Výsledky vyhledávání - "M. Lires-Deán"

Anti-apoptotic effect of transforming growth factor-β1 on human articular chondrocytes: role of protein phosphatase 2A

Autor: Beatriz Caramés, F. Galdo, Berta Cillero-Pastor, María J. López-Armada, M. Lires-Deán, Francisco J. Blanco

Publikováno v: Osteoarthritis and Cartilage. 16:1370-1378

Summary Objective To study whether transforming growth factor-β1 (TGF-β1) is able to protect human chondrocytes from apoptosis and to analyze the role of phosphatases in the possible anti-apoptotic effect of TGF-β1. Methods Cartilage was obtained

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ca929cb44222fe37b0196aef35787b1
https://doi.org/10.1016/j.joca.2008.04.001

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Mitochondrial dysfunction activates cyclooxygenase 2 expression in cultured normal human chondrocytes

Autor: Carlos Vaamonde-García, Berta Cillero-Pastor, María J. López-Armada, Beatriz Caramés, M. Lires-Deán, Francisco J. Blanco

Publikováno v: Arthritis & Rheumatism. 58:2409-2419

Objective Mitochondrial alterations play a key role in the pathogenesis of osteoarthritis (OA). This study evaluated a potential role of mitochondrial respiratory chain (MRC) dysfunction in the inflammatory response of normal human chondrocytes. Meth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfd23a5e328938fd0db235f21ce11ad4
https://doi.org/10.1002/art.23644

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Evidencia de mecanismos inflamatorios en la osteoartritis

Autor: M. Lires-Deán, Beatriz Caramés, Franciso Javier Blanco García, Carlos Vaamonde-García, María J. López-Armada, Berta Cillero-Pastor

Publikováno v: Reumatología Clínica. 3:S23-S27

Clasicamente, la artrosis (OA) no ha sido considerada una artropatia inflamatoria por la escasez de neutrofilos en el liquido sinovial y la ausencia de manifestaciones sistemicas de inflamacion. Ademas, las caracteristicas del cartilago articular (av

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7fb2d0e7b09e23b119739da65b54bd80
https://doi.org/10.1016/s1699-258x(07)73651-3

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Mitochondrial activity is modulated by TNFα and IL-1β in normal human chondrocyte cells

Autor: Miguel A. Martín, Beatriz Caramés, Joaquín Arenas, María J. López-Armada, Berta Cillero-Pastor, M. Lires-Deán, Francisco J. Blanco, Isaac Fuentes-Boquete

Publikováno v: RUC. Repositorio da Universidade da Coruña
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[Abstract] Objective. Pro-inflammatory cytokines play an important role in osteoarthritis (OA). In osteoarthritic cartilage, chondrocytes exhibit an alteration in mitochondrial activity. This study analyzes the effect of tumor necrosis factor-α (TNF

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4f69abf1670cfe3806dd4f55a7756c7

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Cytokines, tumor necrosis factor-α and interleukin-1β, differentially regulate apoptosis in osteoarthritis cultured human chondrocytes

Autor: María J. López-Armada, F. Galdo, Francisco J. Blanco, Beatriz Caramés, Cristina Ruiz-Romero, Berta Cillero-Pastor, M. Lires-Deán

Publikováno v: Osteoarthritis and Cartilage. 14:660-669

This study addresses the effects of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) on cell death in human chondrocytes.Osteoarthritis (OA) human chondrocytes stimulated with Actinomycin-D (ActD) were used as a cellular apopt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::890848d6184ff495cc9afa7c9044d5e9
https://doi.org/10.1016/j.joca.2006.01.005

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Differential effects of tumor necrosis factor-alpha and interleukin-1beta on cell death in human articular chondrocytes

Autor: F. Galdo, Francisco J. Blanco, M. Lires-Deán, María J. López-Armada, Beatriz Caramés, Berta Cillero-Pastor, C. Vaamonde

Publikováno v: Osteoarthritis and cartilage. 16(6)

The death of chondrocytes by apoptosis is characteristic of degenerative joint diseases, such as osteoarthritis (OA). Tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) have been shown to play an important role in the developmen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2033e8eef4838e39a107e77b31703e4
https://pubmed.ncbi.nlm.nih.gov/18054255

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