Zobrazeno 1 - 10
of 23
pro vyhledávání: '"M. Lee Schmidt"'
Autor:
Dominique Z. Jones, M. Lee Schmidt, Suman Suman, Katharine R. Hobbing, Shirish S. Barve, Leila Gobejishvili, Guy Brock, Carolyn M. Klinge, Shesh N. Rai, Jong Park, Geoffrey J. Clark, Rajesh Agarwal, LaCreis R. Kidd
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-16 (2018)
Abstract Background Dysregulation of microRNA (miRNA) expression is associated with hallmarks of aggressive tumor phenotypes, e.g., enhanced cell growth, proliferation, invasion, and anchorage independent growth in prostate cancer (PCa). Methods Seru
Externí odkaz:
https://doaj.org/article/bfc4991aa79b45b7bd513dceb81c33ea
Autor:
Geoff eClark, Howard eDonninger, Katherine eHobbing, M. Lee Schmidt, Eric eWalters, Laurie eRund, Lawrence eSchook
Publikováno v:
Frontiers in Genetics, Vol 6 (2015)
BRCA1 is a breast and ovarian tumor suppressor. Hereditary mutations in BRCA1 result in a predisposition to breast cancer, and BRCA1 expression is down-regulated in ~30% of sporadic cases. The function of BRCA1 remains poorly understood, but it appea
Externí odkaz:
https://doaj.org/article/ed62eb6045184ed982d15ed19dd97940
Publikováno v:
Cancers
Cancers, Vol 12, Iss 3807, p 3807 (2020)
Volume 12
Issue 12
Cancers, Vol 12, Iss 3807, p 3807 (2020)
Volume 12
Issue 12
Simple Summary The RASSF1A tumor suppressor can serve as a pro-apoptotic effector of the K-RAS oncoprotein. It is frequently inactivated epigenetically in lung cancer, and genetic inactivation of RASSF1A in transgenic mice enhances the ability of mut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0285d0a11a65b6dcd8acd0bbb74dc0a3
http://europepmc.org/articles/PMC7766191
http://europepmc.org/articles/PMC7766191
Autor:
Suman Suman, Geoffrey J. Clark, Katharine R. Hobbing, Guy Brock, Shesh N. Rai, Shirish Barve, Rajesh Agarwal, Leila Gobejishvili, M. Lee Schmidt, Dominique Jones, LaCreis R. Kidd, Carolyn M. Klinge, Jong Y. Park
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-16 (2018)
BMC Cancer
BMC Cancer
Background Dysregulation of microRNA (miRNA) expression is associated with hallmarks of aggressive tumor phenotypes, e.g., enhanced cell growth, proliferation, invasion, and anchorage independent growth in prostate cancer (PCa). Methods Serum-based m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26c3ae4a980b083f77ac28b4fd1d4e25
http://link.springer.com/article/10.1186/s12885-018-4258-0
http://link.springer.com/article/10.1186/s12885-018-4258-0
Autor:
Geoffrey J. Clark, Daniel Brian Nichols, Diego F. Calvisi, Neerja Kaushik-Basu, Howard Donninger, M. Lee Schmidt, Amartya Basu, Payal Arora
Publikováno v:
Hepatology. 65:1462-1477
Hepatitis C virus (HCV) infection is a common risk factor for the development of liver cancer. The molecular mechanisms underlying this effect are only partially understood. Here, we show that the HCV protein, nonstructural protein (NS) 5B, directly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ee136c8bcbe00c002079c4062a4ed1e
https://doi.org/10.1002/hep.29049
https://doi.org/10.1002/hep.29049
Autor:
M. Lee Schmidt, Desmond R. Harrell Stewart, Katherine Hobbing, Geoffrey J. Clark, Howard Donninger
Sir, the recent editorial of our article describing the first animal model for KRAS-driven lung tumors in a RASSF1A-deficient background (1) succinctly and accurately describes our work. I would like to take the opportunity to elaborate and to descri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e15e99c540850e58a8721fb1482da75a
https://europepmc.org/articles/PMC6560612/
https://europepmc.org/articles/PMC6560612/
Autor:
LaCreis R. Kidd, Carolyn M. Klinge, M. Lee Schmidt, Rajesh Agarwal, Suman Suman, Katharine R. Hobbing, Shirish Barve, Shesh N. Rai, Dominique Jones, Guy Brock, Geoffrey J. Clark, Leila Gobejishvili
Publikováno v:
The FASEB Journal. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0406f4da3c92ff4492f7bcd41273696e
https://doi.org/10.1096/fasebj.2018.32.1_supplement.lb677
https://doi.org/10.1096/fasebj.2018.32.1_supplement.lb677
Publikováno v:
Cancer research. 78(10)
Mutant K-RAS has been shown to have both tumor-promoting and -suppressing functions, and growing evidence suggests that the RASSF family of tumor suppressors can act as RAS apoptosis and senescence effectors. It has been hypothesized that inactivatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b9c02440a998c1fef9fb8dd888cb44a
https://pubmed.ncbi.nlm.nih.gov/30997248
https://pubmed.ncbi.nlm.nih.gov/30997248
Publikováno v:
Cancer letters. 400
The Ras genes are the most frequently mutated oncogenes in human cancer. However, Ras biology is quite complex. While Ras promotes tumorigenesis by regulating numerous growth promoting pathways, activated Ras can paradoxically also lead to cell cycle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e60f67dbba46a8bebf2100c48d86c428
https://pubmed.ncbi.nlm.nih.gov/28455242
https://pubmed.ncbi.nlm.nih.gov/28455242
Publikováno v:
Journal of Biological Chemistry. 289:31102-31110
Ras is the most frequently activated oncogene found in human cancer, but its mechanisms of action remain only partially understood. Ras activates multiple signaling pathways to promote transformation. However, Ras can also exhibit a potent ability to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7453b18934170a6110035eae8807b36a
https://doi.org/10.1074/jbc.m114.594283
https://doi.org/10.1074/jbc.m114.594283