Zobrazeno 1 - 10
of 281
pro vyhledávání: '"M. Lipkind"'
Publikováno v:
Voprosy statistiki. 29:14-32
The article proposes a theoretical rationale and procedure for constructing new composite indicators that combine the results of quarterly consumer expectations surveys conducted by the Federal State Statistics Service (Rosstat). The information capa
Autor:
Gregory M. Lipkind, Harry A. Fozzard
Publikováno v:
Marine Drugs, Vol 8, Iss 2, Pp 219-234 (2010)
Tetrodotoxin and saxitoxin are small, compact asymmetrical marine toxins that block voltage-gated Na channels with high affinity and specificity. They enter the channel pore’s outer vestibule and bind to multiple residues that control permeation. R
Externí odkaz:
https://doaj.org/article/e1c7b892517f4b1983ad708afb018d2c
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1818(8):1823-1830
The amino terminal domain (NT) of the connexins consists of their first 22–23 amino acids. Site-directed mutagenesis studies have demonstrated that NT amino acids are determinants of gap junction channel properties including unitary conductance, pe
Publikováno v:
Molecular Pharmacology. 79:411-419
Verapamil is a prototypical phenylalkylamine (PAA), and it was the first calcium channel blocker to be used clinically. It tonically blocks L-type channels in the inner pore with micromolar affinity, and its affinity increases at depolarized membrane
Publikováno v:
Zentralblatt für Veterinärmedizin Reihe B. 31:721-728
Summary In the course of ecological studies an influenza A virus of the subtype H1N2 isolated from turkeys in Israel was found to be genetically closely related to avian H1N1 viruses from other parts of the world, and to swine H1N1 viruses isolated r
Autor:
Harry A. Fozzard, Gregory M. Lipkind
Publikováno v:
Marine Drugs, Vol 8, Iss 2, Pp 219-234 (2010)
Marine Drugs
Marine Drugs
Tetrodotoxin and saxitoxin are small, compact asymmetrical marine toxins that block voltage-gated Na channels with high affinity and specificity. They enter the channel pore's outer vestibule and bind to multiple residues that control permeation. Rad
Publikováno v:
Trends in Cardiovascular Medicine. 20:16-21
Class I cardiac antiarrhythmic drugs, for example, lidocaine, mexiletine, flecainide, quinidine, and procainamide, continue to play an important role in the therapy for cardiac arrhythmias because of the presence of use-dependent block. Lidocaine, as
Publikováno v:
International Journal of Peptide and Protein Research. 5:381-397
Theoretical analysis of conformations of methylamides of N-acetyl-L-serine and N-acetyl-L-asparagine was carried out proceeding from a mechanical molecular model. The important role of hydrogen bonds between the side chain and the backbone in stabili
Autor:
E. M. Popov, Gregory M. Lipkind
Publikováno v:
International Journal of Peptide and Protein Research. 5:371-379
A semiempirical method has been suggested for calculating the parameter s of the phenomenological theory of helix-random coil transition proposed by Zimm & Bragg. The s parameters for amino acid residues of leucine and aspartic acid have been determi
Autor:
Siri Atma W. Greeley, Anna Pluzhnikov, Nancy J. Cox, Emma L. Edghill, Julie Støy, Sarah E. Flanagan, Louis H. Philipson, Honggang Ye, Donald F. Steiner, Jennifer E. Below, Andrew T. Hattersley, Veronica Paz, Rebecca B. Lipton, Gregory M. Lipkind, Sian Ellard, Graeme I. Bell, M. Geoffrey Hayes, Ann-Marie Patch
Publikováno v:
Støy, J, Edghill, E L, Flanagan, S E, Ye, H, Paz, V P, Pluzhnikov, A, Below, J E, Hayes, M G, Cox, N J, Lipkind, G M, Lipton, R B, Greeley, S A W, Patch, A-M, Ellard, S, Steiner, D F, Hattersley, A T, Philipson, L H, Bell, G I & Neonatal Diabetes International Collaborative Group 2007, ' Insulin gene mutations as a cause of permanent neonatal diabetes ', Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 38, pp. 15040-4 . https://doi.org/10.1073/pnas.0707291104
We report 10 heterozygous mutations in the human insulin gene in 16 probands with neonatal diabetes. A combination of linkage and a candidate gene approach in a family with four diabetic members led to the identification of the initial INS gene mutat