Zobrazeno 1 - 10
of 666
pro vyhledávání: '"M. Lewinsohn"'
Autor:
Melissa D. Chengalroyen, Carolina Mehaffy, Megan Lucas, Niel Bauer, Mabule L. Raphela, Nurudeen Oketade, Digby F. Warner, Deborah A. Lewinsohn, David M. Lewinsohn, Karen M. Dobos, Valerie Mizrahi
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 8 (2024)
ABSTRACT Riboflavin (vitamin B2) is the precursor of the flavin coenzymes, FAD and FMN, which play a central role in cellular redox metabolism. While humans must obtain riboflavin from dietary sources, certain microbes, including Mycobacterium tuberc
Externí odkaz:
https://doaj.org/article/9e0d64474c2449c7bd3876da27d5decc
Autor:
Corinna A. Kulicke, Gwendolyn M. Swarbrick, Nicole A. Ladd, Meghan Cansler, Megan Null, Aneta Worley, Chance Lemon, Tania Ahmed, Joshua Bennett, Taylor N. Lust, Chelsea M. Heisler, Megan E. Huber, Jason R. Krawic, Laurisa M. Ankley, Savannah K. McBride, Fikadu G. Tafesse, Andrew J. Olive, William H. Hildebrand, Deborah A. Lewinsohn, Erin J. Adams, David M. Lewinsohn, Melanie J. Harriff
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract MR1-restricted T cells have been implicated in microbial infections, sterile inflammation, wound healing and cancer. Similar to other antigen presentation molecules, evidence supports multiple, complementary MR1 antigen presentation pathways
Externí odkaz:
https://doaj.org/article/a188a5d473ac493d8d7f9aa7fe4c7e44
Autor:
Haihong Jin, Nicole A. Ladd, Andrew M. Peev, Gwendolyn M. Swarbrick, Meghan Cansler, Megan Null, Christopher T. Boughter, Curtis McMurtrey, Aaron Nilsen, Karen M. Dobos, William H. Hildebrand, Deborah A. Lewinsohn, Erin J. Adams, David M. Lewinsohn, Melanie J. Harriff
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract MR1-restricted T (MR1T) cells recognize microbial small molecule metabolites presented on the MHC Class I-like molecule MR1 and have been implicated in early effector responses to microbial infection. As a result, there is considerable inter
Externí odkaz:
https://doaj.org/article/2922d25154b844d9be6d978cad284414
Autor:
Erin W. Meermeier, Christina L. Zheng, Jessica G. Tran, Shogo Soma, Aneta H. Worley, David I. Weiss, Robert L. Modlin, Gwendolyn Swarbrick, Elham Karamooz, Sharon Khuzwayo, Emily B. Wong, Marielle C. Gold, David M. Lewinsohn
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
Human lung-resident MAIT cells are distinct from CD8+ T cells. They are polycytotoxic, secrete the directly antimicrobial molecule IL-26, express genes associated with persistence, and selectively express interferon-γ- and IL-12- receptors.
Externí odkaz:
https://doaj.org/article/d3ef35794a73444aa9aa0c8fe8dffb79
Autor:
Andriёtte M. Hiemstra, Candice E. MacDonald, Ilana C. van Rensburg, Kim Stanley, Elizna Maasdorp, Shirley Mc Anda, Susanne Tönsing, Jane Alexandra Shaw, Gerard Tromp, Gian D. van der Spuy, Kevin B. Urdahl, David M. Lewinsohn, Helena Kuivaniemi, Nelita Du Plessis, Stephanus T. Malherbe, Gerhard Walzl
Publikováno v:
BMC Infectious Diseases, Vol 22, Iss 1, Pp 1-22 (2022)
Abstract Background Natural immunity against Mycobacterium tuberculosis exists, and > 90% of those infected remain disease-free. Innate and adaptive immune responses required to mediate such protection against tuberculosis (TB) are, however, poorly u
Externí odkaz:
https://doaj.org/article/51be04ee190543e696b8a5a6d4786f48
Autor:
Erin Morrow, Qijia Liu, Sarah Kiguli, Gwendolyn Swarbrick, Mary Nsereko, Megan D. Null, Meghan Cansler, Harriet Mayanja-Kizza, W. Henry Boom, Phalkun Chheng, Melissa R. Nyendak, David M. Lewinsohn, Deborah A. Lewinsohn, Christina L. Lancioni
Publikováno v:
Pathogens, Vol 12, Iss 11, p 1353 (2023)
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a leading cause of pediatric morbidity and mortality. Young children are at high risk of TB following Mtb exposure, and this vulnerability is secondary to insufficient host immuni
Externí odkaz:
https://doaj.org/article/cebbe528c24541dfa889784b98a9c952
Autor:
Anele Gela, Melissa Murphy, Miguel Rodo, Kate Hadley, Willem A. Hanekom, W.Henry Boom, John L. Johnson, Daniel F. Hoft, Simone A. Joosten, Tom H.M. Ottenhoff, Sara Suliman, D.Branch Moody, David M. Lewinsohn, Mark Hatherill, Chetan Seshadri, Elisa Nemes, Thomas J. Scriba, Libby Briel, Hellen Veldtsman, Nondumiso Khomba, Bernadette Pienaar, Hadn Africa, Marcia Steyn
Publikováno v:
EBioMedicine, Vol 76, Iss , Pp 103839- (2022)
Summary: Background: Non-protein antigen classes can be presented to T cells by near-monomorphic antigen-presenting molecules such as CD1, MR1, and butyrophilin 3A1. Such T cells, referred to as donor unrestricted T (DURT) cells, typically express st
Externí odkaz:
https://doaj.org/article/bd74aa9198634f0bb4c2132383ad064c
Autor:
Ruchi Jain Dey, Bappaditya Dey, Melanie Harriff, Elizabeth T. Canfield, David M. Lewinsohn, William R. Bishai
Publikováno v:
mBio, Vol 13, Iss 1 (2022)
ABSTRACT Mucosa-associated invariant T (MAIT) cells play a critical role in antimicrobial defense. Despite increased understanding of their mycobacterial ligands and the clinical association of MAIT cells with tuberculosis (TB), their function in pro
Externí odkaz:
https://doaj.org/article/18b5ce465c3f49ae873de108be0d9c06
Autor:
Luis Schiesari, Miguel G. Matias, Paulo Inácio Prado, Mathew A. Leibold, Cecile H. Albert, Jennifer G. Howeth, Shawn J. Leroux, Renata Pardini, Tadeu Siqueira, Pedro H.S. Brancalion, Mar Cabeza, Renato Mendes Coutinho, José Alexandre Felizola Diniz-Filho, Bertrand Fournier, Daniel J.G. Lahr, Thomas M. Lewinsohn, Ayana Martins, Carla Morsello, Pedro R. Peres-Neto, Valério D. Pillar, Diego P. Vázquez
Publikováno v:
Perspectives in Ecology and Conservation, Vol 17, Iss 4, Pp 172-181 (2019)
The complexity of ecological systems is a major challenge for practitioners and decision-makers who work to avoid, mitigate and manage environmental change. Here, we illustrate how metaecology – the study of spatial interdependencies among ecologic
Externí odkaz:
https://doaj.org/article/3fcaa17affd6477780fd74f1f510cc00
Autor:
Sharon Khuzwayo, Maphe Mthembu, Erin W. Meermeier, Sanjay M. Prakadan, Samuel W. Kazer, Thierry Bassett, Kennedy Nyamande, Dilshaad Fakey Khan, Priya Maharaj, Mohammed Mitha, Moosa Suleman, Zoey Mhlane, Dirhona Ramjit, Farina Karim, Alex K. Shalek, David M. Lewinsohn, Thumbi Ndung’u, Emily B. Wong
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Mucosal associated invariant T (MAIT) cells are a class of innate-like T cells that utilize a semi-invariant αβ T cell receptor to recognize small molecule ligands produced by bacteria and fungi. Despite growing evidence that immune cells at mucosa
Externí odkaz:
https://doaj.org/article/37081af5c8b343fc8e6d5d47528bed3c