Interplay of folded domains and the disordered low-complexity domain in mediating hnRNPA1 phase separation

Autor: Amanda Nourse, Kresten Lindorff-Larsen, Tanja Mittag, Erik W. Martin, Nicole M. Milkovic, Matthew J. Cuneo, Christy R. Grace, F. Emil Thomasen

Publikováno v: Nucleic Acids Research
Martin, E W, Thomasen, F E, Milkovic, N M, Cuneo, M J, Grace, C R, Nourse, A, Lindorff-Larsen, K & Mittag, T 2021, ' Interplay of folded domains and the disordered low-complexity domain in mediating hnRNPA1 phase separation ', Nucleic Acids Research, vol. 49, no. 5, pp. 2931-2945 . https://doi.org/10.1093/nar/gkab063

Liquid–liquid phase separation underlies the membrane-less compartmentalization of cells. Intrinsically disordered low-complexity domains (LCDs) often mediate phase separation, but how their phase behavior is modulated by folded domains is incomple

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5c50ca088123450a669203906ead750
http://europepmc.org/articles/PMC7969017

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Determination of Protein Phase Diagrams by Centrifugation

Autor: Tanja Mittag, Nicole M. Milkovic

Publikováno v: Methods in Molecular Biology ISBN: 9781071605233

Liquid-liquid phase separation (LLPS) underlies the formation of biomolecular condensates, i.e., membrane-less compartments in cells that carry out functions related to RNA metabolism, stress adaptation, transport, or signaling. Examples of such biom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d6e5661bdad73bddf3f34108de17920b
https://doi.org/10.1007/978-1-0716-0524-0_35

Regulation of DJ-1 by Glutaredoxin 1 in Vivo: Implications for Parkinson’s Disease

Autor: Amy L. Wilson-Delfosse, Shu G. Chen, Nicole M. Milkovic, John J. Mieyal, Mark A. Wilson, Pierce L. Curran, Kyonghwan Choe, Chen Yao, Ajit Ray, Olga Gorelenkova Miller, Vijayalakshmi Ravindranath, Marcin Golczak, Wenzhang Wang, William M. Johnson, Xiongwei Zhu, Jiusheng Lin

Publikováno v: Biochemistry. 55:4519-4532

Parkinson's disease (PD) is the second most common neurodegenerative disease worldwide, caused by the degeneration of the dopaminergic neurons in the substantia nigra. Mutations in PARK7 (DJ-1) result in early onset autosomal recessive PD, and oxidat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60ddb03c05403e95c7125fa3aa11383f
https://doi.org/10.1021/acs.biochem.5b01132

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.