Zobrazeno 1 - 10
of 25
pro vyhledávání: '"M. Montalto de Mecca"'
Autor:
M. Montalto de Mecca, Silvia Laura Fanelli, C. Rodriguez de Castro, José Alberto Castro, Laura C Bartel, E. G. Díaz
Publikováno v:
Human & Experimental Toxicology. 26:781-788
Nifurtimox (Nfx) and Benznidazole (Bz) are being used for the treatment of the acute phase of Chagas' disease. Recently, they were also considered for use in the indeterminate phase. Both the nitroheterocyclic drugs have serious toxic side effects. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f308fafba0c66fac7c6fe940afb86c6
https://doi.org/10.1177/0960327107084540
https://doi.org/10.1177/0960327107084540
Publikováno v:
Journal of Applied Toxicology. 24:189-195
Nifurtimox (Nfx) is a drug used in the treatment of Chagas' disease, an endemic parasitic disease from Latin American countries. It produces undesirable side-effects in patients, frequently forcing the treatment to be stopped. Its toxic mechanism is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca9b67b0d21cfaaf802eff26bf275ee8
https://doi.org/10.1002/jat.970
https://doi.org/10.1002/jat.970
Autor:
M. Montalto de Mecca, Guzmán López, M.I. Díaz Gómez, J.A. Castro, María Eugenia Maciel, F. Formosa Lemoine, Leandro Néstor Quintans, Gerardo Daniel Castro, M.H. Costantini
Publikováno v:
Toxicology Letters. 259:S152-S153
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9d91c5d8052e025164aed7330b19606
https://doi.org/10.1016/j.toxlet.2016.07.361
https://doi.org/10.1016/j.toxlet.2016.07.361
Several nitrofurans and nitroimidazoles have been widely used in veterinary medicine. Some of these compounds are breast carcinogens in rodents and their mechanism of action is hypothesized to be related to reactive metabolites generated by nitroredu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa91cabfbefe94e40bccb5dea5f20612
https://www.sciencedirect.com/science/article/pii/S0278691508006091
https://www.sciencedirect.com/science/article/pii/S0278691508006091
Publikováno v:
Toxicology letters. 136(1)
Liver microsomal (mic); nuclei (N) and mitochondria (mit) anaerobically nitroreduce Nifurtimox (Nfx) in the presence of NADPH generating system. Simultaneous formation of small amounts of nitrite was observed in microsomes and nuclei but not in mitoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69dbde747e81ac0bd8fd67ebc63fce80
https://pubmed.ncbi.nlm.nih.gov/12368051
https://pubmed.ncbi.nlm.nih.gov/12368051
Publikováno v:
Research communications in molecular pathology and pharmacology. 108(1-2)
Benznidazole (BZ) is a nitroimidazolic chemotherapeutic agent employed against the acute and indeterminate phase of Chagas' disease, a tropical sickness afflicting more than twenty million people in Latin America. BZ has serious toxic side effects fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c35dc0300a1c76a10778c8520f18502e
https://pubmed.ncbi.nlm.nih.gov/11758973
https://pubmed.ncbi.nlm.nih.gov/11758973
Publikováno v:
Acta pharmacologica Sinica. 21(11)
To study the effects of benznidazole (Bz), a drug used in the chemotherapy of the acute and the intermediate phase of Chagas' disease, on the colon of rats.Sprague Dawley male rats received Bz 100 mg/kg ig. After 24 h colons were examined by electron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d969c62311e37fb261d1a41b9d370d38
https://pubmed.ncbi.nlm.nih.gov/11501063
https://pubmed.ncbi.nlm.nih.gov/11501063
Publikováno v:
Medicina. 61(1)
Nifurtimox (Nfx) is a chemotherapeutic agent used in the treatment of acute Chagas' disease. Clinical and experimental studies with this nitroheterocyclic compound evidenced serious undesirable side effects. These were correlated with Nfx nitroreduct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f5339dfce0c4df506ba60dfd1e46cdc7
https://pubmed.ncbi.nlm.nih.gov/11265627
https://pubmed.ncbi.nlm.nih.gov/11265627
Publikováno v:
Journal of Applied Toxicology; May2004, Vol. 24 Issue 3, p189-195, 7p
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