Use of Viral Load as a Surrogate Marker in Clinical Studies of Cytomegalovirus in Solid Organ Transplantation: A Systematic Review and Meta-analysis

Autor: Gary Fahle, Robin K. Avery, Debra Birnkrant, Jeffrey C. Murray, Yoshihiko Murata, Mary Singer, Randi Y. Leavitt, Hans H. Hirsch, Lynn Fallon, Francisco Martinez-Murillo, John E. McKinnon, Gavin Cloherty, Randall Lanier, Rekha Abichandani, Philip R. Krause, Sally Mossman, M Michelle Berrey, Wael Saber, Ali Alghamdi, John A. D. Leake, Raymund R. Razonable, Takashi E. Komatsu, Emily A. Blumberg, Mahmood Tazari, Kurt Gunter, Thomas Mertens, Jens D Lundgren, Yoichiro Natori, Sunwen Chou, Kevin Modarress, Jay Erdman, Li Li, Terry Bowlin, Peter W. Hunt, William Cruikshank, Anna Wijatyk, Frank Kuhr, Garrett Nichols, Aimee Hodowanec, Marcie L. Riches, Shahid Husain, Karl S. Peggs, Jules O'Rear, Johann Mols, Filip Josephson, Christopher Lademacher, Paul Baum, Bernhardt Zeiher, Paul D. Griffiths, Susan Barnett, Mark N. Prichard, Michael Boeckh, Roy F. Chemaly, Megan McCutcheon, Thomas Stamminger, Fausto Baldanti, Chalom Sayada, Veronica Miller, Andreas Pikis, Atul Humar, Dimitri Gonzalez, Barbara D. Alexander, Jennifer Brooks, Jeff Roberts, Camille N. Kotton, Hermann Einsele, Tadd Lazarus, David Boutolleau, Deepali Kumar, Sandra Nusinoff Lehrman, Ani Orchanian-Cheff, Howard Mayer, Heather Gillis, Dong Yu, David Murawski, Per Ljungman, Paula Isabelle Lodding, Lesia K. Dropulic

Publikováno v: Clinical Infectious Diseases. 66:617-631

Symptomatic cytomegalovirus (CMV) disease has been the standard endpoint for clinical trials in organ transplant recipients. Viral load may be a more relevant endpoint due to low frequency of disease. We performed a meta-analysis and systematic revie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad9869816a9bd64d42d0d7ab0a61e725
https://doi.org/10.1093/cid/cix793

Treatment of Primary Human Immunodeficiency Virus Type 1 Infection with Potent Antiretroviral Therapy Reduces Frequency of Rapid Progression to AIDS

Autor: Ann C. Collier, Timothy Schacker, Anthony S. Fauci, Theresa Shea, John N. Krieger, Douglas L. Mayers, Scott J. Brodie, M. Michelle Berrey, Robert W. Coombs, Steven G. Self, Tae Wook Chun, Lawrence Corey

Publikováno v: The Journal of Infectious Diseases. 183:1466-1475

Immunologic data supporting immediate antiretroviral therapy in primary human immunodeficiency virus type 1 (HIV-1) infection are emerging; however, clinical benefit has not been demonstrated. The clinical and virologic course of 47 patients who were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b4992cff94950d3359ad56595de5d73d
https://doi.org/10.1086/320189

Phase 1 evaluation of the respiratory syncytial virus-specific monoclonal antibody palivizumab in recipients of hematopoietic stem cell transplants

Autor: James Balsley, Michael Boeckh, Lawrence Corey, M. Michelle Berrey, Stephen W. Crawford, Raleigh A. Bowden

Publikováno v: The Journal of infectious diseases. 184(3)

Intravenous palivizumab (15 mg/kg) was investigated in 2 phase 1 studies among recipients of hematopoietic stem cell transplants (HSCTs). Study 1 included 6 HSCT patients without active respiratory syncytial virus (RSV) infection. Study 2 included 15

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c85454c6d00556401b4991ab16dcc24f
https://pubmed.ncbi.nlm.nih.gov/11443562

Effect of combination antiretroviral therapy on T-cell immunity in acute human immunodeficiency virus type 1 infection

Autor: Yijian Huang, Uma Malhotra, Luwy Musey, Sophe Ap, Timothy W. Schacker, Lawrence Corey, M. Michelle Berrey, Janan Markee, Darin J. Brown, M. Juliana McElrath

Publikováno v: The Journal of infectious diseases. 181(1)

T-cell responses were evaluated prospectively in 41 patients with acute human immunodeficiency virus type 1 (HIV-1) infection (30 untreated and 11 receiving zidovudine, lamivudine, and indinavir) and in 38 uninfected adults. By 6-12 months, treated p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c4a82106c605f72a8b698ec71bb7f42
https://pubmed.ncbi.nlm.nih.gov/10608758

Antiretroviral Therapy in Primary HIV

Autor: M. Michelle Berrey, Lawrence Corey

Publikováno v: Antiviral Chemotherapy 5 ISBN: 9781461371502

Increasingly, evidence is accumulating that combination antiretroviral therapy can markedly prolong the time to development of AIDS-defming opportunistic infections and death. 12 As such, a natural extension of this concept is the use of antiviral th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::df5b754b72f42b058d454dbc8adc5e7a
https://doi.org/10.1007/978-1-4615-4743-3_21