Zobrazeno 1 - 10
of 196
pro vyhledávání: '"M. Mulhern"'
Autor:
Taylor A. Covington, Patrick M. Pilz, Ryan M. Mulhern, Soeun Ngoy, Alex Loscalzo, Jing Liu, Sudeshna Fisch, Jana Grune
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 324:L550-L556
The stressed right ventricle (RV) is particularly susceptible to producing and accumulating reactive oxygen species, leading to extracellular matrix deposition and secretion of natriuretic peptides. The role of specific enzymes with antioxidative cap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82d63e49f111cf24cda45798a04a195d
https://doi.org/10.1152/ajplung.00379.2022
https://doi.org/10.1152/ajplung.00379.2022
Autor:
Huamei He, Ryan M. Mulhern, William M. Oldham, Wusheng Xiao, Yi-Dong Lin, Ronglih Liao, Joseph Loscalzo
Publikováno v:
Circulation Research. 131:562-579
Background: L-2-hydroxyglutarate (L2HG) couples mitochondrial and cytoplasmic energy metabolism to support cellular redox homeostasis. Under oxygen-limiting conditions, mammalian cells generate L2HG to counteract the adverse effects of reductive stre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8cac116a9cbf4571e71078000a74ecb
https://doi.org/10.1161/circresaha.122.321227
https://doi.org/10.1161/circresaha.122.321227
Autor:
Beth R. Sheidley, Jennifer Malinowski, Amanda L. Bergner, Louise Bier, David S. Gloss, Weiyi Mu, Maureen M. Mulhern, Emily J. Partack, Annapurna Poduri
Publikováno v:
Epilepsia. 63:375-387
Numerous genetic testing options for individuals with epilepsy have emerged over the past decade without clear guidelines regarding optimal testing strategies. We performed a systematic evidence review (SER) and conducted meta-analyses of the diagnos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50aad8105d193d664fea10730cae9971
https://doi.org/10.1111/epi.17141
https://doi.org/10.1111/epi.17141
Autor:
Laurie Mlinar, Kenneth M. Engstrom, Emily E. Robinson, Mathew M. Mulhern, Elie Chaaya, Robert E. Malick, Brian R. Lowry, Steven R. Davis, Paul E. Kruk, Pasquale Tirino, Michael C. Hillier, Jace L. Fogle, Wenbin Hu, Patrick E. Manning, John M. Westerberg, Roberta Joudioux, Laura A. McKee, Adelia L. Carragher, Nathan D. Ide, Rajarathnam E. Reddy, Greg Erexson, Lisa Cornelio, Carlos A. Orihuela
Publikováno v:
Organic Process Research & Development. 25:2693-2706
Appropriate control of impurities from all sources is critically important during the development of a pharmaceutical product. One class of impurity that has gained considerable attention over the ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36fd4f3b8aec2ca73e1ca0dabeda5acc
https://doi.org/10.1021/acs.oprd.1c00296
https://doi.org/10.1021/acs.oprd.1c00296
Autor:
Su Yu, Lakshmi Bhagavatula, Brian J. Kotecki, Travis B. Dunn, Eric G. Moschetta, Westin H. Morrill, Andrew R. Ickes, Troy Reynolds, James C. Marek, Michael J. Rozema, Alan Christesen, Michael Rasmussen, Mathew M. Mulhern
Publikováno v:
Organic Process Research & Development. 26:949-962
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1c95c118243fbf10b5043dc6f2d85be
https://doi.org/10.1021/acs.oprd.1c00287
https://doi.org/10.1021/acs.oprd.1c00287
Autor:
Yu-Ming Pu, Yi-Yin Ku, Vincent S. Chan, Michael D. Wendt, Timothy A. Grieme, Alan Christesen, Mathew M. Mulhern
Publikováno v:
The Journal of Organic Chemistry. 84:4814-4829
The process development of a new synthetic route leading to an efficient and robust synthetic process for venetoclax (1: the active pharmaceutical ingredient (API) in Venclexta) is described. The redesigned synthesis features a Buchwald-Hartwig amina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39d73ed1e6451b285f5cf09ec6364e62
https://doi.org/10.1021/acs.joc.8b02750
https://doi.org/10.1021/acs.joc.8b02750
Autor:
Andrea Havasi, Zhiyong Wang, Chinaemere Igwebuike, Steven C. Borkan, Erdjan Salih, Ryan M Mulhern, Ramon G. Bonegio
Publikováno v:
Journal of the American Society of Nephrology. 30:50-62
Background Ischemic AKI lacks a urinary marker for early diagnosis and an effective therapy. Differential nucleophosmin (NPM) phosphorylation is a potential early marker of ischemic renal cell injury and a therapeutic target. Methods Differential NPM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c845afeed7ad2fabaf01b9e753e83ffe
https://doi.org/10.1681/asn.2018040401
https://doi.org/10.1681/asn.2018040401
Autor:
Dawn M. Mulhern, Mona C. Charles
Publikováno v:
Ancient Southwestern Mortuary Practices
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99dd78c5e0fb0a43d97400877cfe9405
https://doi.org/10.5876/9781607320131.c002
https://doi.org/10.5876/9781607320131.c002
Autor:
Dawn M. Mulhern
Publikováno v:
Encyclopedia of Global Archaeology ISBN: 9783319517261
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcb34c9c82c4562058ab88d8ba958ecf
https://doi.org/10.1007/978-3-030-30018-0_162
https://doi.org/10.1007/978-3-030-30018-0_162
Publikováno v:
Proceedings of the Nutrition Society. 79
Both obesity and type 2 diabetes mellitus have been associated with excessive free sugar consumption. Increasingly, LCS are used to replace free sugar to reduce the energy density of the diet, whilst maintaining diet palatability. However, while expe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0ea09966e491344e45ca4cba3215bf6
https://doi.org/10.1017/s0029665120003407
https://doi.org/10.1017/s0029665120003407