Zobrazeno 1 - 10
of 95
pro vyhledávání: '"M. Mohtai"'
Autor:
David J. Schurman, R. Lane Smith, M Gupta, B. S. Donlon, N I Hutchinson, Prajnan Das, Dennis R. Carter, M Mohtai, Gary H. Gibbons, John P. Cooke
Publikováno v:
Journal of Orthopaedic Research. 13:824-831
This study tested the effects of fluid-induced shear on high density monolayer cultures of adult articular chondrocytes. Fluid-induced shear (1.6 Pa) was applied by cone viscometer to normal human and bovine articular chondrocytes for periods of 24,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f32447947475c085705f9151e2887589
https://doi.org/10.1002/jor.1100130604
https://doi.org/10.1002/jor.1100130604
Publikováno v:
Journal of Endocrinology. 146:279-286
IGF-I is the major anabolic factor for cartilage matrix production. Chondrocytes and cartilage treated with interleukin-1α (IL-1α), and chondrocytes from several models of inflammatory joint disease, exhibit reduced responsiveness to IGF-I. Since t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eb005906c905791f9bdfba50efb9d39
https://doi.org/10.1677/joe.0.1460279
https://doi.org/10.1677/joe.0.1460279
Autor:
R, Lane Smith, M C, Trindade, T, Ikenoue, M, Mohtai, P, Das, D R, Carter, S B, Goodman, D J, Schurman
Publikováno v:
Biorheology. 37(1-2)
The articular cartilage of diarthrodial joints experiences a variety of stresses, strains and pressures that result from normal activities of daily living. In normal cartilage, the extracellular matrix exists as a highly organized composite of specia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e4f6b9610de550e5bdc4fb2c7edafe6c
https://pubmed.ncbi.nlm.nih.gov/10912182
https://pubmed.ncbi.nlm.nih.gov/10912182
Publikováno v:
Calcified tissue international. 63(6)
Mechanical stress is an important regulator of bone metabolism. Fluid shear stress caused by mechanical load in bone tissue has been shown to be important to both the bone structure and function through its effects on osteocytes and osteoblasts. We e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3f6aaf97a08e8327587034680787493
https://pubmed.ncbi.nlm.nih.gov/9817947
https://pubmed.ncbi.nlm.nih.gov/9817947
Autor:
M Mohtai, William J. Maloney, David J. Schurman, K Tsuchiya, R C Olney, Darrell M. Wilson, Robert L. Smith
Publikováno v:
The Journal of clinical endocrinology and metabolism. 81(3)
Osteoarthritis is a disease in which articular cartilage metabolism is altered, leading to cartilage destruction. As insulin-like growth factor-I (IGF-I) is the major anabolic mediator for articular cartilage, and the IGF-binding proteins (IGFBPs) ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3006bb6473465002cc32b38ace769acc
https://pubmed.ncbi.nlm.nih.gov/8772582
https://pubmed.ncbi.nlm.nih.gov/8772582
Autor:
M. K. Gupta, David J. Schurman, Gary H. Gibbons, Robert L. Smith, John P. Cooke, B. S. Donlon, M. Mohtai, B E Ellison
Publikováno v:
Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 14(1)
This study tested the effect of fluid-induced shear on interleukin-6 expression in normal human articular chondrocytes in vitro. As determined by Northern blot analysis, interleukin-6 mRNA expression occurs in chondrocytes from osteoarthritic cartila
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c7273a171f6b8c3df039605f8e2ea51
https://pubmed.ncbi.nlm.nih.gov/8618168
https://pubmed.ncbi.nlm.nih.gov/8618168
Autor:
F M Torti, D J Schurman, N I Hutchinson, R L Smith, M Mohtai, William G. Stetler-Stevenson, G I Goldberg, Y Tsuji
Publikováno v:
The Journal of clinical investigation. 92(1)
We report here that a 92-kD gelatinolytic metalloproteinase is expressed as protein and mRNA in human osteoarthritic cartilage, but not in normal adult articular cartilage. Western immunoblotting demonstrated that the 92-kD gelatinolytic activity cor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce5d4de38be1c5f64bf3cf8533cbf58b
https://pubmed.ncbi.nlm.nih.gov/8325982
https://pubmed.ncbi.nlm.nih.gov/8325982
Publikováno v:
The American journal of pathology. 136(2)
Using a whole-limb graft model in rats, morphologic changes and variations in the expression of Ia antigen on epidermal cells were investigated in the allografted skin during acute rejection. BN right limbs were transplanted to F344 recipients. Skin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::34f2131a4ccfc896a3a4c7deca3f790c
https://pubmed.ncbi.nlm.nih.gov/2154927
https://pubmed.ncbi.nlm.nih.gov/2154927
Publikováno v:
Pediatric Research. 33:S52-S52
Articular chondrocytes create and maintain articular cartilage and their growth and metabolism are tightly regulated. The insulin-like growth factors (IGFs), and hence the IGF binding proteins (IGFBPs), play a significant, but unclear, role in this r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4016f56d20c1443ecf96e66a54107f41
https://doi.org/10.1203/00006450-199305001-00295
https://doi.org/10.1203/00006450-199305001-00295
Publikováno v:
Transplantation proceedings. 21(1 Pt 3)
The effect of the new immunosuppressive agent FK-506 on rat limb allograft was investigated across the BN-to-F344 histocompatibility barrier. A 14-day course of FK-treatment at doses of 1 mg/kg per day or more, begun on the day of operation, signific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5742ff1d26c07417253704a1809f711f
https://pubmed.ncbi.nlm.nih.gov/2468256
https://pubmed.ncbi.nlm.nih.gov/2468256