Zobrazeno 1 - 10
of 27
pro vyhledávání: '"M. L. Firsov"'
Autor:
A. Yu. Rotov, M. L. Firsov
Publikováno v:
Journal of Evolutionary Biochemistry and Physiology. 58:1675-1686
Abstract Although the experience of optogenetic retinal prosthetics in animal models dates back to more than 16 years, the first results obtained on humans have only been reported in the last year. Over this period, the main challenges of prosthetics
Publikováno v:
Neuroscience and Behavioral Physiology. 51:807-815
The standard model system for studies of inherited retinal pathologies consists of C3H mice, which have a mutation in the Pde6b gene. These animals show impairment to the functioning of rod phosphodiesterase, leading to photoreceptor death and comple
Publikováno v:
Neuroscience and Behavioral Physiology. 51:116-122
The GPCR signal cascade in retinal photoreceptor cells – rods and cones – supports powerful signal amplification and allows rods to respond reliably to single light quanta. Rods remain functional at light fluxes down to 105 quanta/sec, which is s
Publikováno v:
Neuroscience and Behavioral Physiology. 51:108-115
Retinal photoreceptors – cones and rods – are able to undergo light adaptation over a wide range of illumination levels due to a complex of regulatory mechanisms. Among these, the best studied are calcium feedback circuits, which can explain abou
Publikováno v:
Neuroscience and Behavioral Physiology. 50:358-366
No approaches completely restoring lost vision after completion of the active phase of degeneration have as yet been developed for inherited degenerative diseases of the retina. Optogenetic prosthetization of the retina is a potential therapeutic met
Publikováno v:
Biology Bulletin Reviews. 10:1-10
The existence of a magnetic compass system allowing animals to maintain the direction of their migratory journeys was first shown in birds about fifty years ago. Over the past half century, a large amount of indirect, mainly behavioral, data on the f
Publikováno v:
Journal of General Physiology. 151:887-897
Rod photoreceptors of the vertebrate retina produce, in darkness, spontaneous discrete current waves virtually identical to responses to single photons. The waves comprise an irreducible source of noise (discrete dark noise) that may limit the thresh
Autor:
M. L. Firsov
Publikováno v:
Neuroscience and Behavioral Physiology. 49:192-198
Pigmented tapetoretinal degeneration (retinitis pigmentosa, RP) is one of the most severe and widespread forms of inherited retinal degeneration. The mechanisms of occurrence of RP are significantly heterogeneous and combine a whole group of diseases
Autor:
R. V. Cherbunin, Nikita Chernetsov, A. Yu. Rotov, M. L. Firsov, K. V. Kavokin, L. A. Astakhova
Publikováno v:
Journal of Evolutionary Biochemistry and Physiology. 54:498-501
Autor:
A. Yu. Rotov, Vitali M. Boitsov, Mikhail N. Ryazantsev, L. A. Astakhova, M. L. Firsov, V. S. Sitnikova, M V Dubina, A A Evdokimov
Publikováno v:
Acta Naturae. 10:75-84
Application of molecular photochromic ion channel blockers to recover the visual function of a degenerated retina is one of the promising trends in photopharmacology. To this day, several photochromic azobenzene-based compounds have been proposed and