Zobrazeno 1 - 10
of 296
pro vyhledávání: '"M. Linssen"'
Autor:
Nico A. Jansen, Chelsey Linnenbank, Maarten Schenke, Rob A. Voskuyl, Maria S. Jorge, Georgii Krivoshein, Cor Breukel, Margot M. Linssen, Jill W.C. Claassens, Conny Brouwers, Sandra H. van Heiningen, Anders Heuck, Karin Lykke-Hartmann, Else A. Tolner, Arn M.J.M. van den Maagdenberg
Publikováno v:
Neurobiology of Disease, Vol 202, Iss , Pp 106714- (2024)
The mechanisms of initiation of spreading depolarization (SD) are understudied due to a paucity of disease models with spontaneously occurring events. We here present a novel mouse model of familial hemiplegic migraine type 2 (FHM2), expressing the m
Externí odkaz:
https://doaj.org/article/06ea3f35c9c3417aa35517e998fb1500
Autor:
Pascal R. D. Clephas, Jishnu Malgie, Jeroen Schaap, Stefan Koudstaal, Mireille Emans, Gerard C. M. Linssen, Grytsje A. deBoer, Loek vanHeerebeek, C. Jan Willem Borleffs, Olivier C. Manintveld, Vanessa vanEmpel, Sandra vanWijk, Mieke van denHeuvel, Carlos daFonseca, Kevin Damman, Jan vanRamshorst, Roland vanKimmenade, Arjen R. T. van deVen, René A. Tio, Dennis vanVeghel, Folkert W. Asselbergs, Rudolf A. deBoer, Peter van derMeer, Stephen J. Greene, Hans‐Peter Brunner‐La Rocca, Jasper J. Brugts
Publikováno v:
ESC Heart Failure, Vol 11, Iss 1, Pp 550-559 (2024)
Abstract Aims Current heart failure (HF) guidelines recommend to prescribe four drug classes in patients with HF with reduced ejection fraction (HFrEF). A clear challenge exists to adequately implement guideline‐directed medical therapy (GDMT) rega
Externí odkaz:
https://doaj.org/article/76fc22140ff146f4acc31d2d5d84e800
Autor:
Pascal R. D. Clephas, Sumant P. Radhoe, Gerard C. M. Linssen, Jorina Langerveld, Jacobus Plomp, Jeroen P. P. Smits, Michiel J. Nagelsmit, Hans‐Peter Brunner‐La Rocca, Jasper J. Brugts
Publikováno v:
ESC Heart Failure, Vol 10, Iss 2, Pp 1481-1487 (2023)
Abstract Aims Hyperkalaemia is observed frequently in heart failure (HF) patients and is associated with an impaired prognosis and underuse of mineralocorticoid receptor antagonists (MRAs). However, the effects of serum potassium on prescription of t
Externí odkaz:
https://doaj.org/article/f0f352bda9774d41ba51bcdc28fb7a28
Autor:
Szu-Hsien Sam Wu, Heetak Lee, Réka Szép-Bakonyi, Gabriele Colozza, Ayse Boese, Krista R. Gert, Natalia Hallay, Ji-Hyun Lee, Jihoon Kim, Yi Zhu, Margot M. Linssen, Sandra Pilat-Carotta, Peter Hohenstein, Hans-Christian Theussl, Andrea Pauli, Bon-Kyoung Koo
Publikováno v:
Experimental and Molecular Medicine, Vol 55, Iss 6, Pp 1278-1280 (2023)
Externí odkaz:
https://doaj.org/article/75cac3cdb4234b94a32a89994028e3a5
Autor:
Szu-Hsien Sam Wu, Heetak Lee, Réka Szép-Bakonyi, Gabriele Colozza, Ayse Boese, Krista R. Gert, Natalia Hallay, Ji-Hyun Lee, Jihoon Kim, Yi Zhu, Margot M. Linssen, Sandra Pilat-Carotta, Peter Hohenstein, Hans-Christian Theussl, Andrea Pauli, Bon-Kyoung Koo
Publikováno v:
Experimental and Molecular Medicine, Vol 54, Iss 12, Pp 2188-2199 (2022)
Abstract The generation of conditional alleles using CRISPR technology is still challenging. Here, we introduce a Short Conditional intrON (SCON, 189 bp) that enables the rapid generation of conditional alleles via one-step zygote injection. In this
Externí odkaz:
https://doaj.org/article/5d66e37010904229847351b239d105f2
Autor:
Tineke H. Pinxterhuis, Eline H. Ploumen, Paolo Zocca, Carine J. M. Doggen, Carl E. Schotborgh, Rutger L. Anthonio, Ariel Roguin, Peter W. Danse, Edouard Benit, Adel Aminian, Marc Hartmann, Gerard C. M. Linssen, Clemens von Birgelen
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
ObjectivesWe assessed differences in risk profile and 3-year outcome between patients undergoing percutaneous coronary intervention (PCI) for premature and non-premature coronary artery disease (CAD).BackgroundThe prevalence of CAD increases with age
Externí odkaz:
https://doaj.org/article/5bf936d69ec2414aa17f6ea5ca4f4cc3
Autor:
Sumant P. Radhoe, Pascal R. D. Clephas, Gerard C. M. Linssen, Remko M. Oortman, Frank J. Smeele, Annemarie A. Van Drimmelen, Henk-Jan Schaafsma, Paul H. Westendorp, Hans-Peter Brunner-La Rocca, Jasper J. Brugts
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Aims: Implementation of guideline-recommended pharmacological treatment in heart failure (HF) patients remains challenging. In 2021, the European Heart Failure Association (HFA) published a consensus document in which patient profiles were created ba
Externí odkaz:
https://doaj.org/article/b78ec14a8d904dac9e009b5d0ddec211
Autor:
Eline H. Ploumen, Tineke H. Pinxterhuis, Rosaly A. Buiten, Paolo Zocca, Peter W. Danse, Carl E. Schotborgh, Martijn Scholte, R. Melvyn Tjon Joe Gin, Samer Somi, K. Gert van Houwelingen, Martin G. Stoel, H. A. F. de Man, Marc Hartmann, Gerard C. M. Linssen, Liefke C. van der Heijden, Marlies M. Kok, Carine J. M. Doggen, Clemens von Birgelen
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 22 (2022)
Background In a previous trial, higher 5‐year mortality was observed following treatment with biodegradable polymer Orsiro sirolimus‐eluting stents (SES). We assessed 5‐year safety and efficacy of all‐comers as well as patients with diabetes
Externí odkaz:
https://doaj.org/article/c65b5fc2cce445438d8fbe4edbda6f2f
Autor:
Willemien J Kruik-Kollöffel, Job van der Palen, Carine J M Doggen, Marissa C van Maaren, H Joost Kruik, Edith M Heintjes, Kris L L Movig, Gerard C M Linssen
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0244231 (2020)
BackgroundThis study assessed the association between heart failure (HF) medication (angiotensin-converting-enzyme inhibitors (ACEI)/angiotensin-receptor blockers (ARB), beta-blockers (BB), mineralocorticoid-receptor antagonists (MRA) and diuretics)
Externí odkaz:
https://doaj.org/article/83754b373c934081bd5365b6842c3062
Autor:
Marieke S Velema, Evie J M Linssen, Ad R M M Hermus, Hans J M M Groenewoud, Gert-Jan van der Wilt, Antonius E van Herwaarden, Jacques W M Lenders, Henri J L M Timmers, Jaap Deinum
Publikováno v:
Endocrine Connections, Vol 7, Iss 12, Pp 1308-1314 (2018)
Objective: To develop a prediction model to confirm or exclude primary aldosteronism (PA) in patients with an inconclusive salt loading test (SLT). Context: Diagnosis in patients with a suspicion of PA can be confirmed using an SLT. In case of incon
Externí odkaz:
https://doaj.org/article/5e5782714bb64657b2ab29f6493ab7c6