[Untitled]

Autor: Peter J. Dempsey, Richard B. Kim, Mirjana Cvetkovic, Christoph Wandel, Martin F. Fromm, Alastair J. J. Wood, A. K. Chaudhary, Grant R. Wilkinson, M. M. Roden, Brenda F. Leake, F. Belas, Dan M. Roden

Publikováno v: Pharmaceutical Research. 16:408-414

Purpose. CYP3A and P-gp both function to reduce the intracellular concentration of drug substrates, one by metabolism and the other by transmembrane efflux. Moreover, it has been serendipitously noted that the two proteins have many common substrates

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cb4b74c337f5d8240199763c2bbee6d7
https://doi.org/10.1023/a:1018877803319

Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein

Autor: R B, Kim, C, Wandel, B, Leake, M, Cvetkovic, M F, Fromm, P J, Dempsey, M M, Roden, F, Belas, A K, Chaudhary, D M, Roden, A J, Wood, G R, Wilkinson

Publikováno v: Pharmaceutical research. 16(3)

CYP3A and P-gp both function to reduce the intracellular concentration of drug substrates, one by metabolism and the other by transmembrane efflux. Moreover, it has been serendipitously noted that the two proteins have many common substrates and inhi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::383b952b116d687f29775f7c2232b3e3
https://pubmed.ncbi.nlm.nih.gov/10213372

Punishment alters the discriminative stimulus effects of midazolam

Autor: T A, Tatham, M M, Roden, J E, Barrett

Publikováno v: Experimental and clinical psychopharmacology. 5(3)

Experiment 1 examined the effects of punishment on the discriminative stimulus (DS) effects of midazolam (M) and pentobarbital (P) in 3 pigeons. Sessions began with a fixed-interval (FI) 3-min schedule of food reinforcement. After 40 min, either sali

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5bf62af25072d71e34f14902e666d0a9
https://pubmed.ncbi.nlm.nih.gov/9260065

A global initiative to deliver precision health in diabetes.

Autor: Cefalu WT; National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA. william.cefalu@nih.gov., Franks PW; Department of Clinical Sciences, Helsingborg Hospital, Lund University, Helsingborg, Sweden.; Harvard School of Public Health, Boston, MA, USA.; Oxford Centre for Diabetes Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Rosenblum ND; Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada.; Research Institute, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.; Institute of Nutrition, Metabolism and Diabetes, Canadian Institutes of Health Research, Toronto, Ontario, Canada., Zaghloul NA; National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA., Florez JC; Department of Medicine, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Program in Metabolism, Broad Institute, Cambridge, MA, USA.; Program in Medical & Population Genetics, Broad Institute, Cambridge, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Giorgino F; Department of Precision and Regenerative Medicine and Ionian Area, University of Bari Aldo Moro, Bari, Italy., Ji L; Department of Endocrinology and Metabolism, Peking University People's Hospital, Beijing, China.; Peking University Diabetes Center, Beijing, China., Ma RCW; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.; Laboratory for Molecular Epidemiology in Diabetes, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China.; Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, China., Mathieu C; Department of Endocrinology, Katholieke Universiteit Leuven, Leuven, Belgium., Misra S; Division of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Ramirez AH; All of Us Research Program, National Institutes of Health, Bethesda, MD, USA., Roden M; Department of Endocrinology and Diabetology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.; Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.; German Center for Diabetes Research (DZD), Partner Düsseldorf, Müchen-Neuberberg, Germany., Scherer PE; Touchstone Diabetes Center, University of Texas Southwestern Medical Center, Dallas, TX, USA., Sheu WH; Institute of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan City, Taiwan., Stehouwer CDA; Department of Chronic Diseases, Leuven University, Leuven, Belgium., Woo M; Banting and Best Diabetes Centre, University of Toronto, Toronto, Ontario, Canada.; Department of Medicine and Immunology, University of Toronto, Toronto, Ontario, Canada.; Department of Medicine, University Health Network, Toronto, Ontario, Canada., Pragnell M; American Diabetes Association, Arlington, VA, USA., Anand SS; Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada.; Department of Medicine, McMaster University, Hamilton, Ontario, Canada., Carnethon M; Department of Preventive Medicine and Medicine (Pulmonary & Critical Care), Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Chambers JC; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.; School of Public Health, Imperial College London, London, UK.; Precision Health Research (PRECISE), Singapore, Singapore., Dennis JM; Department of Clinical and Biomedical Sciences, University of Exeter Medical School, Exeter, UK., Gloyn AL; Department of Pediatrics, Division of Endocrinology, Stanford School of Medicine, Stanford, CA, USA.; Department of Genetics, Stanford School of Medicine, Stanford, CA, USA.; Stanford Diabetes Research Center, Stanford School of Medicine, Stanford, CA, USA., Herder C; Department of Endocrinology and Diabetology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.; Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.; German Center for Diabetes Research (DZD), Partner Düsseldorf, Müchen-Neuberberg, Germany., Holt RIG; Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK., Manuel DG; The Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.; Department of Family Medicine, University of Ottawa, Ottawa, Ontario, Canada.; School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada.; Canada Bruyère Research Institute, Ottawa, Ontario, Canada., Redondo MJ; Division of Pediatric Endocrinology, Texas Children's Hospital, Houston, TX, USA.; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA., Tandon N; Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, India., Tsang JS; Yale Center for Systems and Engineering Immunology, Yale University, New Haven, CT, USA.; Department of Immunobiology, Yale University, New Haven, CT, USA.; Department of Biomedical Engineering, Yale University, New Haven, CT, USA., Udler MS; Department of Medicine, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Program in Metabolism, Broad Institute, Cambridge, MA, USA.; Program in Medical & Population Genetics, Broad Institute, Cambridge, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Rich SS; Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.

Publikováno v: Nature medicine [Nat Med] 2024 Jul; Vol. 30 (7), pp. 1819-1822.

Regional analysis of inflammation and contractile function in reperfused acute myocardial infarction by in vivo ¹⁹ F cardiovascular magnetic resonance in pigs.

Autor: Bönner F; Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty Heinrich Heine University, Moorenstr. 5, 40225, Düsseldorf, Germany. Florian.Boenner@med.uni-duesseldorf.de., Gastl M; Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty Heinrich Heine University, Moorenstr. 5, 40225, Düsseldorf, Germany., Nienhaus F; Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty Heinrich Heine University, Moorenstr. 5, 40225, Düsseldorf, Germany., Rothe M; Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research, Düsseldorf, Germany.; German Center for Diabetes Research, Partner, Düsseldorf, Germany., Jahn A; Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty Heinrich Heine University, Moorenstr. 5, 40225, Düsseldorf, Germany.; Central Animal Research Facility, Heinrich Heine University, Düsseldorf, Germany., Pfeiler S; Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty Heinrich Heine University, Moorenstr. 5, 40225, Düsseldorf, Germany., Gross U; Institute for Cardiac Diagnostics and Therapy (IKDT), Berlin, Germany., Schultheiss HP; Institute for Cardiac Diagnostics and Therapy (IKDT), Berlin, Germany., Ibanez B; Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.; IIS-Fundación Jiménez Díaz Hospital, Madrid, Spain.; CIBERCV, Madrid, Spain., Kozerke S; Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland., Szendroedi J; Division of Endocrinology and Diabetology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany., Roden M; Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research, Düsseldorf, Germany.; German Center for Diabetes Research, Partner, Düsseldorf, Germany.; Division of Endocrinology and Diabetology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany., Westenfeld R; Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty Heinrich Heine University, Moorenstr. 5, 40225, Düsseldorf, Germany., Schrader J; Department of Molecular Cardiology, Heinrich Heine University, Düsseldorf, Germany.; Experimental Cardiovascular Imaging, Department of Molecular Cardiology, Heinrich Heine University, Düsseldorf, Germany., Flögel U; Department of Molecular Cardiology, Heinrich Heine University, Düsseldorf, Germany.; Cardiovascular Research Institute Düsseldorf (CARID), Medical Faculty, Heinrich Heine University, Düsseldorf, Germany., Heusch G; Institute for Pathophysiology, West German Heart and Vascular Center, University of Essen Medical School, Essen, Germany., Kelm M; Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty Heinrich Heine University, Moorenstr. 5, 40225, Düsseldorf, Germany.; Cardiovascular Research Institute Düsseldorf (CARID), Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.

Publikováno v: Basic research in cardiology [Basic Res Cardiol] 2022 Apr 07; Vol. 117 (1), pp. 21. Date of Electronic Publication: 2022 Apr 07.