pegan, J.J. Height, Mark D Winemiller, Vanessa L Funk, Mark A. Guelta, J.R. McGuire, S.M. Bester, James M. Myslinski
Publikováno v:
Chemical Research in Toxicology. 34:804-816
The recent use of organophosphate nerve agents in Syria, Malaysia, Russia, and the United Kingdom has reinforced the potential threat of their intentional release. These agents act through their ability to inhibit human acetylcholinesterase (hAChE; E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93c840e3110b59e82d39762b12fd214e
https://doi.org/10.1021/acs.chemrestox.0c00406
https://doi.org/10.1021/acs.chemrestox.0c00406
Autor:
James M. Myslinski, Christopher M. Timperley, Nicholas J. Cooper, Fu-Lian Hsu, Neil Roughley, Li Kong, Andrew J Walz, Tyler D. P. Goralski, Tim Rose, Michael G. Feasel
Publikováno v:
ACS Med Chem Lett
[Image: see text] Carfentanil is a synthetic opioid significantly more potent than clinically prescribed fentanyl. The primary metabolites of carfentanil, generated from human liver microsomes, were structurally confirmed through chemical synthesis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a80f1787a3271f7f3fe0503bf41ab87f
https://doi.org/10.1021/acsmedchemlett.9b00404
https://doi.org/10.1021/acsmedchemlett.9b00404
Autor:
J.J. Height, Andrew N. Bigley, Leslie R. Mcmahon, James M. Myslinski, Steven P. Harvey, Sue Y. Bae, Frank M. Raushel
Publikováno v:
Enzyme and Microbial Technology. 112:65-71
The wild-type OPAA enzyme has relatively high levels of catalytic activity against several organophosphate G-type nerve agents. A series of mutants containing replacement amino acids at the OPAA Y212, V342, and I215 sites showed several fold enhanced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b19be2c3190aa7fa724576e7354b5634
https://doi.org/10.1016/j.enzmictec.2017.11.001
https://doi.org/10.1016/j.enzmictec.2017.11.001
Autor:
Paul T. Wilder, Kaylin A. Adipietro, David J. Weber, J.J. Height, Nicholas D. Keul, Scott D. Pegan, Vanessa L Funk, S.M. Bester, Zachary A. Wood, Jonah Cheung, James M. Myslinski
Publikováno v:
Protein Science : A Publication of the Protein Society
Serving a critical role in neurotransmission, human acetylcholinesterase (hAChE) is the target of organophosphate nerve agents. Hence, there is an active interest in studying the mechanism of inhibition and recovery of enzymatic activity, which could
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1630ec7f71bf87abe99728917c68d356
https://pubmed.ncbi.nlm.nih.gov/30993792
https://pubmed.ncbi.nlm.nih.gov/30993792
Publikováno v:
International Journal of Drug Policy. 86:102939
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a2beb680f293df295794a2947c0a23c
https://doi.org/10.1016/j.drugpo.2020.102939
https://doi.org/10.1016/j.drugpo.2020.102939
Publikováno v:
L'Encéphale. 34:183-186
Resume Cette etude exploratoire porte sur l’introduction d’un chien d’assistance en maison de retraite et sur son utilisation dans le soutien psychologique de personnes atteintes de pathologies dementielles a des stades evolues. Elle propose la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9dfc09a38cd4b605819ff59b7da723f0
https://doi.org/10.1016/j.encep.2007.01.006
https://doi.org/10.1016/j.encep.2007.01.006
Publikováno v:
NPG Neurologie - Psychiatrie - Gériatrie. 7:39-45
Resume Le vieillissement des sujets psychotiques demeure encore, a l’heure actuelle, un secteur tres peu explore dans le champ de la psychologie clinique. La reflexion qui sous-tend cette etude s’appuie sur notre experience au sein d’un service
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e785b63faf1a9e41234833e54e3c2a73
https://doi.org/10.1016/s1627-4830(07)91448-8
https://doi.org/10.1016/s1627-4830(07)91448-8
Publikováno v:
Pratiques Psychologiques. 13:137-151
Resume Cette etude apprehende les resistances des personnes âgees et de leurs familles concernant la redaction de directives anticipees et la designation d'une personne de confiance. Des entretiens semi-directifs ont ete realises aupres de 20 person
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6bb0a11e9c82f92852b91aa6eb676370
https://doi.org/10.1016/j.prps.2007.02.005
https://doi.org/10.1016/j.prps.2007.02.005
Publikováno v:
L'Encéphale. 32:92-96
Resume Cette etude pilote s’inscrit dans une approche de la pathologie dementielle qui privilegie l’approche familiale en considerant le couple aidant/aide comme entite de la prise en charge. Elle propose la mise en place de 3 soutiens psychologi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0caf829e6b37d8dce6d61bfb9eba1b7d
https://doi.org/10.1016/s0013-7006(06)76141-3
https://doi.org/10.1016/s0013-7006(06)76141-3