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Lack of immune response to mouse IgG in previously untreated haemophilia A and haemophilia B patients treated with monoclonal antibody purified factor VIII and factor IX preparations

Autor: M. L. Frigo, M. D. Clymer, D. W. Nash, H. M. Davis, G. E. Bergman

Publikováno v: Haemophilia : the official journal of the World Federation of Hemophilia. 3(2)

Immunoaffinity purification of factor VIII and factor IX results in the inclusion of trace quantities (50 ng 100 IU(-1) ) of mouse protein in the final product. It is possible that infusion of extremely low levels of proteins might induce human antim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::843bac0ffb491f874f380ae5e8a7c5b5
https://pubmed.ncbi.nlm.nih.gov/27214718

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