Výsledky vyhledávání - "M. M. C. Lai"

Transcription of Subgenomic mRNA of Hepatitis Delta Virus Requires a Modified Hepatitis Delta Antigen That Is Distinct from Antigenomic RNA Synthesis

Autor: M. M. C. Lai, King-Song Jeng, Chung-Hsin Tseng

Publikováno v: Journal of Virology. 82:9409-9416

Hepatitis delta virus (HDV) contains a viroid-like, 1.7-kb circular RNA genome, which replicates via a double-rolling-circle model. However, the exact mechanism involved in HDV genome RNA replication and subgenomic mRNA transcription is still unclear

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a0004627e2dc87d77d217f7be69fe20
https://doi.org/10.1128/jvi.00428-08

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Association of Hepatitis C Virus Replication Complexes with Microtubules and Actin Filaments Is Dependent on the Interaction of NS3 and NS5A

Autor: Chao-Kuen Lai, King-Song Jeng, Keigo Machida, M. M. C. Lai

Publikováno v: Journal of Virology. 82:8838-8848

The hepatitis C virus (HCV) RNA replication complex (RC), which is composed of viral nonstructural (NS) proteins and host cellular proteins, replicates the viral RNA genome in association with intracellular membranes. Two viral NS proteins, NS3 and N

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5c1f456977f4d71850b7f04d0a5e3e7
https://doi.org/10.1128/jvi.00398-08

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Hepatitis delta antigens enhance the ribozyme activities of hepatitis delta virus RNA in vivo

Autor: King-Song Jeng, M. M. C. Lai, P.-Y. Su

Publikováno v: Journal of Virology. 70:4205-4209

The mechanism of regulation for the ribozyme activity of hepatitis delta virus (HDV) RNA in infected cells is unknown. Previously, we developed a direct assay capable of detecting the ribozyme activity of HDV dimer or trimer RNAs in vivo (K.-S. Jeng,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee166ad075eb107f843cbb6299b91d55
https://doi.org/10.1128/jvi.70.7.4205-4209.1996

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A pseudoknot ribozyme structure is active in vivo and required for hepatitis delta virus RNA replication

Autor: King-Song Jeng, M. M. C. Lai, A. Daniel

Publikováno v: Journal of Virology. 70:2403-2410

The ribozymes of hepatitis delta virus (HDV) have so far been studied primarily in vitro. Several structural models for HDV ribozymes based on truncated HDV RNA fragments, which are different from the hammerhead or the hairpin/paperclip ribozyme mode

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a19eac9878c2266293566af085254af2
https://doi.org/10.1128/jvi.70.4.2403-2410.1996

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A 5'-proximal RNA sequence of murine coronavirus as a potential initiation site for genomic-length mRNA transcription

Autor: Xuming Zhang, M. M. C. Lai

Publikováno v: Journal of Virology. 70:705-711

Coronavirus transcription is a discontinuous process, involving interactions between a trans-acting leader and the intergenic transcription initiation sequences. A 9-nucleotide (nt) sequence (UUUAUAAAC), which is located immediately downstream of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9902f967287725a60b726f059a064019
https://doi.org/10.1128/jvi.70.2.705-711.1996

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Differential Subcellular Localization of Hepatitis C Virus Core Gene Products

Autor: Frank R. Masiarz, Soon B. Hwang, Shih-Yen Lo, M. M. C. Lai, Jing-Hsiung Ou

Publikováno v: Virology. 213(2):455-461

The expression of the core gene of two different hepatitis C virus (HCV) isolates was analyzed. In the presence of its downstream E1 envelope protein sequence, two major core protein products with molecular masses of 21 kDa (P21) and 19 kDa (P19) and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30b951bc813b94a61068f9bf19dcd8a9

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Replication of hepatitis delta virus RNA in mice after intramuscular injection of plasmid DNA

Autor: B. Lim, John M. Polo, Sugantha Govindarajan, M. M. C. Lai

Publikováno v: Journal of Virology. 69:5203-5207

To establish a readily manipulable small-animal system for the study of human hepatitis delta virus (HDV) replication in vivo, plasmid DNAs containing head-to-tail cDNA dimers of HDV were inoculated intramuscularly into mice. Genomic-sense HDV RNA wa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dc8fff6715ccf2aff273cf130af2015
https://doi.org/10.1128/jvi.69.8.5203-5207.1995

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Transgenic mice support replication of hepatitis delta virus RNA in multiple tissues, particularly in skeletal muscle

Autor: B. Lim, Sugantha Govindarajan, King-Song Jeng, Florence M. Hofman, John M. Polo, M. M. C. Lai, F. Sangiorgi

Publikováno v: Journal of Virology. 69:4880-4887

Hepatitis delta virus (HDV) is hepatotropic and frequently causes fulminant hepatitis in both human and nonhuman primate hosts. To understand the molecular basis of HDV tissue tropism and the mechanism of pathogenesis, transgenic mice in which replic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be593127702a9a7b663ae9a16321e101
https://doi.org/10.1128/jvi.69.8.4880-4887.1995

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Interactions between the cytoplasmic proteins and the intergenic (promoter) sequence of mouse hepatitis virus RNA: correlation with the amounts of subgenomic mRNA transcribed

Autor: M. M. C. Lai, Xuming Zhang

Publikováno v: Journal of Virology. 69:1637-1644

Previous studies suggested that coronavirus RNA transcription involves interaction between leader RNA and the intergenic (IG) sequences, probably via protein-RNA interactions (X. M. Zhang, C.-L. Liao, and M. M. C. Lai, J. Virol., 68:4738-4746, 1994;

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60d8909ab3f513f417d2629186cb79c0
https://doi.org/10.1128/jvi.69.3.1637-1644.1995

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