Zobrazeno 1 - 10
of 141
pro vyhledávání: '"M. Munck"'
Autor:
Simon J. Cook, Richard Odle, Marc O'Reilly, Brent Graham, Aurelie Courtin, Emma Minihane, Kathryn Balmanno, Harpreet K. Saini, Joanne M. Munck, Andrew M. Kidger
The RAS-regulated RAF-MEK1/2-ERK1/2 signaling pathway is frequently deregulated in cancer due to activating mutations of growth factor receptors, RAS or BRAF. Both RAF and MEK1/2 inhibitors are clinically approved and various ERK1/2 inhibitors (ERKi)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f75a06a552ccae6e14211a5956c6395
https://doi.org/10.1158/1535-7163.c.6542839
https://doi.org/10.1158/1535-7163.c.6542839
Autor:
Simon J. Cook, Richard Odle, Marc O'Reilly, Brent Graham, Aurelie Courtin, Emma Minihane, Kathryn Balmanno, Harpreet K. Saini, Joanne M. Munck, Andrew M. Kidger
Supplementary Tables and Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5109fc882ed9ce4603d93a4796b6f2f3
https://doi.org/10.1158/1535-7163.22520935.v1
https://doi.org/10.1158/1535-7163.22520935.v1
Autor:
Nicola J. Curtin, Graeme C.M. Smith, David R. Newell, Niall M.B. Martin, Pia Thommes, Andrew Slade, Keith Menear, Roger J. Griffin, Liam Cornell, Julia Bardos, Jody Barbeau, Michele Tavecchio, Celine Cano, Caroline J. Richardson, Helen Jenkins, Yan Zhao, Michael A. Batey, Joanne M. Munck
DNA double-strand breaks (DSB) are the most cytotoxic lesions induced by topoisomerase II poisons. Nonhomologous end joining (NHEJ) is a major pathway for DSB repair and requires DNA-dependent protein kinase (DNA-PK) activity. DNA-PK catalytic subuni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33c9f0d0e3e98828130b4f41f16e3e80
https://doi.org/10.1158/1535-7163.c.6535653.v1
https://doi.org/10.1158/1535-7163.c.6535653.v1
Autor:
Nicola G. Wallis, Alison J.-A. Woolford, Nicola E. Wilsher, Neil T. Thompson, Lukas Stanczuk, Alpesh D. Shah, Caroline J. Richardson, Sharna J. Rich, David C. Rees, Michael Reader, Marc O'Reilly, David Norton, Christopher W. Murray, Sandra Muench, Vanessa Martins, John F. Lyons, Justyna Kucia-Tran, Christopher J. Hindley, Tom D. Heightman, Roberta Ferraldeschi, Charlotte East, Aurélie Courtin, Juan Castro, Jessica L. Brothwood, Luke Bevan, Valerio Berdini, Joanne M. Munck
Supplementary tables 1-6 summarise the kinase panel screen data (1) mouse PK parameters (2) and further details of the anti-tumour activity (5) conferred by ASTX029, plus details of cell lines used in this study (3 and 4) and further details of the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45c83a97aa3dd2ed35fbdc9ef36e9bb5
https://doi.org/10.1158/1535-7163.22521489.v1
https://doi.org/10.1158/1535-7163.22521489.v1
Autor:
Gianni Chessari, Nicola G. Wallis, Nicola E. Wilsher, Pamela A. Williams, Neil T. Thompson, Tomoko Smyth, Sharna J. Rich, Joanne M. Munck, Vanessa Martins, John F. Lyons, Christopher N. Johnson, Jong Sook Ahn, Edward J. Lewis, George A. Ward
XIAP antagonism measurements in HEK293-XIAP-Caspase-9 xenografts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cea30a6b0c9a71da2f81b77d7c229ca
https://doi.org/10.1158/1535-7163.22505335
https://doi.org/10.1158/1535-7163.22505335
Autor:
Gianni Chessari, Nicola G. Wallis, Nicola E. Wilsher, Pamela A. Williams, Neil T. Thompson, Tomoko Smyth, Sharna J. Rich, Joanne M. Munck, Vanessa Martins, John F. Lyons, Christopher N. Johnson, Jong Sook Ahn, Edward J. Lewis, George A. Ward
XIAP antagonism in A375 cells in the presence or absence of TNF-α
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::272a919c682891395a5262d9906acd9f
https://doi.org/10.1158/1535-7163.22505338
https://doi.org/10.1158/1535-7163.22505338
Autor:
Gianni Chessari, Nicola G. Wallis, Nicola E. Wilsher, Pamela A. Williams, Neil T. Thompson, Tomoko Smyth, Sharna J. Rich, Joanne M. Munck, Vanessa Martins, John F. Lyons, Christopher N. Johnson, Jong Sook Ahn, Edward J. Lewis, George A. Ward
Preparation of 2-chloro-1-{6-[(4-fluorophenyl)methyl]-5-(hydroxymethyl)-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-b]pyridin-1-yl}ethan-1-one
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b2eeafc320764ac1f08c123c93107d2
https://doi.org/10.1158/1535-7163.22505329.v1
https://doi.org/10.1158/1535-7163.22505329.v1
Autor:
Gianni Chessari, Nicola G. Wallis, Nicola E. Wilsher, Pamela A. Williams, Neil T. Thompson, Tomoko Smyth, Sharna J. Rich, Joanne M. Munck, Vanessa Martins, John F. Lyons, Christopher N. Johnson, Jong Sook Ahn, Edward J. Lewis, George A. Ward
Fold induction in secreted cytokine concentrations in PBMC supernatants after IAP antagonist treatment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e98517451841d4234f3bcbe24f80914
https://doi.org/10.1158/1535-7163.22505323.v1
https://doi.org/10.1158/1535-7163.22505323.v1
Autor:
Nicola G. Wallis, Alison J.-A. Woolford, Nicola E. Wilsher, Neil T. Thompson, Lukas Stanczuk, Alpesh D. Shah, Caroline J. Richardson, Sharna J. Rich, David C. Rees, Michael Reader, Marc O'Reilly, David Norton, Christopher W. Murray, Sandra Muench, Vanessa Martins, John F. Lyons, Justyna Kucia-Tran, Christopher J. Hindley, Tom D. Heightman, Roberta Ferraldeschi, Charlotte East, Aurélie Courtin, Juan Castro, Jessica L. Brothwood, Luke Bevan, Valerio Berdini, Joanne M. Munck
Supplementary figures 1-7 show the effects of AST029 on ERK signalling in RAS-mutant cell lines (1) and tumour xenograft tissue (3), ASTX029 plasma PK linearity (2), ASTX029 activity in a cell line panel showing MAPK mutation status (4) the effects o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::185aef78c19fca4a606a8b2c178f1341
https://doi.org/10.1158/1535-7163.22521498.v1
https://doi.org/10.1158/1535-7163.22521498.v1
Autor:
Gianni Chessari, Nicola G. Wallis, Nicola E. Wilsher, Pamela A. Williams, Neil T. Thompson, Tomoko Smyth, Sharna J. Rich, Joanne M. Munck, Vanessa Martins, John F. Lyons, Christopher N. Johnson, Jong Sook Ahn, Edward J. Lewis, George A. Ward
Because of their roles in the evasion of apoptosis, inhibitor of apoptosis proteins (IAP) are considered attractive targets for anticancer therapy. Antagonists of these proteins have the potential to switch prosurvival signaling pathways in cancer ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a60ea6ce021ef990a70160ade83095bf
https://doi.org/10.1158/1535-7163.c.6538027.v1
https://doi.org/10.1158/1535-7163.c.6538027.v1