Zobrazeno 1 - 10 of 53 pro vyhledávání: '"M. Lennarz"'
1
Analysis of SARS-CoV-2-controlled autophagy reveals spermidine, MK-2206, and niclosamide as putative antiviral therapeutics
Autor: Jan Papies, Victor M. Corman, Jackson Emanuel, Daniela Niemeyer, Katja Weckmann, Frederik Dethloff, Christian Drosten, M. Lennarz, Anja Richter, Patrick Giavalisco, Nils C. Gassen, Marcel A. Müller, Thomas Bajaj, Daniel E. Heinz, Nicolas Heinemann
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses an acute threat to public health and the world economy, especially because no approved specific drugs or vaccines are available. Pharmacological modulation of metabolism-dependent cel
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::242bfc55761d0eafb09f5d7845a97e2f
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2
Hypomorphic mutations in POLR_{3}A$ are a frequent cause of sporadic and recessive spastic ataxia
Autor: Ina Schmitt, Oliver Brüstle, Rajech Sharkia, Kristina Rehbach, Stefan Herms, Jennifer Reichbauer, Feifei Tao, Peter De Jonghe, Susanne Greschus, Garth A. Nicholson, Alfredo Ramirez, Stefanie Heilmann-Heimbach, Ludger Schöls, Michael E. Shy, Thomas Klockgether, Paolo Carloni, Holger Wagner, Dagmar Timmann, Claudia Stendel, Delia Kurzwelly, Marina L. Kennerson, Matthis Synofzik, Patrick F. Chinnery, Wolfgang Maier, Stephan Züchner, Peter Bauer, Angela Pyle, Tim W. Rattay, Michael Peitz, Katrin Amunts, Burcu Atasu, Rüdiger Stirnberg, Holger Hengel, Jonathan Baets, Shawna M. E. Feely, Jürgen Kohlhase, Holger Thiele, M. Lennarz, Janine Altmüller, Ilker Karaca, Katherine D. Mathews, Muhammad Mahanjah, Tobias Lindig, Johanna Jung, Alejandro Giorgetti, Rebecca Schüle, Ebba Lohmann, Marc Sturm, Michael Wolf, Rita Horvath, Thomas Klopstock, Michael A. Gonzalez, Martina Minnerop, Peter Nürnberg, Anne S. Soehn, Sandra Roeske
Publikováno v: Brain
Brain 140(6), 1561-1578 (2017). doi:10.1093/brain/awx095
Despite extensive efforts, half of patients with rare movement disorders such as hereditary spastic paraplegias and cerebellar ataxias remain genetically unexplained, implicating novel genes and unrecognized mutations in known genes. Non-coding DNA v
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e5b4967b5395f39db1a93672e9e798b
https://hdl.handle.net/10067/1426480151162165141
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3
Toll-Like Receptor 2 Gene Polymorphisms Arg677Trp and Arg753Gln in Chronic Obstructive Pulmonary Disease
Autor: Vildan Yenice, Adrian Gillissen, Izabela Tuleta, Stefan Pabst, Georg Nickenig, Christian Grohé, M. Lennarz
Publikováno v: Lung. 187:173-178
Chronic obstructive pulmonary disease (COPD) is a leading cause of death worldwide, with a continually rising mortality rate. As COPD is driven by abnormal pulmonary and systemic inflammation, Toll-like receptors (TLRs) seem to be important. TLRs pla
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4c67933b4ed107a7071596a30f58ca9
https://doi.org/10.1007/s00408-009-9144-8
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4
Kaliumcitrat versus Kaliumchlorid bei essentieller Hypertonie: Wirkung auf hämodynamische, hormonelle und metabolische Parameter
Autor: R. Kolloch, K. O. Stumpe, B. Maus, A. Overlack, M. Ruppert, M. Lennarz
Publikováno v: DMW - Deutsche Medizinische Wochenschrift. 120:631-635
A study was conducted on 25 patients (18 men, seven women; mean age 48 [24-70] years) with essential hypertension (EH) to see whether an increase in potassium supply influences blood pressure as well as metabolic and hormonal parameters, and whether
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8bfa9279c522cef278d850374338ae1f
https://doi.org/10.1055/s-2008-1055388
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5
Investigation of the role of rare TREM2 variants in frontotemporal dementia subtypes
Autor: Manuel Seijo-Martínez, Lutz Frölich, Wolfgang Maier, Eckart Rüther, M. Lennarz, Frank Jessen, Axel Wetter, Cristina Razquin, Mercè Boada, Anja Slotosch, Fermin Moreno, Lluís Tárraga, Alberto Lleó, Elena Lorenzo, Dmitriy Drichel, Maria A. Pastor, Jordi Gascon, Jaume Campdelacreu, Tanja Duenkel, Juan Fortea, Michael Hüll, Marinella Damian, Steffen Wolfsgruber, Isabel Hernández, Stefanie Heilmann, Alfredo Ramirez, Sara Ortega-Cubero, Hojjat Ahmadzadehfar, Begoña Indakoetxea, Jordi Clarimón, Michael T. Heneka, Jens Wiltfang, Ramón Reñé, Holger Jahn, Adolfo López de Munain, Michael Wagner, Pau Pastor, Christian Luckhaus, Klaus Fliessbach, Ana Gorostidi, Raquel Sánchez-Valle, Oliver Peters, Tim Becker, Agustín Ruiz, Mario Riverol, Johannes Kornhuber, Mathias Thelen, Albert Lladó
Publikováno v: Neurobiology of aging 35(11), 2657.e13-2657.e19 (2014). doi:10.1016/j.neurobiolaging.2014.06.018
NEUROBIOLOGY OF AGING
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
Frontotemporal dementia (FTD) is a clinically and genetically heterogeneous disorder. Rare TREM2 variants have been recently identified in families affected by FTD-like phenotype. However, genetic studies of the role of rare TREM2 variants in FTD hav
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9a6e80019e37ef11c65804b388b22f0
https://pubmed.ncbi.nlm.nih.gov/25042114
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7
A stop codon polymorphism of toll-like receptor 5 is associated with a stable course of chronic obstructive lung disease
Autor: M. Lennarz, Christian Grohé, Hans Vetter, Vildan Yenice, Bettina Hecht, Adrian Gillissen, Georg Baumgarten, Pascal Knuefermann, Stefan Pabst
Publikováno v: European Respiratory Review, Vol 15, Iss 101, Pp 177-179 (2006)
The etiology of chronic obstructive lung disease (COPD) is unclear. It is supposed to be the product of an exogenous antigenic stimulus, such as tobacco smoke, and an endogenous genetic susceptibility. Toll-like receptors (TLR) are signal molecules,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77f1c83044dbc6045c5080bfb160c0e8
https://doi.org/10.1183/09059180.00010112
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8
ADAM33 gene polymorphisms in chronic obstructive pulmonary disease
Autor: Georg Nickenig, Dirk Skowasch, C. Pizarro Touron, C Grohé, Stefan Pabst, Adrian Gillissen, Izabela Tuleta, M. Lennarz
Publikováno v: European Journal of Medical Research
European Journal of Medical Research, Vol 14, Iss Suppl 4, Pp 182-186 (2009)
Study objective The pathogenesis of chronic obstructive pulmonary disease (COPD) is characterized by an interaction of environmental influences, particularly cigarette smoking, and genetic determinants. Given the global increase in COPD, research on
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ba2a143bee0806cc3e3778586c2605c
https://pubmed.ncbi.nlm.nih.gov/20156753
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9
Transforming Growth Factor Beta (TGFβ) Gene Polymorphisms in Different Phenotypes of Sarcoidosis
Autor: Georg Nickenig, T. Fränken, I. Beier, Dirk Skowasch, J. Schönau, Christian Grohé, M. Lennarz, Stefan Pabst, Sebastian Stier, Rainer Meyer
Publikováno v: Pneumologie. 64
The aetiology of sarcoidosis is unclear. Single nucleotide polymorphisms (SNPs) in transforming growth factor (TGF)-b2 and -b3 have been reported to be associated with the development of lung fibrosis in patients with sarcoidosis. SNPs in TGF-b2 (rs1
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::45187ddfdb6fec92fb49de5b5c323049
https://doi.org/10.1055/s-0029-1247940
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