Zobrazeno 1 - 10 of 178 pro vyhledávání: '"M. M. Wick"'
1
Attenuation of interleukin 2-induced pulmonary vascular leak syndrome by low doses of oral methotrexate
Autor: S Q, DeJoy, R, Jeyaseelan, L W, Torley, S R, Schow, M M, Wick, S S, Kerwar
Publikováno v: Cancer research. 55(21)
Pulmonary vascular leak induced in mice by interleukin 2 (IL-2) was attenuated by pretreatment with single or multiple doses of oral methotrexate. Methotrexate also attenuated pulmonary vascular leak when either larger doses of IL-2 or when lymphokin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::95ab1c9dbe025e884e2693279e778b23
https://pubmed.ncbi.nlm.nih.gov/7585532
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2
Role of ultraviolet radiation in the induction of melanocytic tumors in hairless mice following 7,12-dimethylbenz(a)anthracene application and ultraviolet irradiation
Autor: Z, Husain, M A, Pathak, T, Flotte, M M, Wick
Publikováno v: Cancer research. 51(18)
We examined the role of UVR (UV radiation) (UVA, 320-400 nm; UVB, 290-320 nm; and the combination of UVA and UVB) as a promoter in the induction of cutaneous melanoma. One hundred and seventy hairless mice (Skh-hr2), 6-8 weeks old, were treated in 8
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::12c788d3d9f2372ea53dde605e7075c1
https://pubmed.ncbi.nlm.nih.gov/1909931
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3
Lipophilic 5'-alkyl phosphate esters of 1-.beta.-D-arabinofuranosylcytosine and its N4-acyl and 2,2'-anhydro-3'-O-acyl derivatives as potential prodrugs
Autor: S.-H. Kim, J. Ross, M. M. Wick, A. Rosowsky
Publikováno v: Journal of Medicinal Chemistry. 25:171-178
Lipophilic 5'-(alkyl phosphate) esters of 1-beta-D-arabinofuranosylcytosine (ara-C) and several N4-acyl and 3'-O-acyl-2,2'-anhydro derivatives of ara-C were synthesized as potential prodrugs of ara-C 5'-monophosphate (ara-CMP). Alkylphosphorylation o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1307dabaf448a9d4e6d3e3865107281
https://doi.org/10.1021/jm00344a016
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4
3,4-Dihydroxybenzylamine: a dopamine analog with enhanced antitumor activity against B16 melanoma
Autor: M M, Wick
Publikováno v: Journal of the National Cancer Institute. 63(6)
3,4-Dihydroxybenzylamine (DHBA), a dopamine analog, was much less toxic than dopamine when tested against the B16 melanoma in vivo and in vitro. Daily doses of 1,000 mg DHBA/kg were better tolerated than doses of 400 mg dopamine/kg. When tested again
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::38b7d58aa4d76ab954a8d8abdd50754f
https://pubmed.ncbi.nlm.nih.gov/292814
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5
Clinical characteristics of early cutaneous melanoma
Autor: M M, Wick, A J, Sober, T B, Fitzpatrick, M C, Mihm, A W, Kopf, W H, Clark, M S, Blois
Publikováno v: Cancer. 45(10)
Clinical characteristics of the primary tumor in 786 patients with superficial spreading melanoma were studied in a prospective sequential series of patients from the Melanoma Clinical Cooperative Group. The most useful features for early diagnosis w
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e3bb470800cc16080314a5d2b738a714
https://pubmed.ncbi.nlm.nih.gov/7379001
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6
Methotrexate analogues-27. Dual inhibition of dihydrofolate reductase and folylpolyglutamate synthetase by methotrexate and aminopterin analogues with a gamma-phosphonate group in the side chain
Autor: A, Rosowsky, R C, Moran, R A, Forsch, M, Radike-Smith, P D, Colman, M M, Wick, J H, Freisheim
Publikováno v: Biochemical pharmacology. 35(19)
gamma-Phosphonate analogues of methotrexate (MTX) and aminopterin (AMT) were synthesized from 4-amino-4-deoxy-N10-methylpteroic acid and 4-amino-4-deoxy-N10-formylpteroic acid, respectively, by reaction with methyl D,L-2-amino-4-phosphonobutyrate fol
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ec0313b160c253b9b4f5616c13703d73
https://pubmed.ncbi.nlm.nih.gov/3768024
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10
A comparison of dihydrofolate reductase activity in intact leukemia cells and squamous cell carcinoma
Autor: G B, FitzGerald, M M, Wick
Publikováno v: Anti-cancer drug design. 4(1)
This report examines the intracellular activity of dihydrofolate reductase using an in situ assay designed to measure enzymatic activity in intact cells. The rate of uptake of folic acid exceeded the rate of in situ dihydrofolate reductase activity s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1269fefddcb7380d003e9b8ef9c11a5f
https://pubmed.ncbi.nlm.nih.gov/2757754
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