Zobrazeno 1 - 10
of 45
pro vyhledávání: '"M. L. Webb"'
Autor:
M. L. Webb
A joyful abc celebration of LGBTQ+ vocabulary for kids of all ages!This alphabet book features bright illustrations and an inclusive message about the beauty of embracing one's truest selfA playdate extravaganza transforms into a celebration of frien
Publikováno v:
The Journal of Immunology. 156:1356-1361
Members of the C-C family of chemotactic cytokines promote chemotaxis and adhesion of leukocytes. In this study, we have identified a murine T cell hybrid that expresses receptors to the chemotactic cytokine monocyte chemotactic protein-1 (MCP-1). Th
Publikováno v:
Life Sciences. 55:1833-1844
Previous work indicated that endothelin (ET) may be involved in the pathogenesis of myocardial ischemia, although the relative importance of the ET receptor subtypes is presently not clear. The purpose of this study was to determine the role of myoca
Autor:
N, Murugesan, Z, Gu, P D, Stein, S, Bisaha, S, Spergel, R, Girotra, V G, Lee, J, Lloyd, R N, Misra, J, Schmidt, A, Mathur, L, Stratton, Y F, Kelly, E, Bird, T, Waldron, E C, Liu, R, Zhang, H, Lee, R, Serafino, B, Abboa-Offei, P, Mathers, M, Giancarli, A A, Seymour, M L, Webb, J T, Hunt
Publikováno v:
Journal of medicinal chemistry. 41(26)
Substitution at the ortho position of N-(3,4-dimethyl-5-isoxazolyl) benzenesulfonamide led to the identification of the biphenylsulfonamides as a novel series of endothelin-A (ETA) selective antagonists. Appropriate substitutions on the pendant pheny
Autor:
F G, Spinale, H H, Holzgrefe, R, Mukherjee, M L, Webb, R B, Hird, M J, Cavallo, J R, Powell, W H, Koster
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 283(3)
Inhibition of the angiotensin-converting enzyme (ACE) in the setting of chronic left ventricular (LV) dysfunction has been demonstrated to have beneficial effects on survival and symptoms. However, whether ACE inhibition has direct effects on myocyte
Publikováno v:
Medicinal research reviews. 17(1)
With the advent of the first generation of both selective and nonselective endothelin antagonists being a relatively recent event, the manifold therapeutic potentials of these compounds are only now being explored clinically. Undoubtedly, numerous cl
Autor:
Patrick B. Thomas, Francis G. Spinale, E. C. K. Liu, Rupak Mukherjee, Latha Hebbar, M. L. Webb
Publikováno v:
The American journal of physiology. 271(6 Pt 2)
Increased plasma concentrations of endothelin have been identified in patients and animals with severe congestive heart failure (CHF). However, whether and to what extent increased endothelin (ET) concentrations influence left ventricular (LV) myocyt
Autor:
M L, Webb, C C, Chao, M, Rizzo, R A, Shapiro, M, Neubauer, E C, Liu, C R, Aversa, R J, Brittain, B, Treiger
Publikováno v:
Molecular pharmacology. 47(4)
Recent evidence suggests a role for endothelin (ET) in contraction of human prostate [J. Urol. 149:495-499 (1993)]. Although both ETA and ETB receptors have been shown to mediate contraction of smooth muscle, the molecular identity of the contractile
Publikováno v:
Pharmacology. 50(1)
Infusion (0.46 mumol/kg/min) of the endothelin (ET)-converting-enzyme inhibitor, phosphoramidon (P), protected function and structure after 30 min renal ischemia in rats more than treatment (5 mumol/kg/min) with the ETA receptor antagonist, BMS-18287
Publikováno v:
The American journal of physiology. 267(4 Pt 1)
Endothelin (ET) has been shown to activate mitogen-activated protein kinase (MAPK). However, it has been unclear which of the ET receptors is coupled to MAPK activation. In the present study, we conducted experiments to determine which ET receptor is