Zobrazeno 1 - 10
of 16
pro vyhledávání: '"M. Leonard Mole"'
Autor:
R. Woodrow Setzer, M. Leonard Mole, Robert J. Kavlock, John M. Rogers, Christopher Lau, M. Frank Copeland
Publikováno v:
Toxicological Sciences. 59:49-58
Biologically based dose-response (BBDR) models comprise one way to incorporate mechanistic information into a dose-response assessment to be used for risk assessments. The chemotherapeutic drug 5-fluorouracil (5-FU) has been used as a prototypic comp
Autor:
Dana L. Shuey, M. Leonard Mole, David H. Ellis, M. Frank Copeland, R. Woodrow Setzer, John M. Rogers, Tina R. Logsdon, Christopher Lau, Jennifer Merriman, Robert J. Kavlock, Annie M. Cameron
Publikováno v:
Toxicological Sciences. 59:37-48
Biologically based dose-response (BBDR) models represent an emerging approach to improving the current practice of human health-risk assessment. The concept of BBDR modeling is to incorporate mechanistic information about a chemical that is relevant
Autor:
John M. Rogers, M. Leonard Mole
Publikováno v:
Teratology. 55:364-372
Exposure of pregnant CD-1 mice to methanol (MeOH) by inhalation on gestation days (gd) 6-15 results in dose-related increases in fetal cleft palate, exencephaly, and skeletal defects. Here, critical periods for the developmental toxicity of MeOH were
Autor:
Mark E. Stanton, Philip J. Bushnell, Kevin M. Crofton, L. Earl Gray, Christopher J. Gordon, M. Leonard Mole, Williams K. Boyes, David B. Peele
Publikováno v:
Fundamental and Applied Toxicology. 28:100-110
Assessment of Offspring Development and Behavior Following Gestational Exposure to Inhaled Methanol in the Rat. Stanton, M. E., Crofton, K. M., Gray, L. E., Gordon, C. J., Boyes, W. K., Mole, M. L., Peele, D. B, and Bushnell, P. J. (1995). Fundam. Ap
Autor:
Georgia L. Rehnberg, M. Leonard Mole, Tammy E. Stoker, Joy F. Hein, Ralph L. Cooper, Jerome M. Goldman, W. Keith McElroy
Publikováno v:
Toxicology. 71:69-81
Two experiments were conducted in which the acute effects of inhaled methanol on serum hormones associated with reproductive function in the male rat were evaluated. In the first experiment, rats exposed to methanol (0, 200, 5000 and 10 000 ppm) for
Autor:
M. Leonard Mole, Neil Chernoff, John M. Rogers, Tina R. Logsdon, Robert J. Kavlock, Brenda D. Barbee, Christine I. Turner
Publikováno v:
Teratology. 47(3)
The developmental toxicity of the alternative motor vehicle fuel methanol was assessed in mice by the inhalation route. Pregnant CD-1 mice were exposed to 1,000, 2,000, 5,000, 7,500, 10,000, or 15,000 ppm methanol for 7 hr/day on days 6–15 of gesta
Publikováno v:
Journal of Pharmaceutical Sciences. 63:1872-1876
Naturally occurring cannabinoids previously impossible to separate and analyze were quantitated on a routine basis using silylation. Relative retention times of many silylated cannabinoids are reported for the first time.
Autor:
M. Leonard Mole, Carlton E. Turner
Publikováno v:
Journal of pharmaceutical sciences. 63(1)
9-trans-Tetrahydrocannabivarin, a mixture of sterols (campesterol, stigmasterol, and β-sitosterol), and the amino acid L-proline were isolated from an Indian variant of Cannabis sativa L. Characterizations were accomplished by the usual spectral met
Publikováno v:
Journal of pharmaceutical sciences. 63(7)
Publikováno v:
Phytochemistry. 14:580-581