Zobrazeno 1 - 10
of 89
pro vyhledávání: '"M. Lisa Manning"'
Autor:
Steffen Grosser, Jürgen Lippoldt, Linda Oswald, Matthias Merkel, Daniel M. Sussman, Frédéric Renner, Pablo Gottheil, Erik W. Morawetz, Thomas Fuhs, Xiaofan Xie, Steve Pawlizak, Anatol W. Fritsch, Benjamin Wolf, Lars-Christian Horn, Susanne Briest, Bahriye Aktas, M. Lisa Manning, Josef A. Käs
Publikováno v:
Physical Review X, Vol 11, Iss 1, p 011033 (2021)
Tissue, cell, and nucleus morphology change during tumor progression. In 2D confluent cell cultures, different tissue states, such as fluid (unjammed) and solid (jammed), are correlated with cell shapes. These results do not have to apply a priori to
Externí odkaz:
https://doaj.org/article/d2bc1c5286d3438697d2a8671f69ec4e
Publikováno v:
Physical Review Research, Vol 2, Iss 2, p 023179 (2020)
Contact changes in packings of sheared hard spheres invariably trigger instabilities and irreversible rearrangements, providing an archetypal scenario for plasticity of disordered media. Here we show that the plasticity of jammed soft spheres at any
Externí odkaz:
https://doaj.org/article/4af091f5223641a5aaff404283399bbd
Publikováno v:
Physical Review X, Vol 6, Iss 2, p 021011 (2016)
Cell motion inside dense tissues governs many biological processes, including embryonic development and cancer metastasis, and recent experiments suggest that these tissues exhibit collective glassy behavior. To make quantitative predictions about gl
Externí odkaz:
https://doaj.org/article/1df71b4996ba459f8d98da4d3351daac
Effect of cellular rearrangement time delays on the rheology of vertex models for confluent tissues.
Autor:
Gonca Erdemci-Tandogan, M Lisa Manning
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 6, p e1009049 (2021)
Large-scale tissue deformation during biological processes such as morphogenesis requires cellular rearrangements. The simplest rearrangement in confluent cellular monolayers involves neighbor exchanges among four cells, called a T1 transition, in an
Externí odkaz:
https://doaj.org/article/6a796455cb694a03ab11774aa000ee18
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 2, p e1006732 (2019)
We seek to characterize the motility of mouse fibroblasts on 2D substrates. Utilizing automated tracking techniques, we find that cell trajectories are super-diffusive, where displacements scale faster than t1/2 in all directions. Two mechanisms have
Externí odkaz:
https://doaj.org/article/9ee93c392e704afaa4d792f1233983f2
Autor:
Megan E Brasch, Giuseppe Passucci, Anushree C Gulvady, Christopher E Turner, M Lisa Manning, James H Henderson
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0211408 (2019)
Cell motility is critical to biological processes from wound healing to cancer metastasis to embryonic development. The involvement of organelles in cell motility is well established, but the role of organelle positional reorganization in cell motili
Externí odkaz:
https://doaj.org/article/7a6d0aee5b9a4e8a9029da4fe5934192
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0209892 (2019)
Although cell shape can reflect the mechanical and biochemical properties of the cell and its environment, quantification of 3D cell shapes within 3D tissues remains difficult, typically requiring digital reconstruction from a stack of 2D images. We
Externí odkaz:
https://doaj.org/article/4cb4cc1ae1ac4f238423484f2abab843
Autor:
M. Lisa Manning
Publikováno v:
Physical Review Letters. 130
Publikováno v:
New Journal of Physics, Vol 23, Iss 9, p 093043 (2021)
In dense biological tissues, cell types performing different roles remain segregated by maintaining sharp interfaces. To better understand the mechanisms for such sharp compartmentalization, we study the effect of an imposed heterotypic tension at th
Externí odkaz:
https://doaj.org/article/ab008941f3fd4864a71316f69c17def7
Publikováno v:
Soft Matter. 18:2168-2175
In development and homeostasis, multi-cellular systems exhibit spatial and temporal heterogeneity in their biochemical and mechanical properties. Nevertheless, it remains unclear how spatiotemporally heterogeneous forces affect the dynamical and mech