Výsledky vyhledávání

Molecular Characterization of the Principal Substrate Binding Site of the Ubiquitous Folding Catalyst Protein Disulfide Isomerase

Autor: Lee J. Byrne, Kirsi E.H. Salo, Richard A. Williamson, Heli I. Alanen, Peter Klappa, Kari I. Kivirikko, Mario M. Lobell, Lloyd W. Ruddock, Annamari Pirneskoski, Robert B. Freedman

Publikováno v: Journal of Biological Chemistry. 279:10374-10381

Disulfide bond formation in the endoplasmic reticulum of eukaryotes is catalyzed by the ubiquitously expressed enzyme protein disulfide isomerase (PDI). The effectiveness of PDI as a catalyst of native disulfide bond formation in folding polypeptides

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc44f88709dacf0f6e78dde4d6cf6c0e
https://doi.org/10.1074/jbc.m312193200

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Cardiovascular effects of a novel potent and highly selective azaindole-based inhibitor of Rho-kinase

Autor: R, Kast, H, Schirok, S, Figueroa-Pérez, J, Mittendorf, M J, Gnoth, H, Apeler, J, Lenz, J K, Franz, A, Knorr, J, Hütter, M, Lobell, K, Zimmermann, K, Münter, K H, Augstein, H, Ehmke, J P, Stasch

Publikováno v: British journal of pharmacology. 152(7)

Rho-kinase (ROCK) has been implicated in the pathophysiology of altered vasoregulation leading to hypertension. Here we describe the pharmacological characterization of a potent, highly selective and orally active ROCK inhibitor, the derivative of a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cb98d66acef5ed7c72f746364835db4e
https://pubmed.ncbi.nlm.nih.gov/17934515

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A conserved arginine plays a role in the catalytic cycle of the protein disulphide isomerases

Autor: André H. Juffer, Mario M. Lobell, Anna Kaisa A.K. Lappi, Kirsi E.H. Salo, Heli I. Alanen, Lloyd W. Ruddock, Marc F. Lensink

Publikováno v: Journal of molecular biology. 335(1)

The p K a values of the CXXC active-site cysteine residues play a critical role in determining the physiological function of the thioredoxin superfamily. To act as an efficient thiol-disulphide oxidant the thiolate state of the N-terminal cysteine mu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0bc5ef1111895b1f360a54e6605a0ca
https://pubmed.ncbi.nlm.nih.gov/14659757

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[19] Ester synthesis via acyl transfer (Transesterification)

Autor: M. Lobell, C. Waldinger, M. Berger, K. Laumen, M. P. Schneider, P. Andersch, R. Seemayer, J. Hermann

Publisher Summary Lipases are probably at present the most widely used biocatalysts in organic synthesis. Many of them are commercially available, they are frequently stable toward elevated temperatures and organic solvents, and they are easy to hand

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f77510464735cbeb832f7fec2e319b60
https://doi.org/10.1016/s0076-6879(97)86021-1

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A randomized phase 2 study of the thrombospondin-mimetic peptide ABT-510 in patients with advanced soft tissue sarcoma (STS)

Autor: George D. Demetri, D. S. Mendelson, Dawn M. Carlson, Evelyn McKeegan, E. K. Rowinsky, Raymond A. Knight, Laurence H. Baker, M. Lobell

Publikováno v: Journal of Clinical Oncology. 23:9013-9013

9013 Background: ABT-510 is a 9-amino acid peptide that mimics the antiangiogenic activity of the naturally occurring protein, thrombospondin-1. In phase 1, ABT-510 was tolerated at doses up to 260...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9f82c6ccb1cc2d47bbc6ed5882f3138b
https://doi.org/10.1200/jco.2005.23.16_suppl.9013

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Molecular correlates of the EGFR signaling pathway in association with SWOG S0218: a phase II study of oral EGFR tyrosine kinase inhibitor OSI-774 (NSC-718781) in patients with malignant pleural mesothelioma (MPM)

Autor: Cathryn Rankin, M. Lobell, L. Garland, Ernest C. Borden, Katherine Scott, Saul E. Rivkin, David R. Gandara, R. Nagle, James N. Atkins, Wolfram E. Samlowski

Publikováno v: Journal of Clinical Oncology. 22:3007-3007

3007 Background: MPM is a tumor that shows high expression of EGFR. We evaluated OSI-774, a novel EGFR tyrosine kinase inhibitor (TKI) in MPM and correlated tumor molecular expression of the EGFR signaling pathway with clinical outcomes. Methods: Che

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::468a12af7c0fa34e7500872d263c9384
https://doi.org/10.1200/jco.2004.22.90140.3007

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Induction of myeloperoxidase deficiency in granulocytes in lead- intoxicated dogs

Autor: KC Caldwell, L Taddeini, RL Woodburn, GL Anderson, M Lobell

Publikováno v: Blood. 53:588-593

Lead interferes with heme synthesis in erythrocytes and has a deleterious effect on red cell membranes. We measured myeloperoxidase (MPO) enzyme activity in the granulocytes of dogs fed increasing quantities of lead. Concurrently, iodination capabili

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1fcace5c55cd978bbd94453ae8cc0d01
https://doi.org/10.1182/blood.v53.4.588.bloodjournal534588

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