Zobrazeno 1 - 10
of 28
pro vyhledávání: '"M. Medou"'
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 8:1861-1866
We report the synthesis and the anti-HIV activities of new C 2 -symmetrical and achiral N 1 ,N 3 -dibenzyl-2-hydroxy-propane isosteres. Some of them showed significant inhibitory activity with respect to HIV-infected MT4 cells (compound 6a and 7a , I
Publikováno v:
Tetrahedron Letters. 39:4021-4024
Based on the concept of bioisosterism, we report the computer design and the synthesis of original 7-membered α-phenylthio cyclic oxamides with potent anti HIV-1 properties.
Publikováno v:
European Journal of Medicinal Chemistry. 33:445-450
Based on the specific PhePro proteolytic cleavage of the HIV protease, short pseudo-peptides incorporating a 3-pyrrolidinone ring have been synthesized. Their potencies to inhibit HIV-1 in MT4 cell culture have been evaluated and compared to that of
Autor:
Gilles Quéléver, Michel Camplo, Jean-Claude Chermann, Jean-Louis Kraus, Jean Dessolin, Patrick Vlieghe, M. Bouygues, M. Medou
Publikováno v:
Nucleosides and Nucleotides. 17:957-968
As far as linear N-Boc-polyamines conjugates elicited remarkable anti-HIV activity, the synthesis and anti-HIV properties of cyclic N-Boc-polyamines conjugates such as tetraazamacrocycle-nucleoside were studied. These new conjugates include an ester
Publikováno v:
Journal of Heterocyclic Chemistry. 34:829-833
Synthetic approaches of N-α-hydroxyalkyl amides or urea derivatives are described. In particularly, a new 1,4,6-oxadiazocine-2,5,8-trione was obtained by condensation of glyoxylic acid on urea derivatives in acidic catalysis condition.
Autor:
Jean-Louis Kraus, Jean Dessolin, Fabien Zoulim, JC Graciet, Christelle Borel, Nicolas Mourier, Jean-Claude Chermann, C. Trabaud, Michel Camplo, M. Medou, M. Gamberoni, Olivier Hantz, V. Niddam
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:1775-1780
The syntheses, anti-HIV and anti-HBV in vitro evaluations of new thiazolidinone nucleoside analogues are described. Preliminary molecular modeling studies demonstrated that these new analogues conserved the essential elements of the hypothesized biol
Autor:
M. Gamberoni, C. Trabaud, JC Graciet, Michel Camplo, V. Niddam, Jean-Claude Chermann, N. Mourier, Jean Dessolin, Fabien Zoulim, Olivier Hantz, M. Medou, Jean-Louis Kraus, Christelle Borel
Publikováno v:
ChemInform. 27
Publikováno v:
ChemInform. 28
Autor:
Jean-Louis Kraus, Gilles Quéléver, M. Medou, Michel Camplo, M. Bouygues, Jean-Claude Chermann
Publikováno v:
ChemInform. 29
The syntheses consisting of replacement of proline amino acid by a 3-pyrrolidinone ring in Phe-Pro analogues are described. Preliminary anti-HIV studies demonstrated the potential activity of this new class of compounds.
Publikováno v:
ChemInform. 29
Based on the concept of bioisosterism, we report the computer design and the synthesis of original 7-membered α-phenylthio cyclic oxamides with potent anti HIV-1 properties.