Zobrazeno 1 - 10
of 51
pro vyhledávání: '"M. M. Monick"'
Autor:
M. M. Monick, Aaron Brent Carter, Dawn M. Flaherty, Gary W. Hunninghake, Pamela K. Robeff, Michael W. Peterson
Publikováno v:
The Journal of Immunology. 166:4713-4720
Exposure of human alveolar macrophages to bacterial LPS results in activation of a number of signal transduction pathways. An early event after the alveolar macrophage comes in contact with LPS is activation of the phosphatidylinositol 3 kinase (PI 3
Publikováno v:
The Journal of Infectious Diseases. 177:1275-1281
The role of "oxidant-sensitive" transcription factors activator protein (AP)-1, nuclear factor (NF)-kappaB, and NF-IL6 in respiratory syncytial virus (RSV)-induced interleukin (IL)-8 gene expression in A549 epithelial cells was evaluated. RSV infecti
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 271:L201-L207
Respiratory syncytial virus (RSV) is an important respiratory pathogen in infants and children. RSV preferentially infects airway epithelium and causes local production of inflammatory cytokines. Ribavirin, the only specific agent available for treat
Publikováno v:
Journal of Infectious Diseases. 174:69-74
Cytomegalovirus (CMV) infection in transplant patients is associated with an increased incidence of gram-negative pneumonia ; the mechanism for this is unknown. Human alveolar macrophages (HAM) are an important part of the response of the lung to gra
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 269:L849-L854
This study was undertaken to examine the surface expression and regulation of CD14 on human alveolar macrophages (HAM). HAM obtained by bronchoalveolar lavage were cultured with or without LPS and with or without fetal bovine serum (FBS) on plastic o
Publikováno v:
Journal of Biological Chemistry. 269:32979-32984
We previously demonstrated that lipopolysaccharide (LPS) increases expression of the prostaglandin H synthase-2 (PGHS-2) gene (Hempel, S.L., Monick, M.M., and Hunninghake, G.W. (1994) J. Clin. Invest. 93, 391-396). In this study, the expression of th
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 267:L33-L38
Interleukin (IL-1) and tumor necrosis factor (TNF) activate human lung fibroblasts through interactions with specific receptors. One effect of this interaction of IL-1 and TNF with fibroblasts is an increased production of the cytokines, IL-6 and IL-
Publikováno v:
The Journal of Immunology. 151:284-290
IL-1 activates human lung fibroblasts via IL-1-specific membrane receptors. The numbers of IL-1 binding sites on fibroblasts are increased after exposure to prostaglandin E2 (PGE2) or IL-1. Increases in binding sites are associated with changes in fu
Autor:
M A Monroy, B G Monks, A C Webb, Lois J. Geist, Gary W. Hunninghake, M. M. Monick, P E Auron, M J Fenton, Mark F. Stinski, J M Dayer
Publikováno v:
Molecular and Cellular Biology. 12:3439-3448
Prointerleukin 1[beta] (IL-1[beta]) is a cytokine that mediates a broad range of biological activities. Genomic sequences that regulate IL-1[beta] transcription include both inducible regulatory elements located more than 2,700 bp upstream of the tra
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 262:L454-L458
Human alveolar macrophages stimulated with the calcium ionophore A23187 selectively release large amounts of leukotriene B4 (LTB4) and (+/-)-5-hydroxy-(6E, 8Z-11Z, 14Z)-eicosatetraenoic acid. To determine whether LTB4 release by human alveolar macrop