Maternal Separation Impairs Cocaine-Induced Behavioural Sensitization in Adolescent Mice.

Autor: Irene Gracia-Rubio, Elena Martinez-Laorden, Maria Moscoso-Castro, M Victoria Milanés, M Luisa Laorden, Olga Valverde

Publikováno v: PLoS ONE, Vol 11, Iss 12, p e0167483 (2016)

Adverse early-life conditions induce persistent disturbances that give rise to negative emotional states. Therefore, early life stress confers increased vulnerability to substance use disorders, mainly during adolescence as the brain is still develop

Externí odkaz: https://doaj.org/article/8e06417e472e41b9b7f75f28c24335fb

Hypothalamic orexin--a neurons are involved in the response of the brain stress system to morphine withdrawal.

Autor: M Luisa Laorden, Szilamér Ferenczi, Bernadett Pintér-Kübler, Laura L González-Martín, M Carmen Lasheras, Krisztina J Kovács, M Victoria Milanés, Cristina Núñez

Publikováno v: PLoS ONE, Vol 7, Iss 5, p e36871 (2012)

Both the hypothalamus-pituitary-adrenal (HPA) axis and the extrahypothalamic brain stress system are key elements of the neural circuitry that regulates the negative states during abstinence from chronic drug exposure. Orexins have recently been hypo

Externí odkaz: https://doaj.org/article/e76dbea33c64431ab8293d7422e85503

Modulation of stress- and cocaine prime-induced reinstatement of conditioned place preference after memory extinction through dopamine D3 receptor

Autor: Francisco José Cárceles-Moreno, Juana M. Hidalgo, Cristina Núñez, Rocío Guerrero-Bautista, Guillermo Molina, Bruno Ribeiro Do Couto, M. Victoria Milanés, M. Luisa Laorden

Publikováno v: DIGITUM. Depósito Digital Institucional de la Universidad de Murcia
instname
DIGITUM: Depósito Digital Institucional de la Universidad de Murcia
Universidad de Murcia

Accumulating evidence indicates that dopamine (DA) D3 receptor (DAD3R) antagonists appear highly promising in attenuating cocaine reward and relapse in preclinical models of addiction. In the present study, we investigated the effects of the selectiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d82e38b94a4416a5d819566b6cfbf3c
http://hdl.handle.net/10201/105602

Corticotropin-releasing factor 1 receptor mediates the activity of the reward system evoked by morphine-induced conditioned place preference

Autor: M. Luisa Laorden, M. Victoria Milanés, M. Carmen Lasheras, Cristina Núñez

Publikováno v: Neuropharmacology. 95:168-180

Different neurotransmitter systems are involved in behavioural and molecular responses to morphine. The brain stress system is activated by acute administration of drugs of abuse, being CRF the main neuropeptide of this circuitry. In this study we ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18ec4208185c5fe914247995a11cd6da
https://doi.org/10.1016/j.neuropharm.2014.12.021

Spironolactone decreases the somatic signs of opiate withdrawal by blocking the mineralocorticoid receptors (MR)

Autor: M. Victoria Milanés, M. Luisa Laorden, Javier Navarro-Zaragoza

Publikováno v: Toxicology. 326:36-43

Pharmacological evidence has accumulated showing that glucocorticoids and glucocorticoid receptor (GR) facilitate several responses to different drugs of abuse. Recent findings have attributed a prominent role to the mineralocorticoid receptor (MR) i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c6e531be6a5d51f94ddf1eb72939abe
https://doi.org/10.1016/j.tox.2014.10.002