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Akademický článek

Complex effects of macrolide venturicidins on bacterial F-ATPases likely contribute to their action as antibiotic adjuvants

Autor: Yakov M. Milgrom, Thomas M. Duncan

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)

Abstract Bacterial energy metabolism is now recognized as a critical factor for the efficacy of antibiotics. The F-type ATPase/ATP synthase (FOF1) is a central player in cellular bioenergetics of bacteria and eukaryotes, and its potential as a select

Externí odkaz: https://doaj.org/article/325aea4a214143369a7b5037f57019a2

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Akademický článek

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F-ATP-ase of Escherichia coli membranes: The ubiquitous MgADP-inhibited state and the inhibited state induced by the ε-subunit's C-terminal domain are mutually exclusive

Autor: Thomas M. Duncan, Yakov M. Milgrom

Publikováno v: Biochimica et biophysica acta. Bioenergetics. 1861(7)

ATP synthases are important energy-coupling, rotary motor enzymes in all kingdoms of life. In all F-type ATP synthases, the central rotor of the catalytic F1 complex is composed of the γ subunit and the N-terminal domain (NTD) of the e subunit. In t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2684b952ad219559125f64255193688
https://pubmed.ncbi.nlm.nih.gov/32194063

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Akademický článek

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Akademický článek

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UCSF Protocol for Caries Arrest Using Silver Diamine Fluoride: Rationale, Indications and Consent

Autor: Jeremy A, Horst, Hellene, Ellenikiotis, Peter M, Milgrom

Publikováno v: Journal of the California Dental Association. 44(1)

The Food and Drug Administration recently cleared silver diamine fluoride for reducing tooth sensitivity. Clinical trials document arrest and prevention of dental caries by silver diamine fluoride. This off-label use is now permissible and appropriat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::1dab6e5ef44f5f2bf8b95cb7f9884c85
https://pubmed.ncbi.nlm.nih.gov/27044232

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MgATP-concentration dependence of protection of yeast vacuolar V-ATPase from inactivation by 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole supports a bi-site catalytic mechanism of ATP hydrolysis

Autor: Yakov M. Milgrom, Elena Milgrom

Publikováno v: Biochemical and Biophysical Research Communications. 423:355-359

Catalytic site occupancy of the yeast vacuolar V-ATPase during ATP hydrolysis in the presence of an ATP-regenerating system was probed using sensitivity of the enzyme to inhibition by 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole (NBD-Cl). The results show

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61e72f379c996f2ca73fc5ff81adb40b
https://doi.org/10.1016/j.bbrc.2012.05.129

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Characteristics of protection by MgADP and MgATP of α3β3Γ subcomplex of thermophilic Bacillus PS3 βY341W-mutant F1-ATPase from inhibition by 7-chloro-4-nitrobenz-2-oxa-1,3-diazole support a Bi-site mechanism of catalysis

Autor: Y. M. Milgrom

Publikováno v: Biochemistry (Moscow). 76:1253-1261

MgADP and MgATP binding to catalytic sites of βY341W-α(3)β(3)γ subcomplex of F(1)-ATPase from thermophilic Bacillus PS3 has been assessed using their effect on the enzyme inhibition by 7-chloro-4-nitrobenz-2-oxa-1,3-diazole (NBD-Cl). It was assum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d0225ab6c2f8ac53cfa009b7d3b00a5
https://doi.org/10.1134/s0006297911110071

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The strength of donor-specific antibody is a more reliable predictor of antibody-mediated rejection than flow cytometry crossmatch analysis in desensitized kidney recipients

Autor: Asif Sharfuddin, Zacharie Brahmi, Tim E. Taber, William C. Goggins, Dennis P. Mishler, Nancy G. Higgins, Muhammad S. Yaqub, Martin M. Milgrom, Andrew L. Lobashevsky, Alejandro Diez, Muhammad A. Mujtaba

Publikováno v: Clinical Transplantation. 25:E96-E102

The aim of this study was to evaluate the utility of donor-specific antibodies (DSA) and flow cytometry crossmatch (FCCM) as tools for predicting antibody-mediated rejection (AMR) in desensitized kidney recipients. Sera from 44 patients with DSA at t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e746de2ea60e0b7953eb5b5b14ab0803
https://doi.org/10.1111/j.1399-0012.2010.01341.x

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