Výsledky vyhledávání - "M. L. Frazier"

Changes in screening behaviors and attitudes toward screening from pre-test genetic counseling to post-disclosure in Lynch syndrome families

Autor: A M, Burton-Chase, S R, Hovick, S K, Peterson, S K, Marani, S W, Vernon, C I, Amos, M L, Frazier, P M, Lynch, E R, Gritz

Publikováno v: Clinical genetics. 83(3)

The purpose of this study was to examine colonoscopy adherence and attitudes toward colorectal cancer (CRC) screening in individuals who underwent Lynch syndrome genetic counseling and testing. We evaluated changes in colonoscopy adherence and CRC sc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1fcfe296a81340cf090f46ecde95901d
https://pubmed.ncbi.nlm.nih.gov/23414081

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Cytotoxic T-Cell Clones Isolated from Ovarian Tumour Infiltrating Lymphocytes Recognize Common Determinants on Non-Ovarian Tumour Clones

Autor: M. S. Pollack, C. G. Ioannides, J. Taylor Wharton, M. L. Frazier, B Fisk, Ralph S. Freedman

Publikováno v: Scandinavian Journal of Immunology. 37:413-424

CTL-TIL lines have been developed from tumour infiltrating lymphocytes (TIL) from the ascites of patients with ovarian carcinoma, and used to investigate whether common tumour antigens are expressed on allogeneic ovarian tumours epithelial tumour lin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2847decd5203782fed237369e2a680ae
https://doi.org/10.1111/j.1365-3083.1993.tb03312.x

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Age-associated risk of cancer among individuals with N-acetyltransferase 2 (NAT2) mutations and mutations in DNA mismatch repair genes

Autor: M L, Frazier, F T, O'Donnell, S, Kong, X, Gu, I, Campos, R, Luthra, P M, Lynch, C I, Amos

Publikováno v: Cancer research. 61(4)

Mutations in N-acetyltransferase 2 (NAT2), a highly polymorphic enzyme involved in the metabolism of xenobiotics and carcinogens, may affect risk for colorectal cancer (CRC), especially among individuals with germ-line mutations in DNA mismatch repai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::39eeaf30a836ae247bdbcebb9d4d9968
https://pubmed.ncbi.nlm.nih.gov/11245417

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Human pancreatic ribonuclease 1: expression and distribution in pancreatic adenocarcinoma

Autor: R, Peracaula, K R, Cleary, J, Lorenzo, R, de Llorens, M L, Frazier

Publikováno v: Cancer. 89(6)

Human pancreatic ribonuclease (RNase 1) is a pancreatic enzyme that is present at high levels in the serum of most patients with pancreatic adenocarcinoma. For this reason, the authors studied its patterns of expression at the single-cell level in pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8a5badcae8ed68801e0e95016224d087
https://pubmed.ncbi.nlm.nih.gov/11002220

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ARHI is the center of allelic deletion on chromosome 1p31 in ovarian and breast cancers

Autor: H, Peng, F, Xu, R, Pershad, K K, Hunt, M L, Frazier, A, Berchuck, J W, Gray, D, Hogg, R C, Bast, Y, Yu

Publikováno v: International journal of cancer. 86(5)

In our previous work, we had characterized ARHI as an imprinted putative tumor-suppressor gene in ovarian and breast cancers. ARHI is expressed in primary breast and ovarian cell lines but largely absent from the corresponding malignant tumors. Moreo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::eb26c59cc0ffdd80cf21fadc97b33c88
https://pubmed.ncbi.nlm.nih.gov/10797292

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Ribonucleases expressed by human pancreatic adenocarcinoma cell lines

Autor: E, Fernández-Salas, R, Peracaula, M L, Frazier, R, de Llorens

Publikováno v: European journal of biochemistry. 267(5)

Human ribonucleases have been considered as a possible tumor marker for pancreatic cancer, and elevated serum levels of ribonuclease activity in patients with pancreatic cancer have been reported by many authors. The reason for this elevation is unkn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::51e5f238d0964b132f6638390060e302
https://pubmed.ncbi.nlm.nih.gov/10691987

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Effects of cyclin D1 polymorphism on age of onset of hereditary nonpolyposis colorectal cancer

Autor: S, Kong, C I, Amos, R, Luthra, P M, Lynch, B, Levin, M L, Frazier

Publikováno v: Cancer research. 60(2)

A common polymorphism in the cyclin D1 gene enhances the gene's alternate splicing. The alternatively spliced product encodes an altered protein that does not contain sequences involved in the turnover of the protein. We found that hereditary nonpoly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::af50549100c24c3e597f698d442f580a
https://pubmed.ncbi.nlm.nih.gov/10667569

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Increased cyclooxygenase-2 expression in human pancreatic carcinomas and cell lines: growth inhibition by nonsteroidal anti-inflammatory drugs

Autor: M A, Molina, M, Sitja-Arnau, M G, Lemoine, M L, Frazier, F A, Sinicrope

Publikováno v: Cancer research. 59(17)

Cyclooxygenase (COX)-2 mRNA and protein expression were found to be frequently elevated in human pancreatic adenocarcinomas and cell lines derived from such tumors. Immunohistochemistry demonstrated cytoplasmic COX-2 expression in 14 of 21 (67%) panc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b7e4d4b6de2c93289a8caca4cc08bf62
https://pubmed.ncbi.nlm.nih.gov/10485483

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Reduction in hMSH2 mRNA levels by premature translation termination: implications for mutation screening in hereditary nonpolyposis colorectal cancer

Autor: X, Lin, J H, Choi, P, Lynch, L, Xi, E, Wu, M L, Frazier

Publikováno v: Digestive diseases and sciences. 44(3)

We have used single-strand conformational polymorphism (SSCP) and heteroduplex analysis to examine DNA from 50 colorectal carcinoma patients coming from families meeting the Amsterdam criteria for hereditary nonpolyposis colorectal cancer (HNPCC) or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2e38488ec7d408f1c26fe9b3963d9236
https://pubmed.ncbi.nlm.nih.gov/10080150

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