Zobrazeno 1 - 10
of 115
pro vyhledávání: '"M. Leisner"'
Autor:
Yi An, Jiwoong Lim, Marta Glavatskikh, Xiaowen Wang, Jacqueline Norris-Drouin, P. Brian Hardy, Tina M. Leisner, Kenneth H. Pearce, Dmitri Kireev
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Chemical probes are an indispensable tool for translating biological discoveries into new therapies, though are increasingly difficult to identify since novel therapeutic targets are often hard-to-drug proteins. We introduce FRASE-based hit-
Externí odkaz:
https://doaj.org/article/92dfd03cf5114759b14fbfa0d6d42945
Autor:
Frances M Bashore, Vittorio L Katis, Yuhong Du, Arunima Sikdar, Dongxue Wang, William J Bradshaw, Karolina A Rygiel, Tina M Leisner, Rod Chalk, Swati Mishra, C Andrew Williams, Opher Gileadi, Paul E Brennan, Jesse C Wiley, Jake Gockley, Gregory A Cary, Gregory W Carter, Jessica E Young, Kenneth H Pearce, Haian Fu, Emory-Sage-SGC TREAT-AD Center, Alison D Axtman
Publikováno v:
PLoS ONE, Vol 19, Iss 2, p e0293548 (2024)
RNA sequencing and genetic data support spleen tyrosine kinase (SYK) and high affinity immunoglobulin epsilon receptor subunit gamma (FCER1G) as putative targets to be modulated for Alzheimer's disease (AD) therapy. FCER1G is a component of Fc recept
Externí odkaz:
https://doaj.org/article/a694cd69ff044329bed258122700d8e8
Autor:
Stephen P. Holly, Nidhi Gera, Putianqi Wang, Alexander Wilson, Ziqiang Guan, Ling Lin, Brian Cooley, Hammodah R. Alfar, Ruchi G. Patil, Raymond Piatt, Tina M. Leisner, Wolfgang Bergmeier, Rinku Majumder, Leslie V. Parise
Publikováno v:
Blood Advances, Vol 3, Iss 22, Pp 3818-3828 (2019)
Abstract: We previously reported the discovery of a novel lipid deacetylase in platelets, arylacetamide deacetylase-like 1 (AADACL1/NCEH1), and that its inhibition impairs agonist-induced platelet aggregation, Rap1 GTP loading, protein kinase C (PKC)
Externí odkaz:
https://doaj.org/article/cfd11219f3594d06852884f8acda0943
Autor:
Alexander H. Chung, Tina M. Leisner, Gabrielle J. Dardis, Marissa M. Bivins, Alana L. Keller, Leslie V. Parise
Publikováno v:
Cancer Cell International, Vol 19, Iss 1, Pp 1-15 (2019)
Abstract Background Patients diagnosed with triple negative breast cancer (TNBC) have limited treatment options and often suffer from resistance and toxicity due to chemotherapy. We previously found that depleting calcium and integrin-binding protein
Externí odkaz:
https://doaj.org/article/64814e89ae9f4883b03e0fd9d402ab0e
Autor:
Elizabeth C. Wayne, Christian Long, Matthew J. Haney, Elena V. Batrakova, Tina M. Leisner, Leslie V. Parise, Alexander V. Kabanov
Publikováno v:
Advanced Science, Vol 6, Iss 21, Pp n/a-n/a (2019)
Abstract Delivery of nucleic acids into solid tumor environments remains a pressing challenge. This study examines the ability of macrophages to horizontally transfer small interfering RNA (siRNA) lipoplexes to cancer cells. Macrophages are a natural
Externí odkaz:
https://doaj.org/article/588c1ca743bb4fdf881e4c3a28d78148
Publikováno v:
Metabolites, Vol 11, Iss 1, p 41 (2021)
The primacy of lipids as essential components of cellular membranes is conserved across taxonomic domains. In addition to this crucial role as a semi-permeable barrier, lipids are also increasingly recognized as important signaling molecules with div
Externí odkaz:
https://doaj.org/article/35bd377dd887436e8cf22189820de75c
Autor:
Yuki Goto, Ana C. Puhl, Kenneth H. Pearce, Victoria A Haberman, Xian Chen, Dmitri Kireev, Emerald Hillary Feng, Steven R Fleming, Albert A. Bowers, Hiroaki Suga, Leslie V. Parise, Ling Xie, Tina M. Leisner
Publikováno v:
ACS Med Chem Lett
[Image: see text] Calcium and integrin binding protein 1 (CIB1) is a small, intracellular protein recently implicated in survival and proliferation of triple-negative breast cancer (TNBC). Considering its interactions with PAK1 and downstream signali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63257a2a6544203a3906f569a8c13cdb
https://doi.org/10.1021/acsmedchemlett.1c00438
https://doi.org/10.1021/acsmedchemlett.1c00438
Autor:
Putianqi Wang, Ruchi G. Patil, Ziqiang Guan, Ling Lin, Wolfgang Bergmeier, Brian C. Cooley, Leslie V. Parise, Nidhi Gera, Raymond Piatt, Stephen P. Holly, Tina M. Leisner, Rinku Majumder, Hammodah R. Alfar, Alexander Wilson
Publikováno v:
Blood Advances. 3:3818-3828
We previously reported the discovery of a novel lipid deacetylase in platelets, arylacetamide deacetylase-like 1 (AADACL1/NCEH1), and that its inhibition impairs agonist-induced platelet aggregation, Rap1 GTP loading, protein kinase C (PKC) activatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb73c83ee7be7de4b882ee212c1c0e93
https://doi.org/10.1182/bloodadvances.2018030767
https://doi.org/10.1182/bloodadvances.2018030767
Autor:
Yongzhong Li, Scott M. Leisner
Publikováno v:
Molecular Plant-Microbe Interactions, Vol 15, Iss 10, Pp 1050-1057 (2002)
The Cauliflower mosaic virus (CaMV) gene VI product (P6) is a multifunctional protein essential for viral propagation. It is likely that at least some of these functions require P6 self-association. The work described here was performed to confirm th
Externí odkaz:
https://doaj.org/article/e68b00f5d3534f028b37b4489bbb6086
Autor:
Gabrielle J. Dardis, Alana L. Keller, Alexander H. Chung, Leslie V. Parise, Marissa M. Bivins, Tina M. Leisner
Publikováno v:
Cancer Cell International, Vol 19, Iss 1, Pp 1-15 (2019)
Cancer Cell International
Cancer Cell International
Background Patients diagnosed with triple negative breast cancer (TNBC) have limited treatment options and often suffer from resistance and toxicity due to chemotherapy. We previously found that depleting calcium and integrin-binding protein 1 (CIB1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe016a4b9e7594e862db466aa6a20cf0
http://link.springer.com/article/10.1186/s12935-019-0740-2
http://link.springer.com/article/10.1186/s12935-019-0740-2